A5086054387- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Electrolyte and hormonal disorders
- Endometriosis Research and Treatment
- Neuroendocrine Tumor Research Advances
- Inflammation biomarkers and pathways
- Moyamoya disease diagnosis and treatment
- Parathyroid Disorders and Treatments
- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Vitamin D Research Studies
- Neuroblastoma Research and Treatments
- Meningioma and schwannoma management
- Bone health and treatments
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Porphyrin Metabolism and Disorders
- Bone health and osteoporosis research
- Connective tissue disorders research
- Academic Publishing and Open Access
- Angiogenesis and VEGF in Cancer
Endocrinology Research Center
2017-2024
Objective To evaluate the response of bone to chronic long-term growth hormone (GH) and insulin-like factor-1 (IGF1) excess by measuring expression selected mRNA microRNA (miR) in tissue samples patients with active acromegaly. Design Case–control study. Methods Bone were obtained during transsphenoidal adenomectomy from sphenoid (sella turcica) 14 clinically biochemically confirmed acromegaly 10 non-functioning pituitary adenoma (NFPA) matched sex age. Expression genes involved regulation...
We recommend acromegaly to be ruled in all patients with characteristic changes appearance (A3). In without appearance, we rule out acromegaly, if several clinical signs suspicious for are present (B3). pituitary adenoma prolactin-secreting adenomas (C4). For laboratory confirmation of measure serum insulin-like growth factor-1 (IGF-1, somatomedin C) level obvious and/or a moderate increase IGF-1 levels (IGF-1 index less than 1.3), assess the response somatotropic hormone (GH) hyperglycemia...
BACKGROUND: The registry is the main source of information about patients with acromegaly for assessing quality medical care, effectiveness treatment, determining compliance real clinical practice existing standards and patient management protocols. AIMS: To evaluate epidemiological, demographic characteristics in Russian Federation treatment modalities. MATERIALS AND METHODS: object study was database united pituitary tumors specific analysis only. We analyzed data 4114 stored on online...
We do not recommend population screening for diabetes insipidus (DI) (B3). to perform diagnostic testing central (CDI) in patients who underwent neurosurgery, after skull and brain trauma, subarchnoid hemorrhage excluding thirst impairment during all stages of assessment (С3). DI cases persistent hypotonic polyuria: excretion more than 3 L. or 40 mL/kg urine daily; osmolality less 300 mOsm/kg urinary specific gravity 1004 g/L samples Zimnitsky test (В3). After polyuria is confirmed, we the...
This article considers the role of calcium and vitamin D in body functions, with focus on skeletal system. We reviewed results studies supplementation worldwide Russia. According to these studies, there is insufficient dietary intake nutrients, irrespective geographical, ethnic features physiological conditions. also data safety supplementations for urinary cardiovascular systems, regimens doses deficiency treatment various age groups. The contains calcium, combined medications, available...
Abstract Context Excessive production of growth hormone causes marked multiorgan changes in patients with acromegaly, which may involve epigenetic mechanisms. Objective To evaluate differences circulating microRNAs (miRNAs) associated chronic overproduction adults. Design and Setting A cross-sectional case-control study was conducted at a tertiary medical center. Participants We enrolled 12 consecutive acromegaly along age- sex-matched controls the discovery phase then extended this cohort...
BACKGROUND: microRNA is a class of small non-coding RNA molecules involved in posttranscriptional regulation gene expression. MicroRNAs are detectable blood stable concentrations, which makes them promising biomarkers for various diseases. AIM: to assess plasma expression patients with active acromegaly compared healthy controls. MATERIAL AND METHODS: single-center, case-control study: assessment Fasting samples were drawn and centrifuged at +5С temperature 3000 rpm 20 minutes, then...
Adult growth hormone (GH) deficiency (AGHD) is a condition characterized by alterations in body composition, lipid and carbohydrate metabolism, bone mineral density poor quality of life; however, clinical presentations AGHD are mostly non-specific. Untreated associated with increased cardiovascular morbidity mortality. Stimulation tests used for the diagnosis: insulin tolerance test, glucagon stimulation growth-hormone releasing arginine test. Moreover, 2017 FDA approved use macimorelin...
BACKGROUND : For the last decades microRNAs (miR) have proven themselves as novel biomarkers for various types of diseases. Identification specific circulating microRNA panel that differ patient with Cushing’s disease (CD) and ectopic ACTH syndrome (EAS) could improve diagnostic procedure. AIM to evaluate differences in miR levels plasma samples drained from inferior petrosal sinuses patients CD EAS. MATERIALS AND METHODS single-center, case-control study: we enrolled 24 ACTH-dependent (CS)...
MicroRNA presents small (19–25 nucleotides long) non-coding RNA molecules which regulate gene expression on post-transcriptional level. Numerous studies revealed microRNA’s important role in physiological processes. Moreover, its aberrant has been described many pathological conditions including pituitary tumors. Pituitary adenomas are benign intracranial tumors with various clinical presentations depending the type of hormone secretion. Prediction adenoma aggressive level and treatment...
BACKGROUND: Pituitary adenomas are the third most common intracranial neoplasm. Clinical significance is determined by nature of growth and hormonal activity, leading to disruption various parts metabolism. Medical registries a valuable tool for assessing clinical epidemiological parameters obtaining data on real-life practice. AIM: To analyze characteristics four pituitary disorders in Russian Hypothalamic Tumor Registry (OGGO): acromegaly, Cushing’s disease, prolactin-secreting...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Acromegaly is a rare neuroendocrine disease caused by excessive production of growth hormone (GH), which acts as trigger for cartilage tissue destruction leading to joint damage. Patients with acromegaly, especially in the active stage, often complain pain various locations. Joint can be one first symptoms disease, intensity worsens without proper treatment. Increased GH leads configuration changes joints, turn destructive processes typical degenerative diseases such osteoarthritis. Despite...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Pathogenesis of secondary hyperparathyroidism is based on D-hormone deprivation, leading to bone remodeling impairment, increase in FGF-23, PTH levels, changes blood calcium and phosphorus levels. Taken together with alteration calcium-sensing receptor (CaSR) sensitivity, these result structure cardiovascular complications. CaSR agonists are one the most important medications for treatment dialysis patients. Until recently, there was only agonist proven effectiveness – cinacalcet, which...
We present three clinical cases of successful osteoporosis treatment with denosumab in patients different courses osteoporosis: postmenopausal bisphosphonates ineffectiveness, mixed etiology patient on thyroid stimulating hormone suppression and aromatase inhibitor therapy a case male caused by primary hyperparathyroidism. Mechanism action is from bisphosphonates: prevents osteoclast differentiation binding to receptor activator nuclear factor kappa-B ligand (RANKL) thus suppressing bone...
Multiple endocrine neoplasia syndrome type 1 (MEN1, Wermer's syndrome) is a group of heterogeneous inherited diseases, with its pathogenesis related to hyperplasia or neoplasms several glands. This characterized by autosomal dominant mode inheritance, high penetrance and similar prevalence among males females. Prevalence MEN1 estimated be 1:100,000 the population. An interesting feature presented clinical case relapse transformation pituitary tumor from prolactin-secreting into mixed one,...
We do not recommend population screening for diabetes insipidus (DI) (B3). to perform diagnostic testing central (CDI) in patients who underwent neurosurgery, after skull and brain trauma, subarchnoid hemorrhage excluding thirst impairment during all stages of assessment (С3). DI cases persistent hypotonic polyuria: excretion more than 3 L. or 40 mL/kg urine daily; osmolality less 300 mOsm/kg urinary specific gravity 1004 g/L samples Zimnitsky test (В3). After polyuria is confirmed, we the...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
We describe a unique case of diagnosing salt-wasting congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency in 32-year-old male patient. Before establishing the diagnosis, main patient complaint was infertility. In childhood, suffered from developmental delay, often illness, overconsumption salt, and vomiting; he stopped growing at age 12 years. adolescent period, his physical condition improved. Later, got married, but infertile. Plasma steroid profiling gas...
BACKGROUND . Neurosurgery is the most effective treatment for acromegaly. As of patients present with macroadenomas, surgical not always successful, even expert level a neurosurgeon. Assessment postoperative remission rates in acromegaly preoperative predictors efficacy an urgent task modern research. AIM: To assess short-term and long-term after endoscopic transnasal adenomectomy tertiary medical center effectiveness. MATERIALS AND METHODS : A single-center, prospective, uncontrolled study...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)