A5087017923- Nuclear Structure and Function
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- interferon and immune responses
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Retinoids in leukemia and cellular processes
- RNA Research and Splicing
- T-cell and B-cell Immunology
- RNA modifications and cancer
- DNA Repair Mechanisms
- Immune Response and Inflammation
Inserm
2020-2024
Institut Curie
2019-2024
Université Paris Sciences et Lettres
2020-2024
Immunité et Cancer
2019-2024
Centre National de la Recherche Scientifique
2019
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These can adapt to such deformation events using dedicated shape-sensing pathways. However, how sensing affects immune function is mostly unknown. Here, we identify a mechanism increases expression chemokine receptor CCR7 and guides dendritic migration from peripheral tissues lymph nodes at steady state. This relies on lipid...
Cellular innate immune sensors of DNA are essential for host defense against invading pathogens. However, the presence self-DNA inside cells poses a risk triggering unchecked responses. The mechanisms limiting induction inflammation by poorly understood. BLM RecQ–like helicase is genome integrity and deficient in Bloom syndrome (BS), rare genetic disease characterized instability, accumulation micronuclei, susceptibility to cancer, immunodeficiency. Here, we show that BLM-deficient...
Abstract While mutations leading to a fragile envelope of the cell nucleus are well known cause diseases such as muscular dystrophies or accelerated aging, pathophysiological consequences recently discovered mechanically induced nuclear ruptures in cells harboring no mutation less known. Here we show that repeated loss integrity nuclei experiencing mechanical constraints promotes senescence nontransformed cells, and induces an invasive phenotype including increased collagen degradation human...
Abstract Motile cells such as immune and cancer experience large deformation events that result from the physical constraints they encounter while migrating within tissues or circulating between organs. It has become increasingly clear these can survive adapt to changes in cell shape using dedicated sensing pathways. However, how impacts their function fate remains largely unknown. Here we identify a mechanism couples motility expression of CCR7, chemokine receptor guides lymph nodes. We...
Dendritic cells (DCs) patrol tissues and migrate to lymph nodes for presentation of collected antigens T cells. This process is needed initiate immune responses against infectious agents as well maintain tolerance tissue self-antigens at steady state. In both cases, DC migration requires the upregulation chemokine receptor CCR7. It well-known that upon infection, CCR7 expression induced by microbial inflammatory components released within environment. However, environmental signals trigger...