Miklós Góth
A5040992376- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Thyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- Hypothalamic control of reproductive hormones
- Childhood Cancer Survivors' Quality of Life
- Endometriosis Research and Treatment
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Regulation of Appetite and Obesity
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Dermatological and COVID-19 studies
Cliniques Universitaires Saint-Luc
2019-2023
Lohmann (Germany)
2023
Institut für Frauengesundheit
2018-2020
Universitätsklinikum Tübingen
2018-2020
Wroclaw Medical University
2018
Buda Health Center
2016
BM Központi Kórház
2011-2012
Molina Center for Energy and the Environment
2012
Állami Szívkórház
2010
Health Center
2009
GH secretion has been thought traditionally to be regulated by the two hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin (SRIF). Recent evidence suggested that other factors may involved. These include natural ligand for synthetic hexapeptide peptide (GHRP) putative hypophysiotropic factor pituitary adenylate cyclase-activating polypeptide (PA-CAP). Accordingly, we examined effects of GHRP PACAP on at single cell level using reverse hemolytic plaque assay which allows...
A novel oral octreotide formulation was tested for efficacy and safety in a phase III, multicenter, open-label, dose-titration, baseline-controlled study patients with acromegaly.We enrolled 155 complete or partially controlled (IGF-1 <1.3 × upper limit of normal [ULN], 2-h integrated GH <2.5 ng/mL) receiving injectable somatostatin receptor ligand (SRL) ≥ 3 months. Subjects were switched to 40 mg/d capsules (OOCs), the dose escalated 60 then up 80 control IGF-1. Subsequent fixed doses...
Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease. To determine the mutational status FIPA and young patients, analyzing their clinical characteristics, perform AIPmut carrier family members. This was observational, longitudinal study conducted...
Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascades are key signalling pathways interacting with each other to regulate cell growth tumourigenesis. We have previously shown B-Raf Akt overexpression and/or overactivation in pituitary adenomas. The aim this study is assess the expression their downstream components (MEK1/2, ERK1/2, mTOR, TSC2, p70S6K) effectors (c-MYC CYCLIN D1). studied tissue from 16 non-functioning adenomas (NFPAs), six...
Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment acromegaly and administered by deep sc injection from small volume, prefilled syringe. The aim this study was to evaluate efficacy safety formulation in large population acromegalic patients previously responsive 30 mg, im (sustained release microparticle formulation). every 28 d 107 (54 males 53 females; mean age, 54 ± 1.2 yr). All had been treated with (30 mg) at least 3 months before entry GH level...
To investigate the effect of varying amounts iodine intake on prevalence thyroid dysfunction, autoimmunity and goitre in old age.The first screening study where elderly subjects with supply but from same geographical ethnographical region (Carpathian basin) were compared, all hormone measurements ultrasonography performed by laboratory or person.Nursing home residents screened for disorders from: (A) an iodine-deficient area, Northern Hungary (n = 119; median age 81 years; excretion (MIE)...
The aim of the present study was to clarify relationship between GH deficiency (GHD) and some cardiovascular risk factors analyse effect replacement therapy in a large number patients over prolonged period time.Data for analysis were retrieved from KIMS (Pfizer International Metabolic Database). Serum concentrations total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density (LDL)-cholesterol triglycerides obtained 2589 at baseline 1206 after 1 2 years therapy. Body mass index...
The study was designed to evaluate the long-term efficacy and safety of 28-day prolonged-release Autogel formulation somatostatin analogue lanreotide (Lan-Autogel) in unselected patients with acromegaly. comprised four phases: washout; a double-blind comparison placebo, at single randomized dose (60, 90 or 120 mg) Lan-Autogel; single-blind, fixed-dose phase for injections (placebo group re-allocated active treatment); eight doses tailored according biochemical response. Serum samples were...
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (&lt;65...
The prevalence of thyroid microcarcinomas found at autopsies is 100–1000 times higher than in clinical cancer. epidemiological and histological characteristics consecutive series performed two areas different iodine intake were investigated. Iodine deficient (ID) area: n = 222 (M 109, F 113), median age: 74–76 years, excretion (MIE) nursing home residents from this 70 µg/g creatinine. sufficient (IS) 221 132, 89), 68 MIE: 500 When compared to the IS area, results obtained ID area showed a...
Somatostatin (SST) analogues play an important role in the medical management of somatotroph pituitary adenomas and new agonists have potential to be effective a wider group other tumours. The anti-proliferative effect SST occurs through multiple mechanisms, one which is cell-cycle arrest, where p27, cyclin-dependent kinase inhibitor, regulator. We hypothesised that may upregulate p27 protein levels downregulate MAP pathway these tumours.Human adenoma cells rat cell line (GH3) were cultured...
OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence diabetes during GH replacement therapy (GHRT) effect GHRT on fasting plasma glucose concentrations HbA1c in adult patients deficiency. RESEARCH DESIGN AND METHODS A total 5,143 GH-deficient (male 49.9%; mean age ± SD, 49 13 years; BMI 29.1 5.9 kg/m2) were analyzed. Mean observation period 3.9 years (range 0.01–13). Total number patient-years...
Objective An increased risk of cardiovascular morbidity and mortality in adult GH deficiency (GHD) may be related to hypopituitarism but also the presence metabolic syndrome (MetS). Our objective was investigate characteristics prevalence MetS as well its comorbidities GHD. Design In KIMS (Pfizer International Metabolic Database) 2479 patients with severe adult-onset GHD, naïve replacement, complete information on all components were found. defined according National Cholesterol Education...
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
GH deficiency (GHD) in adults is characterized by a tendency toward obesity and an adverse body composition with visceral fat deposit may thus predispose to the development of type 2 diabetes mellitus. The aim this study was assess observed prevalence proportion (PP) PP over expected ratio (standardized ratio, SPR) according International Diabetes Federation criteria large cohort GH-untreated adult-onset GHD patients.Associations between baseline variables 6050 patients from KIMS (Pfizer...
Eur J Clin Invest 2012 Abstract Purpose While pituitary adenomas are common, carcinomas rare. It is unclear whether arise de novo or evolve from adenomas. Methods We studied the clinical characteristics and tissue samples eight surgeries autopsy a patient with carcinoma. A 16‐year‐old female was diagnosed an aggressive Crooke cell macroadenoma. Following transsphenoidal surgery, signs of Cushing disease quickly reappeared. During 14‐year course illness, surgeries, three courses extracranial...
Objective Growth hormone (GH) replacement therapy currently requires daily injections, which may cause distress and low compliance. C-terminal peptide (CTP)-modified growth (MOD-4023) is being developed as a once-weekly dosing regimen in patients with GH deficiency (GHD). This study’s objective to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD) efficacy of MOD-4023 administered GHD adults. Design 54 adults treated were normalized randomized into 4 weekly cohorts at 18.5%,...
Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical (PMT) affects postoperative outcome remains controversial.(1) Evaluate how frequently PMT given to CS patients across Europe; (2) examine differences in characteristics who receive and those undergo primary surgery (3) determine if influences pituitary-dependent (PIT-CS).1143 entered into ERCUSYN database from 57 centers 26 countries....
Objective : Sheehan’s syndrome occurs as a result of ischaemic pituitary necrosis due to severe postpartum haemorrhage. It is one the most important causes hypopituitarism, and hence growth hormone deficiency (GHD), in developing countries. However, little known about effects (GH) replacement therapy patients with syndrome. Design The demographic background characteristics 91 GH-deficient (mean age ± s.d. , 46.3 9.4 years) were compared those group 156 women 51.5 13.1 non-functional adenoma...
A voice assessment was performed before and after conservative treatment in 3 male-to-female transsexuals 2 nontreated serving as control persons. The characteristics studied were quality, habitual speaking pitch, vocal pitch range, intensity maximum phonation time ‘communicative impairment’, a subjective self-estimation by the patient. Based on these parameters Friedrich dysphonia index (DI) calculated. of who had received became female, contrast to that transsexuals, which remained...
To assess its differential diagnostic value, dehydroepiandrosterone sulfate (DHEA-S) was measured in a nonselected cohort of 84 patients with incidentally detected adrenal tumors (incidentaloma). Of the 38 histologically confirmed cases, 6 12 primary or metastatic malignant tumor adrenals and 7 14 benign cortical adenoma had low DHEA-S levels. Thus, sensitivity, specificity, predictive value level to indicate were 0.35, 0.50, 0.60, values 0.67, 0.47, respectively. cases adenoma, 10 signs...