A5020425687- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- COVID-19 Clinical Research Studies
- Genital Health and Disease
- Mosquito-borne diseases and control
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Cervical Cancer and HPV Research
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Genomics and Rare Diseases
- Cancer-related gene regulation
- Insect symbiosis and bacterial influences
University of Padua
2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2018-2022
National University of Rosario
2018-2022
Instituto de Biología Molecular y Celular de Rosario
2018-2022
The high mutation rate of SARS-CoV-2 leads to the emergence multiple variants, some which are resistant vaccines and drugs targeting viral elements. Targeting host dependency factors, e.g. cellular proteins required for replication, would help prevent development resistance. However, it remains unclear whether different variants induce conserved responses exploit same core factors. To this end, we compared three concern found that transcriptional response was conserved, differing only in...
Abstract Background Persistent infection with high-risk Human Papillomavirus (HPVs) is associated the development of cervical cancer. The transforming capacity these viruses relies on cooperative action E6 and E7 viral oncoproteins. Among oncogenic activities E6, interaction interference cell polarity PDZ proteins have been well established. One most characterized targets HPV human Disc large 1 (DLG1), a scaffolding protein involved in control proliferation. Interestingly, squamous...
Abstract Background Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions thus interfere with a variety relevant cellular targets. Among them, expression some PDZ-containing polarity proteins, as DLG1 hScrib, is altered during HPV life cycle consequent malignant transformation. Together well-established interference PDZ we have recently shown that oncoprotein also...