A5023085286- Chronic Lymphocytic Leukemia Research
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Ovarian cancer diagnosis and treatment
- Ocular Oncology and Treatments
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Genetic Neurodegenerative Diseases
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Porphyrin Metabolism and Disorders
- Prostate Cancer Treatment and Research
- Ion Channels and Receptors
- Plant Genetic and Mutation Studies
Inserm
2010-2024
Université de Tours
2021-2023
Institut Curie
2007-2021
Université Paris Sciences et Lettres
2017-2021
Clinical Investigation Center Plurithematic Tours
2021
La Ligue Contre le Cancer
2020
Institut National du Sport, de l'Expertise et de la Performance
2019
Research Article17 June 2010Open Access Oxidative stress promotes myofibroblast differentiation and tumour spreading Aurore Toullec Laboratory of strem cancer, Inserm U830, Institut Curie, 75248 Paris, Cedex, France Search for more papers by this author Damien Gerald These authors contributed equally to study. Gilles Despouy Brigitte Bourachot Melissa Cardon Sylvain Lefort Marion Richardson Département de Transfert, Laboratoire signalisation, Guillem Rigaill Maria-Carla Parrini Inserm,...
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature leukemia. Recent studies detected genomic aberrations affecting JAK STAT genes in T-PLL. Due to the limited number of primary patient samples available, analyses JAK/STAT pathway have been performed rather small cohorts. Therefore, we conducted—via primary-data based pipeline—a meta-analysis that re-evaluated landscape It included all available data sets with sequence information on or gene loci 275 We eliminated...
Ovarian cancer is a silent disease with poor prognosis that urgently requires new therapeutic strategies. In low-grade ovarian tumours, mutations in the MAP3K BRAF gene constitutively activate downstream kinase MEK. Here we demonstrate an additional MAP3K, MAP3K8 (TPL-2/COT), accumulates high-grade serous carcinomas (HGSCs) and potential prognostic marker for these tumours. By combining analyses on HGSC patient cohorts, cells patient-derived xenografts, controls cell proliferation migration...
Ataxia-telangiectasia (A-T) is a recessive disorder caused by biallelic pathogenic variants of ataxia-telangiectasia mutated (ATM). This disease characterized progressive ataxia, telangiectasia, immune deficiency, predisposition to malignancies, and radiosensitivity. However, hypomorphic may be discovered associated with very atypical phenotypes, raising the importance evaluating their effects. In this study, multiple functional analyses were performed on lymphoblastoid cell lines from 36...
Abstract Genes involved in 3′-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated factor cancer, and mutants corrupt branchpoint leading to usage cryptic sites subsequent aberrant junctions. For a comprehensive determination alterations this pattern, we performed pan-TCGA screening for SF3B1-specific acceptor usage. While patterns were explained by mutations, also detected nine wild-type tumors (including five lung...
The prostate gland is surrounded by periprostatic adipose tissue (PPAT), which believed to play a role in cancer (PCa) progression. Cancer cells can take up lipids from the microenvironment and store them lipid droplets (LDs). Fatty acids released LDs are used PCa as preferential metabolic fuels provide energy promote Recently, fatty have been associated with autophagy, cellular recycling pathway. Lipophagy selective form of autophagy involved LD degradation, progression remains unknown....
// Lucie Hebert 1 , Dorine Bellanger Chloé Guillas Antoine Campagne 2 Florent Dingli 3 Damarys Loew Alice Fievet 1, 4 Virginie Jacquemin Tatiana Popova Didier Jean 5 Fatima Mechta-Grigoriou Raphaël Margueron and Marc-Henri Stern Department of Genetics Biology Cancers, INSERM U830, Institut Curie, PSL Research University, Paris 75248, France Developmental Genetics, CNRS UMR 3215/INSERM U934, Mass Spectrometry Proteomics facility, UMR-1162, 75010, Correspondence to: Stern, email:...
The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting mRNA splicing. Further SF3B1 have been reported cancers but their consequences remain unclear. Here, we screened for vicinity region tumors. We then performed in-silico prediction functional outcome followed in-cellulo modelling different mutants. show that cancer-associated present varying are loosely predicted algorithms. Analysis tertiary structure mutants revealed...
Ataxia-telangiectasia-like disorder (ATLD) is a rare genomic instability syndrome caused by biallelic variants of MRE11 (meiotic recombination 11) characterized progressive cerebellar ataxia and typical karyotype abnormalities. These symptoms are common to those ataxia-telangiectasia, which consistent with the key role in ataxia-telangiectasia mutated (ATM) activation after DNA double-strand breaks. Three unrelated French patients were referred ataxia. Only one had Unreported found these...
White adipose tissue interacts closely with breast cancers through the secretion of soluble factors such as cytokines, growth or fatty acids. However, molecular mechanisms these interactions and their roles in cancer progression remain poorly understood. In this study, we investigated role acids cooperation between adipocytes cells using a co-culture model. We report that increase autophagy acidification lysosomes, leading to cell survival nutrient-deprived conditions migration....
Nijmegen breakage syndrome caused by biallelic pathogenic variants of the DNA-damage response gene NBN, is characterized severe microcephaly, cancer proneness, infertility, and karyotype abnormalities. We previously reported NBN in siblings suffering from fertility defects. Here, we identify a new founder variant (c.442A>G, p.(Thr148Ala)) Lebanese patients associated with isolated infertility. Functional analyses explored preserved or altered functions correlated their remarkably mild...
ABSTRACT Calcium (Ca 2+ ) is an essential and ubiquitous second messenger controlling numerous cellular functions. Ca signaling relied on the finely tuned oscillations of cytosolic concentrations induced by components toolkit (ion channels, pumps ion exchangers). The regulation these define a signature that representative identity phenotype cell. In cancers, molecular actors are aberrantly expressed. We hypothesized cancer cells their identity, tissue origins (TOO) as well isolation site...
Abstract Background Periprostatic adipose tissue (PPAT) is likely to modulate prostate cancer (PCa) progression. We analyzed the variations in effect of PPAT on cells, according its fatty acid (FA) composition and tumor characteristics. Methods The expression markers aggressiveness Ki67 Zeb1, epigenetic marks that could be modified during PCa progression, was by immunohistochemistry a tissue‐micro‐array containing 59 pT3 PCa, including intra‐prostatic areas extra‐prostatic foci contact with...
Abstract Aberrant alternative splicing is emerging as a frequent and important process in cancer. Splice aberrations are mainly associated with missense mutations within genes encoding splice factors involved 3′-splice site recognition. SF3B1, U2AF1, SRSF2 ZRSR2 the most frequently mutated tumors. Interestingly, these mutually exclusive each leads to distinct aberrant pattern. Based on RNA-seq analyses of 74 primary tumors uveal melanoma, we previously defined pattern SF3B1 hotspot...
Aberrant alternative splicing is emerging as a frequent and important process in cancer. Splice aberrations are mainly associated with missense mutations within genes encoding splice factors involved 3′-splice site recognition. SF3B1, U2AF1, SRSF2 ZRSR2 the most frequently mutated tumors. Interestingly, these mutually exclusive each leads to distinct aberrant pattern.Based on RNA-seq analyses of 74 primary tumors uveal melanoma, we previously defined pattern SF3B1 hotspot mutations. In order...