A5076593720- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Inflammatory mediators and NSAID effects
- Liver Diseases and Immunity
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Bariatric Surgery and Outcomes
- Diverse Scientific Research Studies
- Viral gastroenteritis research and epidemiology
- Sepsis Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Antibiotic Use and Resistance
- Systemic Lupus Erythematosus Research
- Nosocomial Infections in ICU
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetes and associated disorders
- Veterinary medicine and infectious diseases
National University of Rosario
2015-2023
Hospital Provincial de Rosario
2012-2022
Education and Research Network
2017
Asociación por los Derechos Civiles
2014
Hospital Universitario Austral
2010-2014
Abstract Background & Aims Cyproterone acetate ( CPA ), an anti‐androgenic drug for prostate cancer, has been associated with drug‐induced liver injury DILI ). We aim to expand the knowledge on spectrum of phenotypes and outcomes ‐induced . Methods Twenty‐two males (70 ± 8 years; range 54–83) developing damage as a result therapy (dose: 150 50 mg/day; 50–200) were included. Severity index causality by RUCAM assessed. Results From 1993 2013, 22 patients retrieved. Latency was 163 97 days....
Nitrofurantoin is a synthetic antibiotic that recommended as first-choice treatment for uncomplicated urinary tract infections. The prescription of this drug has increased dramatically, especially in Latin American countries. We described the demographics, clinical characteristics, biochemical features, and outcome nitrofurantoin-induced liver injury. analyzed 23 cases from DILI Network (LATINDILI) Spanish Registry. Causality was assessed with RUCAM RECAM scale. Of included our series, 96%...
Registration studies show entecavir (ETV) to be effective and safe in NUC-naïve patients with chronic hepatitis B, but relapse rates after treatment discontinuation have not been well established. Relapse predictors of were evaluated naïve HBeAg-positive HBeAg-negative treated ETV. Treatment duration was defined according international guidelines. Virological as reappearance serum B virus (HBV) DNA >2000 IU/mL treatment. A hundred sixty-nine consecutive for a median 181 weeks. 61% HBeAg...
We report the first real‐world prospective multicenter cohort study that evaluated effectiveness and safety of original or generic sofosbuvir‐based regimens in patients with chronic hepatitis C Latin America. The main endpoints were assessment sustained virological response serious adverse events rates. A total 321 treated following included: sofosbuvir plus daclatasvir for 12 ( n = 34) 24 135) weeks, ribavirin 84) 56) 8) 2) weeks. Patients received either (Sovaldi ® , Gilead Sciences,...
Introduction: Registration studies showed entecavir (ETV) to be effective and safe in NUC-naïve patients with chronic hepatitis B virus (HBV), but its effectiveness routine clinical practice is unknown. Materials methods: Sixty-nine HBeAg positive negative NUC naïve HBV were treated ETV for 110 weeks. 63% positive, 16% cirrhotics, mean HBV-DNA was 7.09 log IU/ml ALT 157 IU/ml. Results: Sixty-one (88%) achieved undetectable DNA, 46%, 77% 100% virological response rates at week 24, 48 96 of...
BACKGROUND & AIMS. Studies about the natural history of hepatitis C virus (HCV) infection report variable progression to cirrhosis depending on study design. Retrospective cross-sectional liver clinic studies overestimate rate fibrosis due inclusion patients with more severe disease leaving mild and asymptomatic underrepresented. We evaluated in a group "healthy" subjects, attending voluntary campaign for detection HCV infection.A was launched subjects transfused before 1993. Of 1699...
Background. Efficacy and safety of Pegylated Interferon alfa (PegIFN)-Ribavirin (RBV) for the treatment chronic hepatitis C (CHC) in routine clinical practice seems to be comparable with results randomizedcontrolled trials. Aims. To evaluate efficacy, tolerability CHC PegIFN + RBV "real world" patients Argentina analyze factors associated SVR. Methods. Medical records treated according current guidelines from 2001 2008 were reviewed. Results. 235 included 80.8% completed treatment....
Information about the use of ombitasvir/paritaprevir/ritonavir/dasabuvir ± ribavirin (OBV/PTV/r/DSV RBV) in real-clinical practice Latin America is scarce. We aimed to confirm safety and effectiveness OBV/PTV/r/DSV RBV therapy real-world setting. analyzed a cohort patients with genotype 1 infection treated RBV. Data on demographics, clinical features, safety, virological response were retrospectively collected from 21 centers America. A total 96 received OBV/PTV/r/DSV, associated 68% cases....
Nimesulide is the unique molecule of sulphonanilides class non-steroidal antiinflammatory drugs [NSAIDs]: has analgesic, anti-pyretic, potent anti-inflammatory activities and very good gastro-intestinal [GI] tolerability. Therapeutic action multifactorial, including cyclooxigenase-2 (COX-2) inhibition, scavenging free radicals inhibition various pathways inflammation. oxidatively metabolised via liver cytochromes P450. Several unproven hepatotoxicy-predisposing-factors thought to be present...
Entecavir (ETV) is effective and safe in patients with chronic hepatitis B the short term, but its long term efficacy safety has not been established.We evaluated HBV DNA clearance, HBeAg/antiHBe HBsAg/antiHBs seroconversion rates HBeAg-positive negative NUC naïve treated ETV for more than 6 months, predictors of response.A hundred sixty nine consecutive were a median 181 weeks. 61% HBeAg positive, 23% cirrhotics, mean HBV-DNA levels 6,88 ± 1,74 log10 IU/mL. Overall, 156 (92%) became...
Abstract Hepatitis E virus (HEV) is a public health concern due to its zoonotic transmission human, being pigs highly recognized reservoir. We previously demonstrated HEV genotype 3 infections in pig herds from the highest commercial active region Argentina. Here, we present case of acute symptomatic hepatitis an elderly man with occupational exposure who referred regular consumption pork and sausages. infection this patient was by serological methods, as well RNA detection serum stool...
The Latin American DILI (LATINDILI) Network is an international registry of prospectively identified drug-induced liver injury (DILI) cases to enhance case characterization. We aimed analyze features and outcomes in America. Information included the LATINDILI database between 2011 July 2022 was collected analyzed. Of 468 patients included, 13 had positive rechallenge 5 recurrent (different drugs). Mean age 49 years (range 14- 89), 62% women. most common type hepatocellular (62%). Overall,...
The introduction of direct-acting antiviral (DAA) agents promises to change dramatically the management hepatitis C in kidney transplant recipients, a patient group where treatment is historically challenging. purpose current study was assess (in 'real-life' setting) safety and efficacy all-oral, interferon-free, recipients with HCV. We performed single-arm, multi-center cohort (n = 95) who underwent therapy DAAs. primary end-point sustained virologic response (SVR) (serum HCV RNA < 15...
Liver disease accounts for approximately 2 million deaths per year worldwide and is often not detected early in the general population. This study aimed to presence of liver population Rosario, Argentina (1.5 inhabitants). 600 individuals over 18 years were studied who spontaneously attended our Hospital as part a campaign called "Take care your liver," carried out from October 4 14, 2019. Anthropometric data, history previous diseases socioeconomic status documented. tests, serology...