A5037236636- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Gene expression and cancer classification
- Breast Cancer Treatment Studies
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Vascular Tumors and Angiosarcomas
- Neuroendocrine Tumor Research Advances
- Chromatin Remodeling and Cancer
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Cardiac tumors and thrombi
- Molecular Biology Techniques and Applications
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
Institut Bergonié
2015-2024
Inserm
2012-2022
Institute of Bioinformatics
2022
Bordeaux Population Health
2020
National Taiwan University Hospital
2019
Centre de Recherche des Cordeliers
2019
Institut Curie
2007-2016
NutriNeuro
2016
Cancer Institute (WIA)
2016
Université Paris Sciences et Lettres
2015
Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes1,2. The clinical presentation patients different subtypes is often atypical, and responses to therapies such as immune checkpoint blockade vary widely3,4. To explain this variability, here we study gene expression profiles in 608 tumours across soft-tissue sarcoma. We establish an immune-based classification on the basis composition tumour microenvironment identify five distinct...
Gene expression analysis of target organs might help provide new insights into the pathogenesis autoimmune diseases. We used global gene profiling minor salivary glands to identify patterns in patients with primary Sjögren's syndrome (pSS), a common and prototypic systemic disease. allowed for differentiating most pSS from controls. The 23 genes IFN pathways, including two Toll-like receptors (TLR8 TLR9), was significantly different between Furthermore, increased IFN-inducible genes, BAFF...
Research Article17 June 2010Open Access Oxidative stress promotes myofibroblast differentiation and tumour spreading Aurore Toullec Laboratory of strem cancer, Inserm U830, Institut Curie, 75248 Paris, Cedex, France Search for more papers by this author Damien Gerald These authors contributed equally to study. Gilles Despouy Brigitte Bourachot Melissa Cardon Sylvain Lefort Marion Richardson Département de Transfert, Laboratoire signalisation, Guillem Rigaill Maria-Carla Parrini Inserm,...
Abstract Introduction Typical medullary breast carcinoma (MBC) has recently been recognized to be part of the basal-like spectrum, a feature in agreement with high rate TP53 mutations previously reported MBCs. The present study was therefore designed identify phenotypic and genetic alterations that distinguish MBCs from carcinomas (BLC). Methods Expression levels estrogen receptor (ER), progesterone (PR), ERBB2, TP53, cytokeratins (KRTs) 5/6, 14, 8/18, epidermal growth factor KIT, as well...
Abstract Introduction Identification of new therapeutic agents for breast cancer (BC) requires preclinical models that reproduce the molecular characteristics their respective clinical tumors. In this work, we analyzed genomic and gene expression profiles human BC xenografts corresponding patient Methods Eighteen were obtained by grafting tumor fragments from patients into Swiss nude mice. Molecular characterization tumors was performed DNA copy number analysis using Affymetrix Microarrays....
To gain insight into genomic and transcriptomic subtypes of ductal carcinomas in situ the breast (DCIS).We did a combined phenotypic analysis series 57 DCIS integrated with gene expression profile for 26 cases.Thirty-two exhibited luminal phenotype; 21 were ERBB2 positive, 4 ERBB2/estrogen receptor (ER) negative 1 harboring bona fide basal-like phenotype. Based on CGH analysis, types identified this 1q gain/16q loss combination observed 3 DCIS, mixed amplifier pattern including all ERBB2, 12...
Abstract Rhabdoid tumours (RTs) are highly aggressive of infancy, frequently localized in the central nervous system (CNS) where they termed atypical teratoid/rhabdoid (AT/RTs) and characterized by bi-allelic inactivation SMARCB1 tumour suppressor gene. In this study, temporal control tamoxifen injection Smarcb1 flox/flox ;Rosa26-Cre ERT2 mice, we explore phenotypes associated with at different developmental stages. Injection before E6, birth or 2 months age recapitulates previously...
Patients with advanced soft-tissue sarcomas (STS) have a median overall survival of less than 18 months. Identification molecular abnormalities for which targeted therapies are available or can be developed is critical improving patient outcomes.To characterize targetable genomic alterations (GAs) in patients STS.This cross-sectional study next-generation sequencing results from 584 STS included the AACR GENIE Database.Presence GAs STS.Of analysis, 294 (50.3%) were men and 290 (49.7%) women,...
Abstract The pathological classification of gliomas constitutes a critical step the clinical management patients, yet it is frequently challenging. To assess relationship between genetic abnormalities and clinicopathological characteristics, we have performed analysis series gliomas. A total 112 were analyzed by comparative genomic hybridization on BAC array with 1 megabase resolution. Altered regions identified correlation enabled to retrieve significant associations exclusions. Whole...
Abstract Predicting evolution of small node‐negative breast carcinoma is a real challenge in clinical practice. The aim this study was to search whether qualitative or quantitative DNA changes may help predict metastasis carcinoma. Small invasive ductal carcinomas without axillary lymph node involvement (T1T2N0) from 168 patients with either good (111 no event at 5 years after diagnosis) poor (57 early metastasis) outcome were analyzed comparative genomic hybridization (CGH) array. A CGH...
The extracellular matrix (ECM) plays an instrumental role in determining the spatial orientation of epithelial polarity and formation lumens glandular tissues during morphogenesis. Here, we show that Endoplasmic Reticulum (ER)-resident protein anterior gradient-2 (AGR2), a soluble protein-disulfide isomerase involved ER folding quality control, is secreted interacts with ECM. Extracellular AGR2 (eAGR2) microenvironmental regulator tissue architecture, which preneoplastic phenotype...
Myocardin (MYOCD), a serum response factor (SRF) transcriptional cofactor, is essential for cardiac and smooth muscle development differentiation. We show here by array-based comparative genomic hybridization, fluorescence in situ expression analysis approaches that MYOCD gene highly amplified overexpressed human retroperitoneal leiomyosarcomas (LMS), very aggressive well-differentiated tumor. inactivation shRNA LMS cell line with locus amplification leads to dramatic decrease of...
BackgroundUndifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized subtype. This study aims to assess UPS molecular characteristics identify specific therapeutic targets.MethodsHigh-throughput technologies encompassing immunohistochemistry, RNA-sequencing, whole exome-sequencing, mass spectrometry, as well radiomics were used characterize three independent cohorts of 110, 25 41 selected after histological review performed by an expert pathologist....
Abstract Our objective was to capture subgroups of soft-tissue sarcoma (STS) using handcraft and deep radiomics approaches understand their relationship with histopathology, gene-expression profiles, metastatic relapse-free survival (MFS). We included all consecutive adults newly diagnosed locally advanced STS ( N = 225, 120 men, median age: 62 years) managed at our reference center between 2008 2020, contrast-enhanced baseline MRI. After MRI postprocessing, segmentation, reproducibility...
Abstract Somatically acquired chromosomal imbalances are a key feature of neuroblastoma, heterogeneous pediatric solid tumor. Among these alterations, genomic amplification targeting the MYCN oncogene and observed in about 25–30% cases, strongly correlates with advanced stage poor outcome. In this work, we have used BAC SNP arrays as well gene expression to characterize amplifications neuroblastoma. Eighty‐eight distinct BACs defining high‐level events were identified 65 samples, including...