A5019914970- Veterinary Oncology Research
- Microbial Inactivation Methods
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Microbial infections and disease research
- Tumors and Oncological Cases
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- Oral and Maxillofacial Pathology
- Infectious Diseases and Mycology
- Cancer and Skin Lesions
- Extracellular vesicles in disease
- Magnetic and Electromagnetic Effects
- Long-Term Effects of COVID-19
- Oral and gingival health research
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Advanced Biosensing Techniques and Applications
- Hedgehog Signaling Pathway Studies
- Circular RNAs in diseases
- Veterinary Medicine and Surgery
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
University of Padua
2020-2025
University of Pisa
2019
Abstract Background Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence this toxin gene in CRC patients with respect healthy subjects, and numerous tumor-promoting effects that have been ascribed vitro. Despite evidence, a definitive causal link between CNF1 was missing. Here we investigated whether plays an...
The high mutation rate of SARS-CoV-2 leads to the emergence multiple variants, some which are resistant vaccines and drugs targeting viral elements. Targeting host dependency factors, e.g. cellular proteins required for replication, would help prevent development resistance. However, it remains unclear whether different variants induce conserved responses exploit same core factors. To this end, we compared three concern found that transcriptional response was conserved, differing only in...
Abstract Non‐tonsillar squamous cell carcinoma (ntSCC) is a common and locally aggressive oral tumour in dogs. The treatments of choice are currently surgery radiotherapy. Electrochemotherapy (ECT) local ablative anti‐tumour technique using electric pulses to enhance the intracellular diffusion cytotoxic drugs. aim was retrospectively evaluate outcome patients with ntSCC treated ECT. Twelve dogs were enrolled. ECT combined IV bleomycin (15 000 UI/m 2 ) alone 11 cases post‐surgery 1....
Feline squamous cell carcinoma (SCC) is currently treated with surgery, radiation therapy and electrochemotherapy (ECT). Both the efficacy and/or safety of ECT were evaluated as a sole bleomycin to treat feline nasal planum SCC (npSCC). Sixty-one cats enrolled. Local treatment response was complete remission (CR), partial (PR) or stable disease (SD). Recurrence rate (RR), disease-free interval (DFI) progression free survival (PFS) calculated. A six-point scale used for toxicity. The median...
Tumor cells can induce important cellular and molecular modifications in the tissue or host where they grow. The idea that tumor interact with each other has led to concept of a microenvironment, composed immune cells, stromal blood vessels, extracellular matrix, representing unique environment participating and, some cases, promoting cancer progression. study particularly focusing on role tumor-infiltrating lymphocytes (TILs), is highly relevant oncology due prognostic therapeutic...
Benign mammary lesions are infrequent in cats. Among these, the most common is feline fibroadenomatous change, a hyperplastic/dysplastic change associated with hormonal imbalances. Although never thoroughly described scientific literature, fibroadenomas, which share some morphological features have been variably included classification systems. The aim of this study was to characterise fibroadenomas from histological and immunophenotypical point view order allow standardisation...
Introduction Canine lymphoma (cL) is one of the most frequent cancers in dogs. The T-cell (TcL) not common phenotype but presents an aggressive behavior. MicroRNAs (miRNAs), are small, single-stranded, non-coding RNA molecules which can circulate freely blood or be associated with extracellular vesicles (EVs). dysregulation certain miRNAs has been identified numerous types human and they have largely investigated as possible tumors biomarkers medicine, while research veterinary oncology...
Case summary A 7-year old male neutered domestic shorthair cat was presented with a 2 month history of slow-growing mass on the right zygomatic area. CT scan revealed soft tissue in region no alterations underlying bone and features local invasiveness. Cytology suggestive mesenchymal tumour histopathology from an incisional biopsy consistent sarcoma (STS). The treated neoadjuvant intravenous doxorubicin chemotherapy at dose 25 mg/m , every two weeks. patient experienced partial response...
Abstract Formaldehyde fixation is worldwide the most used system for histopathological examination. However, its toxicity well known, and preservation of proteins nucleic acids not optimal. Alternative fixatives warranting similar morphological quality tissues costs, but lacking allowing better would therefore increase both safety operators molecular analysis in pathology. This multi-institutional study aimed to compare morphological, histochemical, immunohistochemical (IHC), analyses...
Abstract Background Primary laryngeal neoplasms are rare in cats, with lymphoma and squamous cell carcinoma being the most commonly diagnosed tumour types. These tumours usually highly aggressive, difficult to treat, have a poor prognosis. Here an undifferentiated hyaline bodies cat is reported. Case presentation A 13-year-old was presented for progressive respiratory signs. Diagnostic procedures revealed partially obstructive mass. Cytology compatible poorly differentiated malignant tumour,...
Abstract The high mutation rate of SARS-CoV-2 leads to emergence several variants, some which are resistant vaccines and drugs targeting viral elements. Targeting host dependency factors – cell proteins required for replication - would help avoid resistance. However, whether different variants induce conserved responses exploit the same core is still unclear. We compared three concern observed that transcriptional response was conserved, differing only in kinetics magnitude. By CRISPR...
Abstract A 6‐year‐old, male neutered, domestic shorthair cat was presented for further investigation of a right‐sided kidney mass. contrast‐enhanced computed tomography scan head, thorax and abdomen showed renal mass, with infiltration the surrounding tissue, but no evidence distant metastasis. Cytology consistent poorly differentiated neoplasia, nephrectomy performed. Following surgery, underwent multiple blood transfusions due to severe anaemia developed tricavitary effusion compatible...