A5042814511- Nuclear Structure and Function
- RNA Research and Splicing
- RNA regulation and disease
- HIV Research and Treatment
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Immune cells in cancer
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Animal Disease Management and Epidemiology
- Pulmonary Hypertension Research and Treatments
- HIV/AIDS drug development and treatment
- interferon and immune responses
- ATP Synthase and ATPases Research
- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Tissue Engineering and Regenerative Medicine
Université Paris Cité
2023
Institut Pasteur
2023
Université Paris Sciences et Lettres
2018-2023
Inserm
2016-2023
Institut Curie
2016-2023
Centre National de la Recherche Scientifique
2023
Immunité et Cancer
2018
New York Medical College
2001
The nucleus makes the rules Single cells continuously experience and react to mechanical challenges in three-dimensional tissues. Spatial constraints dense tissues, physical activity, injury all impose changes cell shape. How can measure shape deformations ensure correct tissue development homeostasis remains largely unknown (see Perspective by Shen Niethammer). Working independently, Venturini et al. Lomakin now show that act as an intracellular ruler cellular variations. nuclear envelope...
Abstract The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. Here, we found that measure degree of spatial confinement using largest and stiffest organelle, nucleus. Cell below resting nucleus size deforms nucleus, which expands stretches its envelope. This activates signaling actomyosin cortex via nuclear envelope stretch-sensitive proteins, upregulating cell contractility. We...
The human immunodeficiency virus (HIV) enters the nucleus to establish infection, but role of nuclear envelope proteins in this process is incompletely understood. Inner transmembrane SUN1 and SUN2 connect lamins cytoskeleton participate DNA damage response (DDR). Increased levels or potently restrict HIV infection through an unresolved mechanism. Here, we find that antiviral activities are distinct. HIV-1 HIV-2 preferentially inhibited by SUN2, respectively. We identify inducers stimulate...
Investigations of cellular responses to viral infection are commonly performed on mixed populations infected and uninfected cells or using single-cell RNA sequencing, leading inaccurate low-resolution gene expression interpretations. Here, we deep polyA+ transcriptome analyses novel profiling severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung epithelial cells, sorted based the spike (S) protein. Infection caused a massive reduction in mRNAs long non-coding RNAs (lncRNAs),...
Summary Aging is characterized by gradual immune dysfunction and increased risk for many diseases, including respiratory infections. Genomic instability thought to play a central role in the aging process but mechanisms that damage nuclear DNA are insufficiently defined. Cells migrate or reside within confined environments experience forces applied their nucleus, leading transient envelope (NE) ruptures. NE ruptures associated with damage, Lamin A/C required limit these events. Here, we show...
Abstract The Human Immunodeficiency Virus (HIV) enters the nucleus to establish infection. HIV interacts with nuclear pore components cross envelope. In contrast, role of other proteins envelope in infection is not yet understood. inner transmembrane SUN1 and SUN2 connect lamins interior cytoskeleton cytoplasm. Increased levels or potently restrict through an unresolved mechanism. Here, we find that exhibit a differential viral strain-specific antiviral activity HIV-1 HIV-2. macrophages HeLa...
Aging is characterized by gradual immune dysfunction and increased risk for many diseases, including respiratory infections. Genomic instability thought to play a central role in the aging process but mechanisms that damage nuclear DNA are insufficiently defined. Cells migrate or reside within confined environments experience forces applied their nucleus, leading transient envelope (NE) ruptures. NE ruptures associated with damage, Lamin A/C required limit these events. Here, we show...