A5081803869- Chromatin Remodeling and Cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- Nicotinic Acetylcholine Receptors Study
- Pulmonary Hypertension Research and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Chronic Disease Management Strategies
- Head and Neck Surgical Oncology
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Healthcare Systems and Reforms
- Research on Leishmaniasis Studies
- Ovarian cancer diagnosis and treatment
- CO2 Sequestration and Geologic Interactions
- Parasitic infections in humans and animals
- Vascular Anomalies and Treatments
Hubei University of Chinese Medicine
2025
Institut Curie
2012-2024
Shandong First Medical University
2013-2024
Inserm
2002-2023
Université Paris Sciences et Lettres
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2021
Peking Union Medical College Hospital
2021
Fu Wai Hospital
2018-2021
Marie Curie
2018
Sorbonne Université
2018
The alpha6 subunit of the nicotinic acetylcholine receptor (nAChR) is expressed at very high levels in dopaminergic (DA) neurons. However, because lack pharmacological tools selective for alpha6-containing nAChRs, role this etiology nicotine addiction remains unknown. To provide new to investigate issue, we generated an nAChR knock-out mouse. Homozygous null mutants (alpha6-/-) did not exhibit any gross neurological or behavioral deficits. A careful anatomic and molecular examination...
Abstract Rhabdoid tumours (RTs) are highly aggressive of infancy, frequently localized in the central nervous system (CNS) where they termed atypical teratoid/rhabdoid (AT/RTs) and characterized by bi-allelic inactivation SMARCB1 tumour suppressor gene. In this study, temporal control tamoxifen injection Smarcb1 flox/flox ;Rosa26-Cre ERT2 mice, we explore phenotypes associated with at different developmental stages. Injection before E6, birth or 2 months age recapitulates previously...
// Tsion Zewdu Minas 1,* , Didier Surdez 2,3,* Tahereh Javaheri 4,* Miwa Tanaka 5,* Michelle Howarth 6,* Hong-Jun Kang 7,* Jenny Han 1 Zhi-Yan 2,3 Barbara Sax 4 E. Kream 8 Sung-Hyeok Hong Haydar Çelik Franck Tirode Jan Tuckermann 9 Jeffrey A. Toretsky Lukas Kenner 4,10,15 Heinrich Kovar 12,13 Sean Lee 7 Alejandro Sweet-Cordero 6 Takuro Nakamura 5 Richard Moriggl 4,11,16 Olivier Delattre 2,3,14 and Aykut Üren Department of Oncology, Georgetown University Medical Center,...
Abstract We present here a systematic mapping of nAChR subunit mRNAs in Macaca mulatta brain. A fragment, from the transmembrane segments MIII to MIV neuronal subunits was cloned, and shown exhibit high identity (around 95%) corresponding human subunits. Then, specific oligodeoxynucleotides were synthesized for situ hybridization experiments. Both α4 β2 mRNA signals widely distributed brain, being stronger thalamus dopaminergic cells mesencephalon. Most brain nuclei displayed both with...
Abstract We determined the localization of [ 3 H]nicotine, H]cytisine, H]epibatidine, and 125 I]α‐bungarotoxin binding sites in brain rhesus monkey by means receptor autoradiography. The labelings H]epibatidine were highly concordant, except for epibatidine. Layer IV some cortical areas, most thalamic nuclei, presubiculum displayed high levels labeling three ligands. Moderate detected subiculum, septum, mesencephalon. Low present layers I–II VI cortex, cornu Ammonis, dentate gyrus, amygdala....
Abstract Ewing sarcoma is a rare but aggressive disease most common in young adults. This cancer driven by unique chimeric fusion oncogene targeted strategies have been elusive. Here we report the identification of protein kinase PKC-ß (PRKCB) as disease-specific druggable target for treatment sarcoma. We found that transcriptional activation PRKCB was directly regulated EWSR1-FLI1 drives this cancer. phosphorylated histone H3T6 to permit global maintenance H3K4 trimethylation at variety...
BACKGROUND: To describe therapeutic approaches in children with atypical Teratoid Rhabdoid Tumours (ATRT) France.METHODS: Observational study including all less than 18 years old diagnosed ATRT France between 2009 and 2011.RESULTS: Forty seven were included this retrospective study.Six patients received no curative treatment while forty-one had a project.Median age was 1.5 (range 0-16).The disease disseminated 10 patients.Surgical resection complete 21 cases.Chemotherapy administered 41...
Nicotine exposure diminishes the protective breathing and arousal responses to stress (hypoxia). By exacerbating sleep-disordered breathing, this disturbance could underpin well established association between smoking increased risk of sudden infant death syndrome. We show here that during sleep are partially regulated by particular nicotinic acetylcholine receptors (nAChRs). compared sleeping wild-type mutant mice lacking β2 subunit nAChR episodic hypoxia. Arousal from was diminished,...
Rhabdoid tumors (RTs) are aggressive of early childhood characterized by SMARCB1 inactivation. Their poor prognosis highlights an urgent need to develop new therapies. Here, we performed a high-throughput screening approved drugs and identified broad inhibitors tyrosine kinase receptors (RTKs), including pazopanib, the potassium channel inhibitor clofilium tosylate (CfT), as SMARCB1-dependent candidates. Pazopanib targets were PDGFRα/β FGFR2, which most highly expressed RTKs in set primary...
The effect of lifestyle factors on cognitive function related to four major noncommunicable diseases (NCDs) including diabetes, cardiovascular disease, cancer, and chronic respiratory diseases, the relationship between these NCDs have not been fully studied. We aimed investigate longitudinal associations in middle-aged older people, combined effects factors.
Patients with chronic kidney disease (CKD) often encounter cardiovascular complications, most commonly coronary heart disease. Although artery bypass grafting is an effective treatment for this condition, many patients experience cognitive dysfunction after cardiac surgery. The complex interactions among functional status, general anesthesia, cardiopulmonary bypass, and surgical trauma in CKD elevate the risk of neurological issues increase mortality rates Consequently, both quality life...
Predicting the prognosis of patients with acute myocardial infarction (AMI) combined diabetes mellitus (DM) is crucial due to high in-hospital mortality rates. This study aims develop and validate a risk prediction model for these by interpretable machine learning (ML) methods. Data were sourced from Medical Information Mart Intensive Care IV (MIMIC-IV, version 2.2). Predictors selected Least absolute shrinkage selection operator (LASSO) regression checked multicollinearity Spearman's...
Background: The overuse of antibiotics is a serious public health problem in China, causing high rate antimicrobial resistance. This study identified the trends antibiotic consumption China to provide evidence for further intervention. Method: six-year surveillance data on sales from 2012 2017, which served as proxy consumption, were collected 39 care facilities Shandong province, including three tertiary hospitals, six secondary and 30 primary centers. Based Anatomical Therapeutic Chemical...
Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas benign, 10% classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation the ( NF2 ) tumor suppressor is associated with meningioma formation 60% sporadic meningiomas. Deletion p16 INK4a / p14 ARF locus both benign malignant meningiomas, while...
Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging human ATRT at diagnosis precise anatomic origin brain in Rosa26-CreERT2::Smarcb1flox/flox model. This cross-species analysis points to an extra-cerebral for MYC tumors. Additionally, clearly distinguish emerging from cerebellar anterior lobe (CAL) those basal ganglia (BG) intra-ventricular (IV) regions. Molecular characteristics point...
Abstract Objective/Background Proliferation is a widely recognized trigger for pulmonary hypertension (PH), life‐threatening, progressive disorder of blood vessels. This study was aimed to identify some proliferation associated genes/targets better comprehension PH pathogenesis. Methods Human arterial smooth muscle cells (hPASMCs) were cultured in the presence or absence human recombinant platelet derived growth factor (rhPDGF)‐BB. Cells collected metabolomics transcriptomics study. Gene...
Abstract Objective p73 and p63 are two structural functional homologs of p53, their biological functions in cancer progression have attracted attention due to the presence variants generated by genetic polymorphisms. Recently, three single nucleotide polymorphisms (SNPs) genes been associated with female reproduction. In present study, we aimed evaluate relationship between these SNPs ovarian susceptibility clinical pathology. Methods We genotyped (rs873330 [Genbank, refSNP ID] T > C [T:...
Background: Productivity losses due to diabetes are increasing in China, but research about the impact of on productivity urban and rural areas requires further in-depth study. This article provides first estimate cost attributed individuals 20–69 years old China. Methods: The human capital approach is employed measure absenteeism, presenteeism, labor force dropout, premature deaths 20–69-year-old population males females Based life table modelling, we calculate potential lost working people...
Summary The remaining oil or gas saturation are necessary to determine in CO2 injected floods for evaluate EOR EGR. After injecting flood, the component and density of different from water oil, it results capacities slowing down capturing neutron, C/O value capture gamma ratio increase with increasing saturation. Therefore, can be still monitored using spectroscopy logging after flood. porosity borehole fluid affect logging. Large is beneficial identification. And should corrected when used...
Abstract BACKGROUND The analysis and comparison of global DNA methylation patterns has become a gold standard in modern neuropathology. For human central nervous system (CNS) tumors other cancers, the research community collected thousands profiles, leading to discovery definition numerous molecularly distinct tumor types subtypes. Although reliable preclinical mouse models are essential for understanding development validation therapeutic approaches, such analyses have so far not been...