A5071301954- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Diabetes Management and Research
- Animal Nutrition and Health
- Effects of Environmental Stressors on Livestock
- Animal health and immunology
- Viral gastroenteritis research and epidemiology
- Milk Quality and Mastitis in Dairy Cows
- Digestive system and related health
- Pituitary Gland Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Veterinary Medicine and Surgery
- Pharmacological Effects of Natural Compounds
- Growth Hormone and Insulin-like Growth Factors
- Agriculture and Biological Studies
- Diabetes and associated disorders
- Reproductive Physiology in Livestock
- Veterinary Pharmacology and Anesthesia
- Pancreatic function and diabetes
- Veterinary Oncology Research
- Adrenal Hormones and Disorders
- Microbial infections and disease research
- Food Industry and Aquatic Biology
G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms
2022-2024
Peoples' Friendship University of Russia
2020-2024
Institute of Bioorganic Chemistry
2019-2023
Moscow State Academy of Veterinary Medicine and Biotechnology named after Skryabin
2021-2023
University of Tartu
2023
University Hospital Kralovske Vinohrady
2023
Universitat Autònoma de Barcelona
2023
Scientific Research Institute of Biochemistry
2023
Pushchino State Institute of Natural Sciences
2020-2021
Institute of Bioorganic Chemistry
2020-2021
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Mastitis is one of the most important diseases cows and expensive pathology for dairy industry. Therefore, this study was conducted to explore role microorganisms isolated from with mastitis in formation biofilms under conditions farm biogeocenosis Moscow region.Periodic visits 12 farms region were microbial profile udder mastitis. During visits, 103 milk samples sick animals collected examined. Through microbiological analyses, 486 cultures identified, which are assigned 11 genera. caused...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (<65...
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
The processes of lipid peroxidation (POL) form the basis damage to cell membranes. antioxidant system (AOS) is a multicomponent for regulating oxygen activation processes, without which normal functioning body would be impossible. state and physiological course vital depend on balance stability between POL–AOS systems. imbalance these systems determines clinical manifestation, progression, severity, prognosis any inflammatory process in body. aim work was determine products activity calves...
Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical (PMT) affects postoperative outcome remains controversial.(1) Evaluate how frequently PMT given to CS patients across Europe; (2) examine differences in characteristics who receive and those undergo primary surgery (3) determine if influences pituitary-dependent (PIT-CS).1143 entered into ERCUSYN database from 57 centers 26 countries....
Despite the introduction of modern methods treatment, creation new generations antibacterial agents, and constant improvement aseptic antiseptic methods, treatment purulent–inflammatory processes remains one most complex urgent problems in veterinary practice. The article presents results isolation indigenous microbiota from various biotopes healthy cats, as well study their biological marker properties for selection optimal strains probiotic medicines control surgical infections. It was...
Background: Dilated cardiomyopathy is common in dogs. This form of the main cause death due to heart disease Death can occur suddenly clinically normal animals as a result progression congestive failure (CHF). The pathogenesis syndrome dogs with dilated involves activation neurohumoral system and immune-mediated inflammation, which leads further condition. Heart caused by progressive loss cardiomyocytes, apoptosis, remodeling left ventricle, systolic diastolic dysfunction, arrhythmias,...
The work aimed to determine the state of lipid peroxidation products and activity antioxidant system in cats with aseptic inflammation purulent-inflammatory processes varying severity.The intensity process peroxidation- blood plasma was evaluated using commercial kits. level diene conjugates (DC), content malondialdehyde (MDA), medium-weight molecules were determined from indices. protection assessed by indicators superoxide dismutase (SOD) activity, catalase (CT), ceruloplasmin (CP)...
Recent studies have shown that the gut microbiota plays an important role in pathogenesis of gastrointestinal diseases various animal species. There are only limited data on microbiome cats with varying grades dysbiosis. The purpose study was a detailed analysis quantitative and qualitative fecal spectrum intestinal dysbiosis severity. obtained indicate that, depending severity cats, landscape changes significantly. It has been established severity, there is shift balance between...
CO2 inhalation is currently the most common method of euthanasia for laboratory rats and mice, it often used further terminal blood sampling clinical biochemical assays. Lately, this has been criticized due to animal welfare issues associated with some processes that develop after inhalation. The stress reaction value parameters significantly depend on anesthetics, method, site sampling. Especially in small rodents, an acute state followed by a cascade metabolic reactions can affect studied...
Introduction: The article presents the results of functional tests to improve assessment MIA-induced osteoarthritis development and effectiveness NSAID therapy.
 Materials methods: In study, 26 male SD rats were used. osteoarthritis was simulated in right knee joint. After an intra-articular injection MIA, animals treated with ibuprofen meloxicam. Pain studied following tests: incapacitance (hind limb weight bearing) test, von Frey test (mechanical allodynia), grip strength diameter...
At the present stage of development market economy, one most important tasks agricultural sector in Russia is to increase production products, which depends on sustainable livestock industries and their intensification based modern achievements. The agro-industrial complex its basic type economic activity - agriculture are leading system-forming spheres economy Chuvash Republic, form agri-food market, food security, labor settlement potential rural territories. One Republic State program...
The development of new herbal preparations for the treatment urolithiasis is an urgent task medical science. Ficus have attracted attention pharmacologists due to a wide range biological properties, including antioxidant, anti-inflammatory, antibacterial and antifungal activity. We studied effectiveness
The aim of the study was to search for, isolate and characterize new bacteriolytic enzymes that show promising potential for their use in medicine, agriculture veterinary. Using a transcriptomic analysis, we annotated Lysobacter capsici VKM B-2533T genes known antifungal enzymes, as well antibiotics, whose expression levels increased when cultivated on media conducive production antimicrobial agents. secreted putative proteases were also annotated. Two proteases, Serp Serp3, isolated...
Research on the study of parasitocenoses in endometritis and mastitis cows, as well gastrointestinal respiratory diseases newborn calves, were carried out 12 farms Moscow region with a total number 4,445 cows 12,254 cattle. It was found that parasitocenosis cattle are vulnerable to factor infections composed S. agalactiae, dysgalactiae, uberis, pyogenes, pneumoniae, faecalis, aureus, albus, saprophyticus, epidermidis, intermedius, enterica (S. enteritidis, typhimurium, dublin), E. coli (O1,...
Hardware-software test bench for experimental approbation of methods improving accuracy BG measurement by optical non-invasive glucometer was developed. The comprises hard PVC rail, sliding carriages with holders flow-through cuvettes, light source and photodiode. Test solution glucose other blood substances are circulated between constant-temperature reservoir stirring the cuvette. To control system computer interface Software user allows setting modes provides real-time visualization...
The article presents data on biocenotic diagnostics of 12 farms in the Moscow region that are endowed with endometritis and mastitis cows, as well gastrointestinal respiratory diseases newborn calves, aim identifying zoo-hygienic, zootechnical veterinary deficiencies to optimize strategy for dealing them. Studies biocenoses were carried out unsuccessful cows’ obstetric gynecological diseases, a total number cattle 254, including 4445 cows. For this purpose, field trips periodically...