A5088721373- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Adrenal Hormones and Disorders
- Cerebrospinal fluid and hydrocephalus
- Inflammation biomarkers and pathways
- Moyamoya disease diagnosis and treatment
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Genetic Syndromes and Imprinting
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Parathyroid Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
- Hormonal Regulation and Hypertension
- Steroid Chemistry and Biochemistry
- MRI in cancer diagnosis
- Advanced Fluorescence Microscopy Techniques
- Diet and metabolism studies
- Congenital heart defects research
Endocrinology Research Center
2013-2024
Ministry of Health of the Russian Federation
2016-2021
Faculdades Guarulhos
2016-2018
Russian Academy of Sciences
2008
Abstract Context Pituitary blastoma is a rare, dysontogenetic hypophyseal tumor of infancy first described in 2008, strongly suggestive DICER1 syndrome. Objective This work aims to describe genetic alterations, clinical courses, outcomes, and complications all known pituitary cases. Design Setting A multi-institutional case series presented from tertiary pediatric oncology centers. Patients included children with blastoma. Interventions Genetic testing, surgery, oncologic therapy, endocrine...
Current dissociation methods for solid tissues in scRNA-seq studies do not guarantee intact single-cell isolation, especially sensitive and complex human endocrine tissues. Most rely on enzymatic of fresh samples or nuclei isolation from frozen samples. Dissociating whole cells fresh-frozen samples, commonly collected by biobanks, remains a challenge. Here, we utilized the acetic-methanol approach (ACME) to capture transcriptional profiles individual tissue This method combines acetic...
Corticotropinomas and adrenocorticotropic hormone (ACTH)-secreting neuroendocrine tumors exhibit differential levels of some microRNAs (miRs) compared to normal tissue. Because miRs can be released from tissues into circulation, they offer promise as novel disease biomarkers. Objective: To evaluate whether are differentially detected in plasma samples patients with ACTH-dependent Cushing's syndrome (CS) Design: Case-control study Methods: Morning fasting were collected 41 consecutive...
We recommend acromegaly to be ruled in all patients with characteristic changes appearance (A3). In without appearance, we rule out acromegaly, if several clinical signs suspicious for are present (B3). pituitary adenoma prolactin-secreting adenomas (C4). For laboratory confirmation of measure serum insulin-like growth factor-1 (IGF-1, somatomedin C) level obvious and/or a moderate increase IGF-1 levels (IGF-1 index less than 1.3), assess the response somatotropic hormone (GH) hyperglycemia...
AIM: To analyze the diagnostic performance of bilateral inferior petrosal sinus sampling (BIPSS) with desmopressin as a stimulation agent and prolactin measurements to control catheter position or without ACTH/prolactin normalized ratio calculation in differential diagnosis ACTH-dependent endogenous hypercortisolism, diagnostics ectopic ACTH-syndrome (EAS) visualization. MATERIALS AND METHODS: A single-center study retrospective analysis data was carried out. The included patients...
Abstract Current scRNA-seq studies of solid tissues mostly rely on enzymatic dissociation fresh samples or the fallback nuclei isolation from frozen partially fixed samples. However, due to complex tissue organization cell fragility, it could be challenging apply these approaches sensitive endocrine tissues. That is, dissociating intact cells such problematic fresh-frozen routinely collected by biobanks remains challenging. In this study, we adapted acetic-methanol method – ACME High Salt...
This paper highlights the problem of neuroendocrine tumours (NETs) with clinical symptoms hypercorticism caused by hypersecretion adrenocorticotropic hormone (ACTH) tumour cells. In most cases (85%), were localized in pituitary gland (Cushing's disease); 15% patients had an extrapituitary that manifest as ectopic ACTH secretion (EAS). Comparative analysis clinical, hormonal, histological, and immunohistochemical characteristics ACTH-secreting NET was performed. It included 46 CD 38 ones...
Background: Ectopic adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome is a type hypercorticism caused by ectopic production of ACTH and/or its precursors neuroendocrine tumors (NET) various localization, such as lung and thymus carcinoids, less frequently those pancreas gastrointestinal tract, medullary thyroid cancer, pheochromocytoma, small cell well some other tumor types. The wide spectrum associated with the (EAS) makes their diagnosis treatment complicated issue....
Abstract Context Excessive production of growth hormone causes marked multiorgan changes in patients with acromegaly, which may involve epigenetic mechanisms. Objective To evaluate differences circulating microRNAs (miRNAs) associated chronic overproduction adults. Design and Setting A cross-sectional case-control study was conducted at a tertiary medical center. Participants We enrolled 12 consecutive acromegaly along age- sex-matched controls the discovery phase then extended this cohort...
Обоснование. Болезнь Иценко–Кушинга (БИК) – тяжелое многосимптомное заболевание гипоталамо-гипофизарно-надпочечниковой системы. Причиной заболевания является наличие аденомы гипофиза (кортикотропиномы). Увеличение секреции адренокортикотропного гормона (АКТГ) аденомой приводит к повышенной кортизола корой надпочечников и развитию тотального эндогенного гиперкортицизма. Золотым стандартом лечения данного хирургическое удаление кортикотропиномы. Однако аденомэктомия не во всех случаях бывает...
BACKGROUND : Thyrotropin-secreting pituitary adenomas (TSH-PA) are a rare cause of thyrotoxicosis and account for 0.5-2% all adenomas. Taking into the rarity disease, it is extremely important to analyze each case TSH-PA. AIM: To clinical characteristics treatment outcomes patients with TSH-PA, as well determine preoperative early postoperative factors that predict long-term remission. MATERIALS AND METHODS In single-center retrospective study we analyzed signs, laboratory instrumental...
BACKGROUND: microRNA is a class of small non-coding RNA molecules involved in posttranscriptional regulation gene expression. MicroRNAs are detectable blood stable concentrations, which makes them promising biomarkers for various diseases. AIM: to assess plasma expression patients with active acromegaly compared healthy controls. MATERIAL AND METHODS: single-center, case-control study: assessment Fasting samples were drawn and centrifuged at +5С temperature 3000 rpm 20 minutes, then...
Ectopic secretion of ACTH from non-pituitary tumors, referred to as ectopic syndrome (EAS), accounts for about 10–20% Cushing’s (CS). hormone-secreting pheochromocytomas (Pheo) are rare. The first publication association between pheochromocytoma and by Roux is dated 1955. Pheochromocytoma represents a rare cause hypercortisolism, accounting less than 5 % while 1 accompanied syndrome.We reporting 4 cases ACTH-secreting presenting syndrome. Data patients were analysed. There women 50 63 years...
BACKGROUND : For the last decades microRNAs (miR) have proven themselves as novel biomarkers for various types of diseases. Identification specific circulating microRNA panel that differ patient with Cushing’s disease (CD) and ectopic ACTH syndrome (EAS) could improve diagnostic procedure. AIM to evaluate differences in miR levels plasma samples drained from inferior petrosal sinuses patients CD EAS. MATERIALS AND METHODS single-center, case-control study: we enrolled 24 ACTH-dependent (CS)...
Наиболее часто первичный гиперпаратиреоз (ПГПТ) в сочетании с раком (как правило, медуллярным) щитовидной железы (ЩЖ) встречается при синдромах множественных эндокринных неоплазий. Сочетание немедуллярных карцином ЩЖ и ПГПТ отмечается у 3% пациентов. Доля папиллярного рака (ПР) достигает 87% от всех ее злокачественных опухолей. Атипическая аденома (АА) околощитовидной (ОЩЖ) – это новообразование, котором отсутствуют достоверные признаки инвазивного роста, но есть морфологические критерии,...
Hyperandrogenism is the most prevalent cause of menstrual cycle abnormalities and infertility in women. Here, we present a case 32-year-old woman with 7-year history irregularity infertility. Laboratory test results revealed elevated 17-hydroxyprogesterone, progesterone 21-deoxycortisol. Abdominal computed tomography found 3,9х2,9х2,6 cm left adrenal tumor. Non-classic congenital hyperplasia was diagnosed initially, however, treatment supraphysiological doses dexamethasone proved ineffective...
Acromegaly is a neuroendocrine disorder caused by excessive production of growth hormone (GH). In the majority cases cause acromegaly pituitary tumor producing GH. Cases ectopic are much rarer. Ectopic occurs in tumors which produce hormone-releasing (GHRH) or extrapituitary The main sources GHRH (NETs) lung pancreas. Treatment consists surgical removal source hyperproduction and where surgery not an option, somatostatin analogues, pegvisomant, chemotherapy, immunotherapy radiation therapy...
The prevalence of pituitary adenomas in the population among tumors central nervous system is about 17%. Pituitary are divided into non-functional (about 36–54%), characterized by absence secretory activity, and functional 46–64%), secreting hormones or their subunits. most common prolactinomas (32–51%), somatotropinomas (9– 11%), corticotropinomas (3–6%), frequency gonadotropins thyrotropins low amounts to less than 1% cases. This article presents a clinical observation patient with...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Introduction. Timely differential diagnosis between densely and sparsely granulated somatotrophic tumors allows predicting the most probable scenario of acromegaly course, receptor phenotype proliferative potential tumor cells, risk continued postoperative growth, as well efficacy planned drug therapy with first-generation somatostatin ligands. Aim. To validate cytological, radiological therapeutic predictors allowing to evaluate morphofunctional composition predict sensitivity Materials...
In the article, a clinical case of hormonally inactive tumor posterior pituitary is described. The symptoms were caused by mass effect (chiasma compression and hypopituitarism). Transnasal transsphenoidal adenomectomy was performed on patient. Subsequent morphologic examination revealed solid neoplasm large cells with broad oxyphilic granular cytoplasm, presumably originating from adenohypophysis cells. By immunohistochemical examination, pituicytoma, cell pituitary, diagnosed. Hence,...
According to numerous studies, the most common pituitary tumors are prolactinomas, reaching 60% of all clinically significant adenomas, next in order non-functional somatotropinomas, corticotropinomas and thyrotropinomas. Plurigormonal occur less than 1% adenomas. The form mixed secretion adenoma this patient population, derived from Pit-1 cell line, produces various combinations hormones: growth hormone (GH), prolactin (PRL), thyroid-stimulating (TSH). This article presents a with...