A5002613498- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Electromagnetic Fields and Biological Effects
- Adolescent and Pediatric Healthcare
- Family Support in Illness
- Cancer survivorship and care
- Cancer Risks and Factors
- Noise Effects and Management
- Breast Cancer Treatment Studies
- Air Quality and Health Impacts
- Multiple and Secondary Primary Cancers
- Wireless Body Area Networks
- Clinical practice guidelines implementation
- Colorectal Cancer Screening and Detection
- Chemotherapy-induced cardiotoxicity and mitigation
- BRCA gene mutations in cancer
- Lymphoma Diagnosis and Treatment
- Radiation Dose and Imaging
- Statistical Methods and Bayesian Inference
- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
- Cancer therapeutics and mechanisms
Concept Life Sciences (United Kingdom)
2024
BC Cancer Agency
2012-2023
Northwestern University
2022
University Hospitals Seidman Cancer Center
2022
Case Western Reserve University
2022
University of British Columbia
2009-2019
Canadian Centre for Applied Research in Cancer Control
2006-2018
Ottawa Hospital
2017
Public Health Agency of Canada
2015
Lurie Children's Hospital
2014
Previous studies have suggested an association between exposure to 50–60 Hz magnetic fields (EMF) and childhood leukaemia. We conducted a pooled analysis based on individual records from nine studies, including the most recent ones. Studies with 24/48-hour field measurements or calculated were included. specified which data analyses we planned do how them before commenced work. The use of allowed us same definitions, large numbers subjects enabled more precise estimation risks at high...
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, corticosteroids has been proposed as potential treatment for patients sepsis.To determine whether hydrocortisone every 6 hours increases ventilator- vasopressor-free days compared placebo in sepsis.Multicenter, randomized, double-blind, adaptive-sample-size, placebo-controlled trial conducted adult sepsis-induced respiratory and/or cardiovascular dysfunction. Participants were enrolled...
The very rapid worldwide increase in mobile phone use the last decade has generated considerable interest possible health effects of exposure to radio frequency (RF) fields. A multinational case-control study, INTERPHONE, was set-up investigate whether increases risk cancer and, more specifically, RF fields emitted by phones are carcinogenic. study focused on tumours arising tissues most exposed from phones: glioma, meningioma, acoustic neurinoma and parotid gland tumours. In addition a...
In a case-control study of childhood leukemia in relation to exposure power-frequency electric and magnetic fields (EMF), 399 children resident five Canadian provinces who were diagnosed at ages 0–14 years between 1990 1994 (June 1995 British Columbia Quebec) enrolled, along with controls. Exposure assessment included 48-hour personal EMF measurement, wire coding field measurements for subjects' residences from conception diagnosis/reference date, 24-hour bedroom measurement. Personal not...
A large number of women survive a diagnosis breast cancer. Knowledge their risk developing new primary cancer is important not only in relation to potential side effects treatment, but also the possibility shared etiology with other types cohort 525,527 was identified from 13 population-based registries Europe, Canada, Australia and Singapore, followed for second cancers within period 1943-2000. We used incidence rates first calculation standardized ratios (SIRs) Risk after various nonbreast...
Context: Increasing incidence and improved prognosis of thyroid cancer have led to concern about the development second primary cancers, especially after radioiodine treatment. Thyroid can also arise as a neoplasm other cancers. Objective: The objective study was assess risk vice versa. Design: This multinational record linkage study. Setting: conducted at 13 population-based registries in Europe, Canada, Australia, Singapore. Patients or Other Participants: A cohort 39,002 people (356,035...
<h3>Objectives</h3> The objective of this study was to examine the associations brain tumours with radio frequency (RF) fields from mobile phones. <h3>Methods</h3> Patients tumour Australian, Canadian, French, Israeli and New Zealand components Interphone Study, whose were localised by neuroradiologists, analysed. Controls matched on age, sex region allocated 'tumour location' their case. Analyses included 553 glioma 676 meningioma cases 1762 1911 controls, respectively. RF dose estimated as...
Importance Sepsis is associated with long-term cognitive impairment and worse psychological functional outcomes. Potential mechanisms include intracerebral oxidative stress inflammation, yet little known about the effects of early antioxidant anti-inflammatory therapy on cognitive, psychological, outcomes in sepsis survivors. Objective To describe observed differences vitamin C, thiamine, hydrocortisone between intervention control groups Vitamin Thiamine, Steroids (VICTAS) randomized...
Myelodysplastic syndrome (MDS) is considered to be very rare in children. However, the only two published population‐based studies reported widely divergent incidence figures. To further explore epidemiology of childhood MDS and evaluate accuracy cancer registry treatment trial data, we conducted a study children aged 0–14 years British Columbia (BC), Canada, between 1982 1996. was diagnosed 31 cases corresponding an annual 3.2 per million or 6% all leukaemias, compared with 6.0/million for...
An analysis of other primary cancers in individuals with non-Hodgkin's lymphoma (NHL) can help to elucidate this cancer aetiology. In all, 109 451 first NHL were included a pooled 13 registries. The observed numbers second compared the expected derived from age-, sex-, calendar period- and registry-specific incidence rates. We also calculated standardised ratios for as after cancers. There was 47% (95% confidence interval 43–51%) overall increase risk NHL. A strongly significant (P<0.001)...
Background: Leukemia is one of the most common potentially fatal illnesses in children, and its causes are not well understood. Although socioeconomic status (SES) has been related to leukemia some studies, this apparent association may be attributable ascertainment or participation bias. This study was undertaken determine whether there a difference incidence childhood for different levels SES, as measured by neighborhood income, an unselected population case group. Methods: All cases...
Abstract We investigated the risk of second malignancies among 29,511 survivors germ‐cell testicular cancer recorded in 13 registries. Standardized incidence ratios (SIRs) were estimated comparing observed numbers with expected obtained from sex‐, age‐, period‐ and population‐specific rates. Seminomas nonseminomas, 2 main histological groups cancer, analyzed separately. During a median follow‐up period 8.3 years (0–35 years), we 1,811 tumors, corresponding SIR 1.65 (95% confidence interval...
Survivors of childhood leukemia and lymphoma experience high risks second malignant neoplasms. We quantified such risk using a large dataset from 13 population-based cancer registries.The registries provided individual data on cases leukemia, Hodgkin lymphoma, non-Hodgkin occurring in children aged 0-14 years subsequent neoplasms for different time periods 1943 to 2000. Risks were assessed through standardized incidence ratios (SIRs) corresponding 95% confidence intervals (CIs), the rates...
Loss of income and out pocket expenses related to childhood cancer care can account for over 25% a family's total disposable income, adding the stress facing life-threatening disease. The objective this pilot study was assess impact on employment sources within families.A retrospective postal-administered questionnaire used collect information from parents children diagnosed with before 20 years age between 1990 1996 in province British Columbia (n = 111).Among full or part-time employed...
Abstract Our study examines inpatient, hospital‐related morbidity in a geographically‐defined cohort of long‐term cancer survivors diagnosed before age 20 years the province British Columbia (BC), Canada. A total 1374 from 1981 to 1995 surviving at least 5‐years postdiagnosis, and matched sample 13,740 BC residents, were identified population registers, linked provincial hospitalization records 1986 2000. Logistic regression was used assess relative risk effect sociodemographic, clinical,...
Objectives: The output power of a mobile phone is directly related to its radiofrequency (RF) electromagnetic field strength, and may theoretically vary substantially in different networks use circumstances due control technologies. To improve indices RF exposure for epidemiological studies, we assessed determinants multinational study. Methods: More than 500 volunteers 12 countries used Global System Mobile communications software-modified phones (GSM SMPs) approximately 1 month each. SMPs...
Increased survival of patients with childhood cancer has resulted in a growing population survivors within the education system, many whom may experience educational difficulties. The current study provides comprehensive assessment survivors' achievements.Seven hundred eighty-two from British Columbia (BC) Cancer Registry who attended BC schools 1995 to 2004, were compared randomly selected comparison group 8386 school children. Grade repetition, standard Foundation Skills Assessments (FSA),...
We undertook a re-analysis of the Canadian data from 13-country case-control Interphone Study (2001-2004), in which researchers evaluated associations mobile phone use with risks brain, acoustic neuroma, and parotid gland tumors. In main publication multinational Study, investigators concluded that biases errors prevented causal interpretation. applied probabilistic multiple-bias model to address possible simultaneously, using validation billing records nonparticipant questionnaires as...