A5013778483- Cervical Cancer and HPV Research
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Hepatitis C virus research
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- interferon and immune responses
- Cancer-related gene regulation
- Genital Health and Disease
- Veterinary medicine and infectious diseases
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Macrophage Migration Inhibitory Factor
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Parvovirus B19 Infection Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Genetic factors in colorectal cancer
Inserm
2021-2024
Institut Curie
2024
Immunité et Cancer
2024
Université Paris Sciences et Lettres
2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2023
Instituto de Biología Molecular y Celular de Rosario
2015-2023
Centre International de Recherche en Infectiologie
2021-2023
Université Claude Bernard Lyon 1
2021-2023
École Normale Supérieure de Lyon
2021-2023
Centre National de la Recherche Scientifique
2021-2023
Abstract Regulatory T cells (Tregs) are plastic playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to microenvironment where they reside; as consequence, their molecular and functional profiles differ among tissues pathologies. In tumors, features acquired by remains poorly characterized. Here, we observe that human tumor-infiltrating selectively overexpress CD74, MHC class II invariant chain. CD74 has been previously described regulator antigen-presenting...
High‐risk human papillomavirus (HPV) infection is the principal risk factor for development of cervical cancer. The HPV E6 oncoprotein has ability to target and interfere with several PSD‐95/DLG/ZO‐1 (PDZ) domain‐containing proteins that are involved in control cell polarity. This function can be significant oncogenic activity because a deficiency polarisation marker tumour progression. establishment polarity epithelial cells depend on correct asymmetrical distribution lipids at borders...
Abstract Background Persistent infection with high-risk Human Papillomavirus (HPVs) is associated the development of cervical cancer. The transforming capacity these viruses relies on cooperative action E6 and E7 viral oncoproteins. Among oncogenic activities E6, interaction interference cell polarity PDZ proteins have been well established. One most characterized targets HPV human Disc large 1 (DLG1), a scaffolding protein involved in control proliferation. Interestingly, squamous...
Human Disc large (DLG1) has been demonstrated to be involved in the control of cell polarity and maintenance tissue architecture, is frequently lost human tumours. However, mechanisms controlling DLG1 expression are poorly understood. To further examine regulation expression, we analysed 5' ends transcripts by rapid amplification cDNA polymerase chain reaction. We identified an alternative splicing event region mRNA that generates with two different untranslated regions (5'-UTRs). show...
Human T cell leukemia virus (HTLV)-1 Tax (Tax) protein is very important in viral replication and transformation. localizes the nucleus cytoplasm association with organelles. Some activities of depend on interactions PDZ (PSD-95/Discs Large/Z0-1) domain–containing proteins such as Discs large 1 (DLG1) which involved polarity proliferation. The DLG1 interaction results a cytoplasmic co-localization pattern resembling vesicular aggregates, nature still unknown. To further explore role HTLV-1...
Rift Valley Fever virus (RVFV) and Toscana (TOSV) are two pathogenic arthropod-borne viruses responsible for zoonotic infections in both humans animals; as such, they represent a growing threat to public veterinary health. Interferon-induced transmembrane (IFITM) proteins broad inhibitors of large panel belonging various families genera. However, little is known on the interplay between RVFV, TOSV, IFITM derived from their naturally infected host species. In this study, we investigated...
Abstract Hepatitis E virus (HEV) is currently considered as a global health concern due to the recognition of its zoonotic transmission humans, mainly from swine, and association with development severe cases hepatitis in human risk populations. The lack updated data on HEV state infection swineherds Argentina, necessity robust technologies for detection complex biological samples, positions an emerging issue public health. Here, we have optimized RT‐qPCR internal control more precise...
Abstract Hepatitis E virus (HEV) is a public health concern due to its zoonotic transmission human, being pigs highly recognized reservoir. We previously demonstrated HEV genotype 3 infections in pig herds from the highest commercial active region Argentina. Here, we present case of acute symptomatic hepatitis an elderly man with occupational exposure who referred regular consumption pork and sausages. infection this patient was by serological methods, as well RNA detection serum stool...
Loss of cell polarity is a fundamental process in transformation. Among proteins, we focused on human disc large (DLG1), which localized mainly at adherens junctions and contributes to the control proliferation. We previously demonstrated that its expression altered HPV-associated cervical neoplastic lesions, but mechanisms beyond this remain unknown. In study, analysed contribution HPV proteins changes DLG1 squamous epithelium. observed tissue intracellular misdistribution when high-risk...
IFITMs are broad viral inhibitors capable of interfering with both early and late phases the replicative cycle many different viruses. By comparing 21 IFITM proteins issued from animal species for their ability to inhibit HIV-1, we have identified several that exhibit either enhanced or impaired antiviral behavior.
The InterFeron-Induced TransMembrane proteins (IFITMs) are members of the dispanin/CD225 family that act as broad viral inhibitors by preventing viral-to-cellular membrane fusion. In this study, we uncover egress from Golgi an important step in biology IFITM3 identifying domain regulates process and similarly controls dispanins IFITM1 PRRT2, protein linked to paroxysmal kinesigenic dyskinesia. case IFITM3, high levels expression wild-type , or mutations domain, lead accumulation drive...
Human discs large (DLG1) has been demonstrated to be involved in cell polarity and maintenance of tissue architecture. However, the mechanisms controlling DLG1 expression are not fully understood. This is relevant as lost during later stages malignant progression. We initiated a series studies analyse regulating expression. have previously reported identification an alternative splicing event 5' untranslated region (5'-UTR) mRNA that generates transcripts with two different 5'-UTR (short...
Hepatitis E virus (HEV), with the zoonotic transmission, is one of main agents causing acute hepatitis. In individuals chronic liver disease, infection can cause on disease (ACLD) and lead to fulminant failure. This study aimed analyze impact HEV in a cohort cirrhotic from Rosario, Santa Fe. Ninety-seven (18-82 years old; male=61) cirrhosis different etiology were enrolled; among them, 57 followed up over two years. Blood samples obtained every six months at time decompensation cirrhosis....
Although HEV infection is asymptomatic or self-limiting in most individuals, immunocompromised patients, such as those infected with HIV, viral replication can persist for more than three months leading to chronic progression cirrhosis. Argentina considered a country low endemicity HEV; however, seroprevalence data HIV-infected populations are scarce and, date, there very few reports that provide accurate information on the impact of these immunosuppressed patients our region. This study...
IFITMs are a family of highly related interferon-induced transmembrane proteins that interfere with the processes fusion between viral and cellular membranes thus endowed broad antiviral properties. A number studies have shown how potency is dependent on their steady-state levels, intracellular distribution complex pattern post-translational modifications, parameters overall tributary partners. In an effort to identify additional protein partners involved in biology IFITMs, we devised...