A5012479141- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Stress Responses and Cortisol
- Neuroendocrine Tumor Research Advances
- Diabetes and associated disorders
- Hormonal and reproductive studies
- Myasthenia Gravis and Thymoma
- Diet and metabolism studies
- Ovarian function and disorders
- Sexual Differentiation and Disorders
- Vitamin K Research Studies
- Ophthalmology and Eye Disorders
- Cerebrospinal fluid and hydrocephalus
- Bone Tumor Diagnosis and Treatments
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Head and Neck Surgical Oncology
- Cardiac tumors and thrombi
University of Buenos Aires
2008-2019
Hospital de Clínicas "José de San Martín"
1985-2019
Favaloro Foundation
2015-2019
University of Padua
2018
Sociedad Española de Endocrinología y Nutrición
2017
Fundación para la Investigación, Docencia y Prevención del Cáncer
2017
National Food Administration
2015
Fundación Centro de Estudios Infectológicos
2012-2014
Hospital de Clínicas
2007-2013
Stockholm University
2010-2013
To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects temozolomide (TMZ) treatment.Electronic survey to ESE members Dec 2015-Nov 2016.Reports on 166 (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% the clinically functioning, most frequent immunohistochemical subtype corticotroph (45%). Ki-67 index did not distinguish APT from median 7% 10%...
Cabergoline is a long-acting dopamine receptor agonist used to treat prolactinomas. Identification of D(2) receptors in corticotroph tumors led clinical trials cabergoline therapy limited cases Nelson's syndrome, ectopic ACTH-secreting tumors, and recently Cushing's disease (CD).To evaluate the long-term efficacy monotherapy patients with CD.Retrospective analysis non-randomized 30 CD treated academic centers Buenos Aires Montreal. was initiated at 0.5-1.0 mg/week adjusted up maximal dose 6...
Freshwater blooms of cyanobacteria (blue-green algae) in source waters are generally composed several different strains with the capability to produce a variety toxins. The major exposure routes for humans direct contact recreational and ingestion drinking water not efficiently treated. ultra high pressure liquid chromatography tandem mass spectrometry based analytical method presented here allows simultaneous analysis 22 cyanotoxins from toxin groups, including anatoxins,...
We evaluated results of temozolomide (TMZ) therapy in six patients, aged 34–78 years, presenting aggressive pituitary tumors. In all the patients tested O 6 -methylguanine-DNA methyltransferase (MGMT) immunoexpression surgical specimens was absent. Patients received 140–320 mg/day for 5 days monthly at least 3 months. two minimum time evaluation could not be reached because death a 76-year-old man with malignant prolactinoma and severe neutro-thrombopenia 47-year-old woman nonfunctioning...
Most autonomous functioning thyroid nodules (AFTN) are benign follicular neoplasms. There rare reports of malignant hot nodules, in which activating mutations the TSH receptor (TSHR) were found. We report a case carcinoma presenting as an AFTN causing subclinical hyperthyroidism 64-year-old woman who had 6-cm nodule left lobe. Genomic DNA was extracted from paraffin-embedded tissues tumor and extratumoral tissue. Sequence analyses revealed point two different genes: normal ACC sequence at...
Abstract. Seventeen patients with well-proven Cushing's syndrome (13 disease, 3 adrenal tumour and 1 presenting ectopic ACTH caused by bronchial carcinoid) were investigated using a single-dose 8 mg dexamethasone nocturnal test. The results obtained compared those of the classical Liddle's test, metyrapone stimulation, plasma concentration final diagnosis reached through surgery, pathologic anatomy, and/or clinical biochemical follow-up after treatment. diagnostic efficacy or predictive...
To describe the long term safety and efficacy of pegvisomant (PEGV), predictors treatment response in patients with acromegaly real life setting.We retrospectively reviewed clinical, hormonal radiological data acromegalic treated PEGV 17 Argentine centers.Seventy-five (age range 22-77, 51 females) have been for up to 118 months (median 27 months). Before PEGV, 97.3% had medical therapy, surgery and/or radiotherapy, two no previous treatment. At that time, all an IGF-1 above upper normal...
Extra-adrenal effects of high doses oral metyrapone (6 g over 210 min) were investigated in 9 normal subjects. Plasma sugar increased markedly. cortisol fell dramatically from 12.3±1.7 μg/100 ml (mean±sem) at 0 min to 6.6±1.1 30 and 3.0±0.6 60 min. The disappearance half-time endogenous plasma, calculated the 0–30 period, averaged 32 (range 22–49 min). This acceleration plasma was confirmed by control studies with labeled performed 3 These data strongly suggest an extra-adrenal action upon...