A5038129187- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Vitamin D Research Studies
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Bone health and osteoporosis research
- Bone health and treatments
- Healthcare Systems and Public Health
- Genetic Syndromes and Imprinting
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Magnesium in Health and Disease
- Cancer Immunotherapy and Biomarkers
- Human Health and Disease
- Adrenal and Paraganglionic Tumors
- Electrolyte and hormonal disorders
- Diabetes Management and Research
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
Endocrinology Research Center
2020-2024
The aim To study the association of demographic, clinical, and laboratory factors use glucose-lowering drugs anti-coronavirus disease (COVID-19) vaccination with COVID-19-related case fatality rate (CFR) in diabetes mellitus (DM) patients. Methods This is a nationwide observational cohort based on data from National Diabetes Register (NDR) that database containing online clinical information about population DM. outcomes (death or recovery) for COVID-19 were registered 235,248 patients DM...
Hypercalcemic crisis is a severe but rare complication of primary hyperparathyroidism (PHPT), and data on denosumab treatment patients with this disease still very limited. The aim paper to investigate the hypocalcemic effect in PHPT hypercalcemia when surgery should be delayed or impossible for some reasons. We performed retrospective study 10 patients. analysis included use biochemical markers calcium-phosphorus metabolism, which were followed after administration 60 mg denosumab. trend...
Until recently no major epidemiological research of primary hyperparathyroidism (PHPT) has been conducted in the Russian Federation, this led to creation online registry. The objective study is estimate clinical and biochemical profile, classical non-classical complications, surgical intervention medical therapy patients with different forms PHPT Federation. cross-sectional, observational, continuous was at Endocrinology Research Centre (Moscow). present explored retrospective data from 6003...
BACKGROUND: The coronavirus pandemic has had an extremely negative impact on the patients with diabetes mellitus (DM both in terms of a more severe course COVID -19 and increased risk death. AIM: Analysis factors for death due to DM type 1 2 (DM1 DM2). MATERIALS AND METHODS : Retrospective analysis database national register (NDR), which included COVID-19 reported virus infection outcome (recovery/or death) 15 712 DM1 322 279 DM2 during 2-year follow-up period (01/02/2020 03/04/2022)...
BACKGROUND : Primary hyperparathyroidism (PHPT) is a endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH) from gland tumors. Parathyroidectomy (PTE) the main treatment for PHPT, but it can lead to hypocalcemia in up 46% cases. Hypocalcemia associated with seizures and life-threatening cardiac arrhythmias, vitamin D deficiency exacerbate PHPT severity contribute «hungry bones syndrome,» resulting severe persistent postoperative hypocalcemia. AIM To evaluate...
Chronic hypoparathyroidism is a relatively rare disease associated with multicomponent medical therapy and various complications. The analysis of large databases patients chronic necessary tool to enhance quality care, as well determine the optimal clinical therapeutic approaches, prognostic markers disease.of this study estimate biochemical profile, long-term complications, control postsurgical non-surgical hypoparathyroidism.the cross-sectional, observational, continuous was based on...
To compare the serum miRNA expression profiles between patients with benign and malignant parathyroid tumours.Despite recent advances in molecular biology, a histological tissue biopsy is still method of choice used to diagnose most cancers. The preoperative cytology not an applicable for diagnosis cancer (PC); therefore, huge interest exists terms finding alternative methodologies seek specific biomarkers.A retrospective cross-sectional study.Serum samples PC (n = 13) adenoma (PA) 11), age...
BACKGROUND: Overweight and obesity have a significant impact on the course results of treatment many diseases, including cancer. One modern types antitumor therapy is immune checkpoint inhibitors. Taking into account high effectiveness inhibitors for various tumors, it seems interesting to study initial anthropometric data patients assess possible influence nutritional status development endocrine immune-mediated adverse events. AIM: To compare groups with different starting body mass index...
Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination scope surgical intervention. Nowadays, specific diagnostic markers differentiation PC and benign tumors are unknown, less than half patients with undergo necessary en bloc surgery. The aim this study was to develop instrument preoperative PC. A multi-center retrospective included 242 primary hyperparathyroidism: 50 PC, 30 аtypical adenoma (AA), 162 glands. Patients AA had higher levels PTH, ionized...
Components of metabolic syndrome can be observed in patients with primary hyperparathyroidism (PHPT). The link between these disorders remains unclear due to the lack relevant experimental models and heterogeneity examined groups. effect surgery on abnormalities is also controversial. We conducted a comprehensive assessment parameters young PHPT.One-center prospective comparative study was carried out. participants underwent complex biochemical hormonal examination, hyperinsulinemic...
In the midst of continuing coronavirus infection (COVID-19) there has been an increase in incidence various autoimmune pathologies. Particular attention to potential relationship between and diseases is attracted by positive therapeutic effect treatment severe forms COVID-19 with drugs used rheumatologically diseases.The results study should be starting point for understanding mechanisms possible breakdown immunological tolerance development thyroid diseases. AIM : To assess risks developing...
<h3></h3> Первичный гиперпаратиреоз (ПГПТ) ассоциирован с большей частотой ряда метаболических и сердечно-сосудистых заболеваний. Оценка распространенности этих нарушений необходима для определения тактики ведения пациентов ПГПТ. На сегодняшний день такие эпидемиологические данные в мире Российской Федерации лимитированы. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Оценить распространенность структуру сердечно-сосудистой патологии, углеводного, липидного пуринового обмена у <h3>МАТЕРИАЛ И МЕТОДЫ</h3>...
BACKGROUND : Primary hyperparathyroidism (PHPT), one of the most common endocrine pathologies, is associated with a higher incidence cardiovascular diseases, in particular, those caused by endothelial dysfunction. Evaluation dysfunction patients PHPT will predict development pathology and determine optimal tactics for management. AIM To evaluate concentration soluble endoglin photoplethysmographic parameters as potential markers PHPT. MATERIALS AND METHODS A single-center interventional...
BACKGROUND : Currently, there are no data on the prevalence and incidence of insulinoma in Russia. The published world epidemiology tumor largely variable. Thus, it is important to systematize information world, including AIM: To assess world. TASKS Analysis literature data. database Endocrinology Research Centre. MATERIALS AND METHODS implement Task 1, an analysis foreign Russian articles PubMed eLIBRARY.RU databases from 1927 was carried out until June 2023, following keywords:...
Background. Chronic kidney disease (CKD) is a socially significant pathology associated with an increased risk of mortality and progression to terminal stages, requiring expensive treatment renal replacement therapy, which determines the priority preventive strategies, especially in patients diabetes mellitus (DM), who are at high Kidney's injury.
 Aim. To analyze predictors decrease glomerular filtration rate (GFR) less than 60 ml/min/1.73 m2 develop applied CKD prediction calculator...
Background: there are no specific markers of the parathyroid carcinoma (PC) therefore, development algorithms for identifying high-risk patients is an urgent task. Aims: to determine clinical and laboratory predictors PC identify factors a poor prognosis. Materials methods: A multicenter retrospective study included 242 with primary hyperparathyroidism (PHPT) who were divided into groups: 162 adenomas, 30 аtypical adenomas (АА) 50 PC. Data collection analysis was carried out from 2017 2020....
Aim.To study an activity of the Renin-Angiotensin-Aldosterone System (RAAS) components in patients with primary hyperparathyroidism (PHPT) before and after parathyroidectomy (PTE). Materials methods.A comparative PHPT control group. The first stage included 56 (group 1) on third day PTE. second was carried out 27 remission 2). All healthy volunteers were tested for main parameters phosphorus-calcium metabolism RAAS (plasma renin PRA, serum aldosterone, angiotensin II AT II). Results.Patients...
BACKGRAUND : Currently high frequency of thyroid or parathyroid surgery is associated with significant increased incidence hypoparathyroidism. Evaluation the epidemiological and clinical features chronic hypoparathyroidism necessary to predict social-significant complications improve quality medical care. AIMS To estimate demographic features, different regimens efficacy conventional therapy in patients postsurgical nonsurgical MATERIALS AND METHODS The cross-sectional, observational,...
BACKGROUND: Chronic hypoparathyroidism is a relatively rare disease, which usually treated active forms of vitamin D and oral calcium supplements. Supplementation with native can be useful both for achieving «non-skeletal» effects more stable serum profile. AIM: The aim this study was to estimate the daily 24-hour urine levels depending on different 25(OH) values in patients chronic treatment MATERIALS AND METHODS : Forty were involved study. All divided two groups, matched sex age,...
BACKGROUND : Multiple endocrine neoplasia type 1 (MEN1) — is a rare syndrome with an autosomal dominant inheritance pattern caused by mutation in the tumor suppressor gene (MEN1). Parathyroid involvement most common MEN1 manifestation resulting primary hyperparathyroidism (mPHPT). Data on prevalence and structure of bone disease mPHPT compared to sporadic one (sPHPT) are often incomplete contradictory. AIM The purpose this study was compare severity between sPHPT. MATERIALS AND METHODS A...
To develop the mathematical model with high sensitivity and specificity to assess malignant potential of adrenal cortical tumors, which can be used diagnose adrenocortical carcinoma (ACC) in adults.
Differential diagnosis of atypical parathyroid tumors (APT) and carcinomas (PC) is important in determining further management prognosis. Morphologic sometimes difficult, which case it supplemented by immunohistochemical (IHC) examination.
BACKGROUND . Chronic hypoparathyroidism (HypoPT) is a relatively rare endocrine disorder. Adequate control of the disease requires prescription lifelong multicomponent therapy. Lack sustained compensation HypoPT associated with development both early and delayed complications, including functional structural renal pathology, cataracts, cerebral calcification, cardiac rhythm and/or conduction disorders, others. AIM To study associations clinical, laboratory instrumental parameters, as well...
The rarity and variability of MEN1-related primary hyperparathyroidism (mPHPT) has led to contradictory data regarding the bone phenotype in this patient population.