Sagliker syndrome (SS) is an extremely rare disorder that manifests in patients with advanced chronic kidney disease (CKD) undergoing programmed hemodialysis as a renal replacement therapy. Treatment of secondary hyperparathyroidism (SHPT) these still challenging. The main clinical manifestations SS include craniofacial and fingertip deformities, dental anomalies, gingival hyperplasia, short stature, hearing loss, neurological psychiatric impairment. etiology pathogenesis SHPT require...

A 59-year-old male presented with an accidental thyroid mass in 2022. Ultrasound and CT scan showed a nodule 5.2 × 4.9 2.8 cm (EU-TIRADS 4) the right lobe of gland. Taking into account results fine needle aspiration biopsy (Bethesda V), intrathyroid localization, absence clinical symptoms, malignant tumor gland was suspected. The patient underwent total thyroidectomy using fluorescence angiography indocyanine green, two pairs intact parathyroid glands were visualized typical localization....

The obesity epidemic has led to the growing number of bariatric operations and expansion indications for this operation as most effective method treatment, that’s why endocrinologists are increasingly faced challenge late complications, including postbariatric hypoglycemia. Postbariatric hypoglycemia is a rare but severe metabolic disorder that occurs months or years after upper gastrointestinal surgery. can be accompanied by clinical symptoms lead disability decreasing life’s quality. It...

Parathyroid cancer (PС) is a rare malignant neoplasm of the endocrine system, characterized by severe course due to development life-threatening hypercalcemia. Despite relatively high survival rate, recurrence occurs about half time. The aggressive PС associated with both local spread process and distant metastasis. With exception isolated cases, cytotoxic chemo- radiotherapy are inefficacious, treatment protocols have not been developed. Therefore only effective way surgical removal...

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

Differential diagnosis of atypical parathyroid tumors (APT) and carcinomas (PC) is important in determining further management prognosis. Morphologic sometimes difficult, which case it supplemented by immunohistochemical (IHC) examination.

Parathyroid carcinoma (PC) is extremely rare in children and adolescent. PC more often sporadic, but also it could be associated with germline mutations. The clinical features of primary hyperparathyroidism (PHPT) are nonspecific adolescent, which delays the diagnosis for years. This case a pediatric patient, caused by heterozygous pathogenic variant exon 1 CDC73 gene (c.70 G > T, p. Glu24Ter) first to reported Russia. Due rarity parathyroid malignancy, this endocrine neoplasm remains...

Background. Currently, there is no consensus on postoperative risk stratification for parathyroid cancer (PC). The factors of disease progression are crucial choosing the optimal treatment strategy, including adjuvant methods and patient,s follow-up. Aim. Identifying predictors PC recurrence Materials methods. We performed a retrospective observational study 85 patients with verified divided into remission (n=61) (n=19) groups after primary surgical period 2004–2023. analyzed parameters...

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by autonomous secretion of parathyroid hormone altered glands. In most cases PHPT sporadic disease, 5-10% observations are genetically determined syndromal and non-syndromal forms. Studies families with hereditary forms have led to the discovery key oncosuppressor genes proto-oncogenes whose somatic mutations underlie development many tumors. Another interest in pathogenesis primary studying mechanisms epigenetic...

BACKGROUND : MEN1-related hyperparathyroidism (mPHPT) is a rare inherited form of primary (PHPT) that caused by germline mutation in the MEN1 gene. The available data on bone phenotypes mPHPT are scarce and contradictory due to orphan nature disease, under-recognition disease limited use genetic screening, heterogeneity samples evaluated. AIM To evaluate phenotypic features verified MEN1-associated hyperparathyroidism, including associated complications, according from Russian register...

Multiple endocrine neoplasia syndrome type 1 (MEN-1) is an inherited disorder associated with mutations in the MEN1 gene and characterized by «classic triad»: involvement of parathyroid gland, pancreatic islet cells anterior pituitary. The penetrance primary hyperparathyroidism (PHPT) MEN-1 reaches 90-100% age. Primary polyglandular lesions, tumors do not always develop synchronously, leading to a high incidence disease recurrence after surgery. In MEN-1-associated PHPT, hyperplasia most...

BACKGROUND: The glucagon test (GT) is a promising alternative to the insulin hypoglycemia (IHT) in diagnosis of secondary adrenal insufficiency (SAI). AIM: To study feasibility using GT patients after craniospinal irradiation and determine cut-off value rule out SAI. METHODS: A total 28 (14 males 14 females) with median age 19 years (17; 23) who had undergone combination treatment (surgery, (35 Gy) boost tumor bed, polychemotherapy) extrapituitary brain tumors no later than 2 before...

Parathyroid cancer (PTC) is usually sporadic; however, it could be presented as a component of hereditary syndromes. The prevalence PTC among patients with primary hyperparathyroidism (PHPT) about 1% cases. lack reliable preoperative predictors significantly complicates the diagnosis PTC. clinical course non-specific and in most cases determined by severe hypercalcemia. final can only made on basis invasive histopathologic features, while an analysis immunohistochemical (IHC) one used...

The implementation of standardized protocols for combined treatment cancer into clinical practice inevitably leads to a long-term consequence.To study the prevalence endocrine disorders, assess and degree decline bone mineral density (BMD) in individuals who have undergone malignant brain tumors childhood adolescence.A retrospective was conducted with 59 young adults (31 men; 28 women) surgical tumour followed by radiation (craniospinal combination or without polychemotherapy). Group I...

Cushing’s syndrome accounts for approximately 20–30% of endogenous hypercortisolism cases, and adrenal involvement can be either unilateral or bilateral. due to bilateral tumors is extremely rare. Adrenal oncocytomas are another rare cause hypercortisolism: about 13 cases described in the literature. Oncocytomas epithelial neoplasms, characterized by abnormally excessive accumulation defective mitochondria cytoplasm cells, make up 1.8% all neoplasms. We describe a 58-year old...

Laboratory diagnosis of endocrine diseases has undergone many important changes over the past decades, despite progress thyroid function immunoassays technologies interferences cannot be completely excluded. These can affect measurement analyte which leads to misinterpretation and subsequent wrong clinical decisions, probability is about 1%. However, scale problem may greater due lack awareness among doctors laboratory screening for interfering factors. factors both endogenous exogenous,...

Medulloblastoma is the most common childhood malignant tumor of posterior cranial fossa. A comprehensive treatment approach, including surgery, polychemotherapy and radiation therapy, inevitably leads to development various long-term consequences from endocrine system, a negative impact on bone tissue. Reduced linear growth rate, low adult height peak mass are well-known effects treatment. Based data Russian foreign researchers, as well our own experience, this review presents tumors central...

BACKGROUND: The most of the current studies include patients who are different by etiology secondary adrenal insufficiency (SAI), or investigate SAI among other late effects radiation therapy. AIMS: To describe features and to select best method screening in adult followed complex treatment nonpituitary brain tumors childhood. MATERIALS AND METHODS: It was retrospective cross-sectional study. 31 after childhood 20 healthy volunteers were examined. Age sex ratio comparable between groups....