A5021804685- RNA modifications and cancer
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Nuclear Structure and Function
- Tissue Engineering and Regenerative Medicine
- Animal Virus Infections Studies
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
- DNA Repair Mechanisms
- RNA Research and Splicing
- interferon and immune responses
Université Paris Sciences et Lettres
2021-2023
Inserm
2021-2023
Institut Curie
2021-2023
Immunité et Cancer
2021
Institut Gustave Roussy
2021
Centre National de la Recherche Scientifique
2021
In innate immune cells, intracellular sensors such as cGAS-STING stimulate type I/III interferon (IFN) expression, which promotes antiviral defense and activation. However, how IFN-I/III expression is controlled in adaptive cells poorly understood. Here, we identify a transcriptional rheostat orchestrated by RELA that confers human T with innate-like abilities to produce IFN-I/III. Despite intact signaling, responses are stunted CD4+ compared dendritic or macrophages. We find lysine residues...
Infected and noninfected bystander dendritic cells have distinct roles in the response to vaccine vector MVA.
Human endogenous retroviruses represent approximately 8% of our genome. Most these sequences are defective except for a few genes such as the ancestral retroviral HEMO envelope gene (Human Endogenous MER34 ORF), recently characterized by group. In this study, we transcriptional activation in primary tumors from The Cancer Genome Atlas (TCGA) and metastatic Gustave Roussy cohort. Pan-cancer detection protein series patient samples validated results. Differential expression analysis various...
Summary Aging is characterized by gradual immune dysfunction and increased risk for many diseases, including respiratory infections. Genomic instability thought to play a central role in the aging process but mechanisms that damage nuclear DNA are insufficiently defined. Cells migrate or reside within confined environments experience forces applied their nucleus, leading transient envelope (NE) ruptures. NE ruptures associated with damage, Lamin A/C required limit these events. Here, we show...
Aging is characterized by gradual immune dysfunction and increased risk for many diseases, including respiratory infections. Genomic instability thought to play a central role in the aging process but mechanisms that damage nuclear DNA are insufficiently defined. Cells migrate or reside within confined environments experience forces applied their nucleus, leading transient envelope (NE) ruptures. NE ruptures associated with damage, Lamin A/C required limit these events. Here, we show...