A5101412825- Immune Cell Function and Interaction
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Health and Medical Education
- T-cell and B-cell Immunology
- Orthopedic Surgery and Rehabilitation
- Psoriasis: Treatment and Pathogenesis
- vaccines and immunoinformatics approaches
- Cytokine Signaling Pathways and Interactions
- Oral microbiology and periodontitis research
- Musculoskeletal pain and rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Endodontics and Root Canal Treatments
- Public Health and Environmental Issues
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Shoulder Injury and Treatment
- IL-33, ST2, and ILC Pathways
- Gastrointestinal disorders and treatments
- Parasites and Host Interactions
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
Universidad Nacional de Córdoba
2018-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2025
Research Centre in Biological Chemistry of Córdoba
2018-2025
Finis Terrae University
2024
Universidad Católica de la Santísima Concepción
2020
Secretaría de Salud de Bogotá
2010
Tissue-repair regulatory T cells (trTregs) comprise a specialized cell subset essential for tissue homeostasis and repair. While well-studied in sterile injury models, their role infection-induced damage antimicrobial immunity is less understood. We investigated trTreg dynamics during acute Trypanosoma cruzi infection, marked by extensive strong CD8+ immunity. Unlike trTregs significantly declined secondary lymphoid organs non-lymphoid target tissues correlating with systemic local damage,...
The IL-17 family contributes to host defense against many intracellular pathogens by mechanisms that are not fully understood. CD8+ T lymphocytes key elements microbes, and their survival ability mount cytotoxic responses orchestrated several cytokines. Here, we demonstrated IL-17RA-signaling cytokines sustain pathogen-specific cell immunity. absence of IL-17RA IL-17A/F during Trypanosoma cruzi infection resulted in increased tissue parasitism reduced frequency parasite-specific cells....
IL-17 immune responses in cancer are controversial, with both tumor-promoting and tumor-repressing effects observed. To clarify the role of signaling progression, we used syngeneic tumor models from different tissue origins. We found that deficiencies host IL-17RA or IL-17A/F expression had varying on
Conventional CD4+ T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to elimination remains poorly understood. Here, we describe a subset of tumor-infiltrating Tconv cells characterized by the expression CD39. In several mouse cancer models, observed that CD39+ accumulated tumors but were absent lymphoid organs. Compared CD39- counterparts, exhibited cytotoxic and exhausted signature at transcriptomic level, confirmed high protein inhibitory receptors...
While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, regulatory response mediated by Treg upon infection Trypanosoma cruzi was still poorly characterized. In order to understand role during this protozoan parasite, we determined in time space magnitude phenotypic, functional transcriptional features cell population infected mice. Contrary accumulation reported most...
An imbalance between suppressor and effector immune responses may preclude cure in chronic parasitic diseases. In the case of Trypanosoma cruzi infection, specialized regulatory Foxp3+ T (Treg) cells suppress protective type-1 responses. Herein, we investigated kinetics underlying mechanisms behind regulation parasite-specific CD8+ cell immunity during acute . infection. Using DEREG mouse model, found that Treg play a role initial stages after restraining magnitude parasite control. Early...
Cancer is one of the leading causes death worldwide. The success rate conventional anticancer therapeutic approaches such as chemotherapy limited by non-specific toxicity and low specificity towards specific tumors, which are highly dependent on mutational burden present each patient. Similarly, targeted therapies have proven to induce resistance in numerous malignancies. Therefore, immunotherapy has emerged a better approach discriminate between "the own" non-own", occurs through two types...
ABSTRACT Tissue-repair regulatory T cells (trTregs) constitute a specialized subset renowned for orchestrating tissue homeostasis and repair. While extensively investigated in sterile injury models, their role infection-induced damage the regulation of protective antimicrobial immunity remains largely unexplored. This investigation examines trTregs dynamics during acute Trypanosoma cruzi infection, unique scenario combining extensive with robust antiparasitic CD8+ immunity. Contrary to...
Abstract The IL-17 family contributes to host defense against many intracellular pathogens by mechanisms not fully understood. CD8+ T lymphocytes are key elements microbes and their survival appropriate response is orchestrated several cytokines. Here, we demonstrated that IL-17RA-signaling cytokines sustain pathogen-specific cell immunity. Absence of IL-17RA IL-17A/F during Trypanosoma cruzi infection resulted in increased tissue parasitism reduced frequency parasite-specific cells....
Abstract Background Conventional CD4 + T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to elimination remains poorly understood. Methods Here we describe a subset of Tconv cells characterized by the expression CD39. The phenotype, effector function and transcriptional profile tumor-infiltrating CD39 from different mouse cancer models breast patients were studied multiparametric flow cytometry RNA sequencing. impact vivo CTLA-4 blockade on population...
ABSTRACT The role of IL-17 mediated immune responses in cancer is conflicting as pre-clinical and clinical results show tumor-promoting wel tumor-repressing functions. Herein, we used syngeneic tumor models from different tissue origins a tool to evaluate the signaling progression, dissecting effects cell growth immunity. We that absence IL-17RA or IL-17A/F expression host has contrasting vivo types. observed lack IL-17A/F-IL-17RA cells changed pattern several mediators within...
ObjetivoPlanear, diseñar y ejecutar la estandarización de las metodologías analíticas cuyo montaje se ha realizado con anterioridad.MétodosUna vez establecido el método ensayo realiza un análisis preliminar reproducibilidad interferencia por matriz, para luego realizar validación calcular los atributos del método.ResultadosEn Laboratorio Salud Pública estandarizaron trece métodos analíticos a cuales les calcularon de: límite detección, cuantificación, exactitud, precisión, sensibilidad rango...