A5090095902- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Bone health and treatments
- Pancreatic function and diabetes
- Electrolyte and hormonal disorders
- Lung Cancer Research Studies
- Renal Transplantation Outcomes and Treatments
- Diabetes Management and Research
- Single-cell and spatial transcriptomics
- Congenital heart defects research
- Molecular Biology Techniques and Applications
- Adrenal Hormones and Disorders
- Advanced Fluorescence Microscopy Techniques
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Neurological and metabolic disorders
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Oral and gingival health research
- Fatty Acid Research and Health
Endocrinology Research Center
2022-2025
Kuban State Medical University
2020
Current dissociation methods for solid tissues in scRNA-seq studies do not guarantee intact single-cell isolation, especially sensitive and complex human endocrine tissues. Most rely on enzymatic of fresh samples or nuclei isolation from frozen samples. Dissociating whole cells fresh-frozen samples, commonly collected by biobanks, remains a challenge. Here, we utilized the acetic-methanol approach (ACME) to capture transcriptional profiles individual tissue This method combines acetic...
Parathyroid carcinoma (PC) is one of the rarest malignant neoplasms human endocrine system, with a prevalence approximately 0.005% all oncological diseases. Despite its indolent course, PC generally relapses in about 40%-60% cases. The severity disease usually determined by uncontrolled life-threatening hypercalcemia. Currently, there are no reliable criteria for preoperative diagnosis PC; moreover, topical and morphologic examination remain challenges. Surgery remains gold standard...
Intrahepatic cholangiocarcinoma is a highly malignant tumor with poor prognosis. Radical surgical resection remains the “gold standard” for improving patient outcomes; however, only minority of patients qualify this approach. primarily classified into two major histologic types: small and large ductal cholangiocarcinomas. Nevertheless, rare subtypes unique diagnostic prognostic characteristics are increasingly reported. These often exhibit features such as slow growth, architecture...
Sagliker syndrome (SS) is an extremely rare disorder that manifests in patients with advanced chronic kidney disease (CKD) undergoing programmed hemodialysis as a renal replacement therapy. Treatment of secondary hyperparathyroidism (SHPT) these still challenging. The main clinical manifestations SS include craniofacial and fingertip deformities, dental anomalies, gingival hyperplasia, short stature, hearing loss, neurological psychiatric impairment. etiology pathogenesis SHPT require...
Until recently no major epidemiological research of primary hyperparathyroidism (PHPT) has been conducted in the Russian Federation, this led to creation online registry. The objective study is estimate clinical and biochemical profile, classical non-classical complications, surgical intervention medical therapy patients with different forms PHPT Federation. cross-sectional, observational, continuous was at Endocrinology Research Centre (Moscow). present explored retrospective data from 6003...
Simultaneous pancreas-kidney transplantation (SPKT) can improve long-term patient survival and restore endogenous insulin secretion in recipients with type 1 diabetes (T1D). There are currently few data on glucose fluctuations assessed by continuous monitoring (CGM) after SPKT. Aim: to evaluate CGM-derived time range (TIR) variability (GV) patients T1D functioning pancreatic grafts Fifty-four CGM recordings from 43 patients, 15 men 28 women, aged 34 (31; 39) years were analyzed. Time since...
Abstract Current scRNA-seq studies of solid tissues mostly rely on enzymatic dissociation fresh samples or the fallback nuclei isolation from frozen partially fixed samples. However, due to complex tissue organization cell fragility, it could be challenging apply these approaches sensitive endocrine tissues. That is, dissociating intact cells such problematic fresh-frozen routinely collected by biobanks remains challenging. In this study, we adapted acetic-methanol method – ACME High Salt...
Pseudohypoparathyroidism (PHP) is a heterogeneous orphan disease characterized by multihormonal resistance and several phenotypic features. In some cases, PHP caused mutation in the GNAS that encodes alpha subunit of G protein, one key transmitters intracellular signals. A correlation between genotype phenotype patients with mutations has not yet been described. This often makes diagnosis, drug prescription, timely diagnosis difficult. Information about functioning impact specific on...
Diabetic nephropathy (DN) is a specific kidney involvement in diabetes mellitus (DM), caused by hemodynamic and metabolic factors. In the kidneys takes place an important step metabolism of vitamin D — 1α-hydroxylation, which results formation its biologically active form. Reduced number functioning nephrons DN leads to impaired metabolism, contributing development complications. this review, we have focused detail on both normal features chronic disease (CKD). most common cause CKD and, as...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Parathyroid carcinoma (PC) is extremely rare in children and adolescent. PC more often sporadic, but also it could be associated with germline mutations. The clinical features of primary hyperparathyroidism (PHPT) are nonspecific adolescent, which delays the diagnosis for years. This case a pediatric patient, caused by heterozygous pathogenic variant exon 1 CDC73 gene (c.70 G > T, p. Glu24Ter) first to reported Russia. Due rarity parathyroid malignancy, this endocrine neoplasm remains...
BACKGROUND . Chronic hypoparathyroidism (HypoPT) is a relatively rare endocrine disorder. Adequate control of the disease requires prescription lifelong multicomponent therapy. Lack sustained compensation HypoPT associated with development both early and delayed complications, including functional structural renal pathology, cataracts, cerebral calcification, cardiac rhythm and/or conduction disorders, others. AIM To study associations clinical, laboratory instrumental parameters, as well...
BACKGROUND . Chronic hypoparathyroidism (HypoPT) is a rare endocrine disorder that requires lifelong multi-component therapy. The goal of HypoPT treatment to reach the target values main indicators calcium-phosphorus metab olism, first all — calciemia, as well prevent acute and delayed complications, including pathology kidneys, eyes, brain other organs. One ways improve quality medical care, determine optimal clinical therapeutic management strategies, find prognostic markers for analyze...
Multiple endocrine neoplasia syndrome type 4 (MEN-4) is a rare autosomal dominant disease caused by mutation in the CDKN1B gene encoding cell cycle regulator p27. Currently, small number of clinical cases patients with this pathology are known. Patterns genotype-phenotype correlations mutations remains controversial and requires additional clarification. MEN-4 affects same organs as MEN-1, however, age manifestation course may differ. We present case patient new frame shift PHPT multiple...
This article presents a review of available information on asprosin — hormone white adipose tissue discovered in 2016. The history its discovery, as well action mechanisms and main targets are examined. Changes the plasma level under some pathological conditions analysed. importance studying is determined by functions: regulates physiological processes during fasting plays an important role development metabolic disorders, such insulin resistance. There relatively few studies concerned with...
Cardiovascular diseases (CVD) and metabolic disorders (MD) have retained leading positions in the structure of morbidity mortality for many years. Primary hyperparathyroidism (PHPT) is also associated with a greater incidence CVD MD. The aim present study was to describe prevalence MD hospitalized patients PHPT search possible associations between these pathologies.838 verified were included study. studied cohort divided into 2 groups according their age at time admission: aged 18 49 years...
Deterministic effects of medical exposure to ionising radiation can be associated with both the effectiveness treatment and adverse drug reactions it. The latter may drastically deteriorate quality life a patient after radionuclide therapy. In addition, regulations Russian Federation require indicating effective dose as measure damage (risk), but presence deterministic effect in individual organs tissues complicates monitoring recording doses. aim study was investigate radiopharmaceuticals...
At the present time, a simultaneous pancreas-kidney transplantation (SPKT) is an effective method of treatment for patients on renal replacement therapy by hemodialysis program in outcome terminal stage diabetic nephropathy. This solves several problems: it reduces severity intoxication syndrome, contributes to achievement euglycemia most cases, which certainly allows slow progression micro- and macrovascular complications diabetes. Despite positive effect euglycaemia kidney function...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)