Irina Komerdus
A5081805363- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Hormonal Regulation and Hypertension
- Myasthenia Gravis and Thymoma
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
- Diet and metabolism studies
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Ophthalmology and Eye Disorders
- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Urticaria and Related Conditions
- Pancreatitis Pathology and Treatment
- Ion channel regulation and function
- Medical and Biological Sciences
- Chronic Lymphocytic Leukemia Research
Regional Clinical Research
2007-2024
Centre for Biomedical Network Research on Rare Diseases
2023
Instituto de Salud Carlos III
2023
Hospital Universitari Germans Trias i Pujol
2023
Buda Health Center
2023
Evangelismos Hospital
2023
University of Milan
2023
Jagiellonian University
2023
Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky
2016-2017
Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time death in a large cohort patients CS establish factors associated mortality.In study, we analyzed 1564 included European Registry on (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent 89 (5%) an ectopic source 45 (3%) other causes. median (IQR) overall follow-up ERCUSYN 2.7 (1.2-5.5) years.Forty-nine died at analysis; 23 (47%) 6 (12%) 18 (37%)...
Abstract Objective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies patients with Cushing's syndrome (CS) included the European Registry on Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent (ADR-CS), 107 (6%) an ectopic source (ECT-CS). According to WHO criteria, 1616 (90.2%) were classified as younger (<65...
To evaluate which tests are performed to diagnose hypercortisolism in patients included the European Registry on Cushing's syndrome (ERCUSYN), and examine if their use differs from current guidelines.We analyzed data diagnostic 1341 with (CS) who have been entered into ERCUSYN database between January 1, 2000 31, 2016 57 centers 26 countries. Sixty-seven percent had pituitary-dependent CS (PIT-CS), 24% adrenal-dependent (ADR-CS), 6% an ectopic source (ECT-CS) 3% were classified as having...
Abstract Objective The aim of this study was to evaluate the prevalence venous thromboembolism (VTE) in patients included European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design A retrospective observational cohort study. Methods Data extraction from registry taken February, 7, 2022. At time there were 2174 diagnosed (CS) 95 VTEs reported database. Results Of events 70 (74%)...
Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into European Registry on (ERCUSYN) to evaluate if patients CS pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than adrenal causes (ADR-CS). Data from 595 (492 women; 83%) who completed CushingQoL and/or EQ-5D questionnaires at baseline following were analysed. At baseline, HRQoL did not...
Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical (PMT) affects postoperative outcome remains controversial.(1) Evaluate how frequently PMT given to CS patients across Europe; (2) examine differences in characteristics who receive and those undergo primary surgery (3) determine if influences pituitary-dependent (PIT-CS).1143 entered into ERCUSYN database from 57 centers 26 countries....
Background: Ectopic adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome is a type hypercorticism caused by ectopic production of ACTH and/or its precursors neuroendocrine tumors (NET) various localization, such as lung and thymus carcinoids, less frequently those pancreas gastrointestinal tract, medullary thyroid cancer, pheochromocytoma, small cell well some other tumor types. The wide spectrum associated with the (EAS) makes their diagnosis treatment complicated issue....
Cushing’s disease is a rare severe neuroendocrine disorder caused by chronic overproduction of adrenocorticotropic hormone pituitary tumor. Supraphysiological concentrations cortisol in endogenous hypercortisolism have an immunosuppressive and anti-inflammatory effect similar to therapy with systemic glucocorticosteroids. This may reduce the activity patient’s concomitant autoimmune inflammatory diseases. On other hand, decrease levels during treatment for be associated reactivation immune...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
21 patients with Graves’ disease and ophthalmopathy (GO) received radioiodine treatment (RIT). Before 131-I therapy in all GO were non-active no severe. Six not any before RIT; four orbital radiotherapy 11 intravenous glucocorticoids. Thyreotoxicosis compensation achieved by antithyroid medication RIT. Antithyroid was stopped 10 days Worsening of seen on 47.7% 3 months after RIT, but only 9.5% needed additional GO. exacerbation take place 90% hypothyroid its reduced the symptoms activity for...
Актуальность. С учетом того, что многие психофизиологические параметры напрямую зависят как от тяжести патологического процесса и его длительности, так эффективности проводимого лечения, весьма актуальны исследования, оценивающие отдаленные результаты, а также показатели качества жизни, связанного со здоровьем, психоэмоциональный статус в сроки после радикального лечения у больных с диффузным токсическим зобом. Цель – анализ безопасности радикальных методов диффузного токсического зоба,...
Background: Cushing's disease (CD) is a severe multimorbid disorder that affects primarily young people in their productive age. In most cases, the diagnosis delayed and patients with complications of hypercorticism are seen by doctors various specialties. Aim: To identify frequent clinical signs symptoms CD at time diagnosis, to assess an association between manifestations main laboratory parameters. Materials methods: We examined 44 registered database Moscow Regional Research Clinical...
This paper summarizes the original clinical experience of authors concerning differential diagnostics ACTH-dependent hypercortisolism. A total 8 patients were available for estimation potential such with use high-dose dexamethasone suppression test, pituitary MRI, and selective blood sampling from inferior petrosal sinuses determination ACTH concentration gradient between central peripheral compartments. It turned out that neither test nor MRI provided unambiguous information about source...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)