A5027014087- Parathyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Bone health and osteoporosis research
- Neuroblastoma Research and Treatments
- Bone Metabolism and Diseases
- Growth Hormone and Insulin-like Growth Factors
- Fibroblast Growth Factor Research
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Medical and Biological Sciences
- Genetic Syndromes and Imprinting
- Glioma Diagnosis and Treatment
- Digestive system and related health
- Cytokine Signaling Pathways and Interactions
- Bioinformatics and Genomic Networks
- Pancreatic and Hepatic Oncology Research
- Vitamin D Research Studies
- Dermatological and Skeletal Disorders
- Adrenal Hormones and Disorders
- Radiomics and Machine Learning in Medical Imaging
Endocrinology Research Center
2015-2024
Ural State Medical University
2022
Sechenov University
2022
Ministry of Health of the Russian Federation
2015-2016
Screening using the Fracture Risk Assessment Tool (FRAX) is recommended in all postmenopausal woman and mеn over 50 (A1) order to identify individuals with high probability of fractures. It diagnose osteoporosis start treatment patients fragility fracture large bones skeleton and/or individual major fractures detected decrease bone mineral density (BMD) up –2.5 T-score as assessed by DXA femoral neck lumbar vertebrae (A1). Patients back pain, lifetime height loss 4 cm or 2 since a previous...
Due to continuous aging of population and increase in the number elderly people, osteoporosis became socially significant disease leading disability, increasing mortality thereby putting an additional burden on public healthcare system. Screening identify groups with a high probability fracture is recommended using FRAX ® Tool for all postmenopausal women men over 50 years old (А1). In presense major pathological fractures (hip, spine, multiple fractures) it diagnose prescribe treatment...
Primary hyperparathyroidism (PHT) is the third most common endocrine disorder in men and women after diabetes mellitus thyroid disease one of frequent causes osteoporosis fractures among secondary osteopathy. PHT refers to socially significant problems connection with involvement pathological process majority organs system In recent years, conception epidemiology, clinic tactics management patients has changed due increase morbidity at expense identification mild forms disease. The modern...
The article presents a draft of clinical recommendations for the diagnosis and treatment primary hyperparathyroidism in adult patients, which provides modern examination algorithm, discusses basic principles laboratory, instrumental diagnostics approaches.
Parathyroid carcinoma is an extremely rare disorder with little treatment options. It could be misdiagnosed in medical centers experience management of such cases. Our clinical case shows that the initial misdiagnosis a parathyroid young woman has led to development multiple lung metastases, thus making its hardly possible. Initiation sorafenib - multi-kinase inhibitor approved for different types cancer but not significant decrease size metastases and prevented progression...
Introduction: Tumor-induced osteomalacia is an acquired rare disease manifested by hypophosphatemic due to excessive secretion of fibroblast growth factor 23 (FGF23). FGF a non-classical hormone secreted bone tissue (osteocytes) and regulates phosphorus metabolism. The aim this work present clinical experience in the diagnosis, treatment rehabilitation patients with tumor-induced osteomalacia. Materials methods : 40 clinically-confirmed were included study, 34 whom had tumor localized, 27...
We recommend acromegaly to be ruled in all patients with characteristic changes appearance (A3). In without appearance, we rule out acromegaly, if several clinical signs suspicious for are present (B3). pituitary adenoma prolactin-secreting adenomas (C4). For laboratory confirmation of measure serum insulin-like growth factor-1 (IGF-1, somatomedin C) level obvious and/or a moderate increase IGF-1 levels (IGF-1 index less than 1.3), assess the response somatotropic hormone (GH) hyperglycemia...
Primary hyperparathyroidism (PHPT) is a relatively rare disorder among children, adolescents and young adults. Its development at an early age suspicious for hereditary causes, though the need routine genetic testing remains controversial.To identify describe forms of PHPT in patients with manifestation disease under 40 years age.We enrolled 65 diagnosed before age. Ten them had MEN1 mutation, was first multiple endocrine neoplasia type 1 syndrome.The other fifty-five underwent...
BACKGROUND: The registry is the main source of information about patients with acromegaly for assessing quality medical care, effectiveness treatment, determining compliance real clinical practice existing standards and patient management protocols. AIMS: To evaluate epidemiological, demographic characteristics in Russian Federation treatment modalities. MATERIALS AND METHODS: object study was database united pituitary tumors specific analysis only. We analyzed data 4114 stored on online...
A summary of the draft federal clinical guidelines on osteoporosis developed by members Russian Association Endocrinologists, for Osteoporosis, Rheumatologists Russia, Traumatologists and Orthopedists Menopause Gerontologists Geriatrics is presented. The recommendations were from perspective evidence-based medicine, in accordance with requirements compiling Ministry Health Russia published 2019. significant place given to screening primary adults, differential diagnosis other metabolic...
<b><i>Introduction:</i></b> Primary hyperparathyroidism (PHPT) is rare and usually symptomatic in children. There no approved medication to lower serum calcium levels this patient group. Denosumab used adult patients with osteoporosis hyperparathyroidism. To our knowledge, only 1 case of denosumab treatment a child severe PHPT has been reported date. <b><i>Case Presentation:</i></b> A 16-year-old female was referred clinic symptoms including...
BACKGROUND: MEN-1 is a rare autosomal dominant disease caused by mutations in MEN1 gene encoding the menin protein. This syndrome characterized occurrence of parathyroid tumors, gastroenteropancreatic neuroendocrine pituitary adenomas, as well other endocrine and non-endocrine tumors. If patient with phenotype carry no gene, condition considers phenocopy (phMEN1). The possible cause this changes could be epigenetic regulation, particularly microRNA expression that might affect signaling...
AIM: To analyze the diagnostic performance of bilateral inferior petrosal sinus sampling (BIPSS) with desmopressin as a stimulation agent and prolactin measurements to control catheter position or without ACTH/prolactin normalized ratio calculation in differential diagnosis ACTH-dependent endogenous hypercortisolism, diagnostics ectopic ACTH-syndrome (EAS) visualization. MATERIALS AND METHODS: A single-center study retrospective analysis data was carried out. The included patients...
Background There are very few cases of co-occurring pituitary adenoma (PA) and pheochromocytomas (PCC)/paragangliomas caused by MAX mutations. No familial PA in patients with mutations have been described to date. Case Presentation We describe a 38-year-old female patient, presenting clinical biochemical features acromegaly PCC the left adrenal gland. Whole-exome sequencing was performed [NextSeq550 (Illumina, San Diego, CA, USA)] identifying nonsense mutation gene (NM_002382)...
Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study aims build a registry database of Russian patients with who were referred for hospital treatment order conduct initial analysis clinical presentations management. The Italian model was taken be able...
Представлено краткое изложение клинических рекомендаций по диагностике и лечению остеопороза, разработанных членами Российской ассоциации эндокринологов при участии членов остеопорозу (ревматологов, травматологов, терапевтов, гинекологов-эндокринологов). Рекомендации разработаны с позиций доказательной медицины, в соответствии требованиями к составлению Минздрава России, опубликованными 2016 г. Значительное место изложении отведено остеопороза у взрослых, дифференциальной другими...
When primary hyperparathyroidism (PHPT) is diagnosed in a young patient the absence of other clinical manifestations differential diagnosis between sporadic form PHPT and as first manifestation one hereditary syndromes may be challenging. Diagnosis or determines extent surgical intervention, strategy for further observation treatment, need examination treatment first-degree relatives. Aim study — to determine genetic characteristics with at age (<40 years old) clinically familial isolated...
Primary hyperparathyroidism (PHPT) is well studied in elderly patients. Studies of PHPT characteristics children, adolescents, and young adults are rare. In some these studies, investigators have compared clinical laboratory between patients revealed several differences. An early onset may indicate familial syndromes associated with PHPT. These include: multiple endocrine neoplasia syndrome type 1, 2A, 4, hyperparathyroidism-jaw tumor syndrome, hypocalciuric hypercalcemia, isolated...
Primary hyperparathyroidism (PHPT) is sporadic in the majority of cases. Hereditary forms PHPT are rarer, however, they particular interest because allow a deeper understanding pathogenesis parathyroid neoplasia. include multiple endocrine neoplasia type 1 (MEN-1), 2A (MEN-2A), 4 (MEN-4), hyperparathyroidism-jaw tumour syndrome (HPT-JT), variants familial hypocalciuric hypercalcemia (FHH) and isolated (FIHP). Mutations following genes cause development MEN-1, MEN-2A, MEN4, HPT-JT: MEN1, RET,...
Osteoporosis medications are divided into two groups: those inhibiting bone resorption and formation (bisphosphonates denosumab), stimulating i.e. having an anabolic effect. The latter include teriparatide, parathyroid hormone 1-84 abaloparatide, all of which stimulate as well formation, limits their effect.
 discovery sclerostin – the key inhibitor has led to development concept that inhibition this protein could formation. Romosozumab is a human monoclonal antibody binds enables...
Changes in the expression of non-coding ribonucleic acids (ncRNAs) takes part formation various tumors. Multiple endocrine neoplasia syndrome type 1 (MEN1) is a rare autosomal dominant disease caused by mutations MEN1 gene encoding Menin protein. Syndrome characterized occurrence parathyroid tumors, gastroenteropancreatic neuroendocrine pituitary adenoma, as well other and non-endocrine The mechanisms for MEN1-related tumors due to are not . In absence patients with phenotypically similar...