A5024522196- Veterinary Oncology Research
- Veterinary Medicine and Surgery
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Virus-based gene therapy research
- Tumors and Oncological Cases
- Infectious Diseases and Mycology
- Pancreatitis Pathology and Treatment
- Oral and Maxillofacial Pathology
- Reproductive Biology and Fertility
- Wnt/β-catenin signaling in development and cancer
- Drug Transport and Resistance Mechanisms
- Extracellular vesicles in disease
- Reproductive Physiology in Livestock
- Soft tissue tumor case studies
- Animal Virus Infections Studies
- Trace Elements in Health
- Hedgehog Signaling Pathway Studies
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Prion Diseases and Protein Misfolding
- Hippo pathway signaling and YAP/TAZ
- Infectious Disease Case Reports and Treatments
- Wound Healing and Treatments
- Research on Leishmaniasis Studies
University of Padua
2015-2024
Universidad de La Sabana
2024
Ospedale Sant'Anna
2022
University of Zurich
2013
Toronto General Hospital
1992
Skin wound healing includes a system of biological processes, collectively restoring the integrity skin after injury. Healing by second intention refers to repair large and deep wounds where tissue edges cannot be approximated substantial scarring is often observed. The objective this study was evaluate effects mesenchymal stem cells (MSCs) in using surgical model sheep. MSCs are known contribute inflammatory, proliferative, remodeling phases regeneration process rodent models, but data...
Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some yet unrevealed mechanisms of active release. This study aimed to preliminarily analyze dogs with canine mammary tumors (CMTs). Forty-four neoplastic, 17 non-neoplastic disease-bearing, 15 healthy were recruited. Necrosis apoptosis also assessed...
Pancreatic amyloidosis and loss of α β cells have been shown to occur in cats with diabetes mellitus, although the number studies currently available is very limited. Furthermore, it not known whether pancreatic islet inflammation a common feature. The aims present study were characterize lesions investigate diabetic islets. Samples pancreas collected postmortem from 37 20 control matched for age, sex, breed, body weight. Histologic sections stained hematoxylin eosin Congo red; double...
Abstract AA amyloidosis is a systemic disease characterized by deposition of misfolded serum amyloid A protein (SAA) into cross-β in multiple organs humans and animals. occurs at high SAA levels during chronic inflammation. Prion-like transmission was reported as possible cause extreme prevalence captive animals, e.g. 70% cheetah 57–73% domestic short hair (DSH) cats kept zoos shelters, respectively. Herein, we present the 3.3 Å cryo-EM structure extracted post-mortem from kidney DSH cat...
Epithelial-to-mesenchymal transition (EMT) is a process by which epithelial cells acquire mesenchymal properties. EMT has been closely associated with cancer cell aggressiveness. The aim of this study was to evaluate the mRNA and protein expression EMT-associated markers in mammary tumors humans (HBC), dogs (CMT), cats (FMT). Real-time qPCR for SNAIL, TWIST, ZEB, immunohistochemistry E-cadherin, vimentin, CD44, estrogen receptor (ER), progesterone (PR), ERBB2, Ki-67, cytokeratin (CK) 8/18,...
The aim of this retrospective study was to describe clinical features, treatment and outcome 21 dogs with metastatic cancer unknown primary (MCUP), a biopsy-proven malignancy being diagnosed at stage, in which the anatomical origin tumour cannot be detected. All underwent total-body computed tomography. Signalment, type duration signs, metastasis site, pathology results, were recorded. Carcinoma most common diagnosis (57.1%), followed by sarcoma, melanoma mast cell tumour. median number...
Canine visceral leishmaniasis frequently causes renal damage that leads to chronic kidney disease. Fifteen dogs seropositive for Leishmania were selected and biopsied before (T0) 60 days later after (T1) treatment with a specific anti- pharmacological agent. Various parameters evaluating the glomerular tubulointerstitial damage. At T0, mesangioproliferative membranoproliferative glomerulonephritis observed in 6 dogs, glomerulosclerosis 5, end-stage 3; tissue from 1 dog was within normal...
Pancreatitis has been described in cats with diabetes mellitus, although the number of studies currently available is very limited. In addition, ketoacidosis hypothesized to be associated pancreatitis diabetic cats. The aims present study were investigate whether have and determine if more frequent ketoacidosis. Samples pancreas collected postmortem from 37 cats, including 15 ketoacidosis, 20 control matched for age, sex, breed, body weight. Sections stained hematoxylin eosin, double-labeled...
Lack of dental eruption may be accompanied by development dentigerous cysts and has also been rarely associated to neoplasia. However, little information is available on prevalence unerupted teeth lesions in dogs cats. The main objective this study was describe the epidemiologic data canine feline patients with teeth, assess tumors. Secondary aims included evaluation possible factors implicated cystic development, description histological features cysts. Medical records, intraoral...
The biological effect of alkaline water consumption is object controversy. present paper presents a 3-year survival study on population 150 mice, and the data were analyzed with accelerated failure time (AFT) model. Starting from second year life, nonparametric plots suggest that mice watered showed better than control mice. Interestingly, statistical analysis revealed provides higher longevity in terms "deceleration aging factor" as it increases functions when compared group; namely,...
Systemic AA-amyloidosis is a protein-misfolding disease characterized by fibril deposition of serum amyloid-A protein (SAA) in several organs humans and many animal species. Fibril deposits originate from abnormally high levels SAA during chronic inflammation. A prevalence has been reported captive cheetahs horizontal transmission proposed. In domestic cats, mainly described predisposed breeds but only rarely short-hair cats. Aims the study were to determine dead shelter Liver, kidney,...
Histology, immunohistochemistry (IHC), and reverse transcription polymerase chain reaction (RT-PCR) have been used to diagnose feline infectious peritonitis (FIP), but no information regarding the comparison of their diagnostic performances on same organ is available. The aims this study were determine concordance among these tests evaluate which combination organs can be in vivo. IHC, nested RT-PCR (RT-nPCR) for coronavirus (FCoV) performed spleen, liver, mesenteric lymph node, kidney,...
The objective of this study was to assess duration efficacy, side effects and return fertility following use the 9.4 mg deslorelin implant (Suprelorin 12; Virbac) in cats, test whether efficacy action are influenced by implantation site (interscapular vs periumbilical).
Concurrent leishmaniasis and neoplasia has been reported in dogs. This study describes the presence of protozoa within cytoplasm neoplastic cells 3 different types tumors. Leishmania amastigotes were detected by light transmission electron microscopy immunohistochemistry a fibrosarcoma, T-cell lymphoma, an adrenocortical adenoma.
The main aim of this retrospective study was to describe clinical and histopathological findings in cats with mucogingival lesions developed at the contact point premolar molar teeth opposite quadrant. Cases were retrieved following manual review medical records, dental records photographic documentation all feline patients visited period between February 2001 August 2011. Cats showing different times calculated as multiple cases. A total 27 (31 cases) 44 (26 proliferations [59%], 11 clefts...
Dermoid sinus, a congenital malformation of neural tube development, has been reported in humans and several animal species including dogs. It is typically found the dorsal midline commonly occurs Rhodesian Ridgeback breed. A case multiple dermoid sinuses fronto-occipital region described. An 11-month-old, intact female Saint Bernard dog was presented with 2 day history discharge from large irregular subcutaneous mass region. The otherwise healthy. had two circular skin lesions...
Extracellular vesicles (EVs) are membrane‐bound produced by cells, known to play a key role in cell‐to‐cell communication. They exert pleiotropic biological functions via the horizontal transfer of bioactive molecules (DNA, RNAs, proteins, and lipids) within tumour microenvironment throughout body. In human cancer, EVs interfere with pathways that lead progression used as novel cancer biomarkers. veterinary medicine, very little is on cancer‐derived EVs. this study, we preliminarily...
A 5-year-old, neutered male domestic shorthair cat was referred for evaluation of suspected hypothyroidism. In the previous 2 months, owner reported mild lethargy, weight gain with decreased appetite, unkempt hair coat, and an episode bilateral external otitis that temporarily improved after a 10-day treatment ear medications containing gentamicin, betamethasone, clotrimazole1; completed 50 days before presentation. The had been slightly overweight several months referring veterinarian...