A5006960127- Bone health and osteoporosis research
- Hip and Femur Fractures
- Healthcare Systems and Public Health
- Bone Metabolism and Diseases
- Medical and Biological Sciences
- Bone health and treatments
- Vitamin D Research Studies
- Rheumatoid Arthritis Research and Therapies
- Bone fractures and treatments
- Biomarkers in Disease Mechanisms
- Human Health and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Chronic Disease Management Strategies
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Inflammatory mediators and NSAID effects
- Vitamin C and Antioxidants Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hip disorders and treatments
- Healthcare cost, quality, practices
- Healthcare Policy and Management
- Genomics and Rare Diseases
North-Western State Medical University named after I.I. Mechnikov
2015-2024
Ministry of Health of the Russian Federation
2015-2019
Ural State Medical University
2005-2018
Ural Branch of the Russian Academy of Sciences
2013
Regional Children's Hospital No1
1996-2007
Regional Children's Clinical Hospital No. 1
2001
Amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions that develops when proteolytic fragments serum amyloid protein (SAA) are deposited in tissues as fibrils. deposition the kidney causes progressive deterioration renal function. Eprodisate member new class compounds designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans thereby inhibit polymerization fibrils tissues.We performed multicenter, randomized, double-blind,...
Screening using the Fracture Risk Assessment Tool (FRAX) is recommended in all postmenopausal woman and mеn over 50 (A1) order to identify individuals with high probability of fractures. It diagnose osteoporosis start treatment patients fragility fracture large bones skeleton and/or individual major fractures detected decrease bone mineral density (BMD) up –2.5 T-score as assessed by DXA femoral neck lumbar vertebrae (A1). Patients back pain, lifetime height loss 4 cm or 2 since a previous...
Due to continuous aging of population and increase in the number elderly people, osteoporosis became socially significant disease leading disability, increasing mortality thereby putting an additional burden on public healthcare system. Screening identify groups with a high probability fracture is recommended using FRAX ® Tool for all postmenopausal women men over 50 years old (А1). In presense major pathological fractures (hip, spine, multiple fractures) it diagnose prescribe treatment...
The authors performed an analysis of published stadies devoted to osteoporosis situation in Russian Federation including epidemiological, social, medical and economical aspects this pathology. demonstrated that is reported every third woman forth man 50 years old older. Seven vertebra fractures happen minute one fracture proximal femur — 5 minutes Russia. An overall number all key osteoporotic will increase from 590 thousand up 730 cases by the year 2035. Osteoporosis financially demanding...
Retrospective and prospective population-based survey in a region of the Republic Kazakhstan determined incidence fractures at hip, proximal humerus distal forearm. The hip fracture rates were used to create FRAX® model enhance risk assessment Kazakhstan.This paper describes epidemiology osteoporotic that was develop country specific tool for prediction.We carried out retrospective Taldykorgan representing approximately 1% country's population. Hip, forearm identified retrospectively 2015...
This consensus was prepared by a group of experts from various specialties in the interests improving quality specialized medical care for elderly and old age patients with hip fractures, which are almost always result osteoporosis an increased risk falls. Difficulties treatment this category due to both severity injury itself comorbidity, is accompanied high mortality extremely low life survivors. Effective management such possible only joint involvement doctors nurses surgical internal...
This article presents a case report and review of sources about hypophosphatemic osteomalacia, rare adverse effect chronic hepatitis B treatment with tenofovir disoproxil fumarate. Hypophosphatemic osteomalacia is caused by partial or complete Fanconi syndrome reduced renal function due to acute damage the proximal tubules. describes manifestations such as multiple skeletal fractures, including rib vertebral left acetabular sacral bone joint pain, signs neuropathy, severe muscle weakness....
INTRODUCTION. The development of an interdisciplinary consensus on the care elderly and patients with proximal femoral fractures is urgent problem modern medicine. provisions this Consensus will help to establish effective interaction between physicians different specialties basis their better understanding, which contribute improvement specialized medical care, saving lives reducing disability hip through. MAIN CONSENSUS CONTENT. Hip through are one most frequent severe complications...
Preliminary results of interregional program “Social and economic consequences rheumatic diseases” diagnostic stage are presented.Objective. Clinical examination persons with joint pathology revealed during screening to determine the diagnosis.Material methods. A group persons, who had complaints at or previous year, was randomly formed according screening. Thorough uniform clinical participation a qualified rheumatologist aimed precise determination character performed in all cases. During...
Objective. Amyloid A protein quantification in fat tissue is a new immunochemical method for detecting AA amyloidosis, rare but serious disease. The objective was to assess diagnostic performance clinical amyloidosis.Methods. Abdominal subcutaneous of patients with amyloidosis studied at the start an international trial eprodisate (NC-503; 1,3-propanedisulfonate; Kiacta™), antiamyloid compound. All had renal findings, i.e. proteinuria (≥1 g/day) or reduced creatinine clearance (20 – 60...
Fracture probabilities derived from the surrogate FRAX model for Armenia were compared to those based on regional estimates of incidence hip fracture. Disparities between and authentic models indicate importance developing country-specific models. Despite large differences models, in rank order fracture minimal. has relied a epidemiology Romania. This paper describes fragility fractures used create an Armenia-specific with aim comparing this new model. We carried out population-based study...