A5026219544- Thyroid Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Thyroid and Parathyroid Surgery
- Cancer-related Molecular Pathways
- Cleft Lip and Palate Research
- Head and Neck Cancer Studies
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Genetic factors in colorectal cancer
- Bone health and treatments
- Thyroid Disorders and Treatments
- Parathyroid Disorders and Treatments
- Tracheal and airway disorders
- Prostate Cancer Treatment and Research
- Medical and Biological Sciences
- Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Neuroendocrine Tumor Research Advances
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- Renal cell carcinoma treatment
- Biomedical Text Mining and Ontologies
- Head and Neck Anomalies
- Prostate Cancer Diagnosis and Treatment
Ministry of Health of the Russian Federation
2017-2025
Endocrinology Research Center
2020-2025
Institute of Endocrinology
2021
P.A. Hertzen Moscow Oncology Research Institute
2017-2020
Differentiated thyroid cancer (DTC) has a fairly favorable prognosis and high overall survival (OS). However, approximately 10-15% of patients develop distant metastases, primarily to the lungs. No uptake radioactive iodine 131I during first course therapy (RAI-T) or absence significant response RAI-T can be noted in 20-50% with advanced forms disease, which enables them classified as RAI-T-resistant (RAIR). The for RAIR is less favorable, 5-year OS 50%, compared 10-year up 98% nonaggressive...
Introduction. Given the relatively favorable prognosis in highly differentiated thyroid cancer and improvement diagnosis of disease, an assessment patients’ life quality risk developing surgical complications comes to fore. The lack studies recommendations regarding volume resection patients with tumors limited by its isthmus does not allow determining what surgery is optimal, especially for at low relapse. Aim. To determine advantages disadvantages isthmusectomy as a method treating nodular...
DNA repair can prevent mutations and cancer development, but it also restore damaged tumor cells after chemo radiation therapy. We performed RNA sequencing on 95 human pathological thyroid biosamples including 17 follicular adenomas, 23 cancers, 3 medullar 51 papillary cancers 1 poorly differentiated cancer. The gene expression profiles are annotated here with the clinical histological diagnoses and, for BRAF V600E mutation status. molecular pathway analysis showed strongly upregulated...
Introduction . Facial nerve paralysis disconnects person»s emotions and expression, causes lagophthalmos, disorders of taste, touch, salivation, lymph efflux in the damaged area. Among consistent facial conduction defects, most common is iatrogenic injury during extensive surgical interventions for removal tumors parotid gland. Various surgery are used correction such disorders. The article objective to present results performed static plastic surgeries using polypropylene thread patients...
A 59-year-old male presented with an accidental thyroid mass in 2022. Ultrasound and CT scan showed a nodule 5.2 × 4.9 2.8 cm (EU-TIRADS 4) the right lobe of gland. Taking into account results fine needle aspiration biopsy (Bethesda V), intrathyroid localization, absence clinical symptoms, malignant tumor gland was suspected. The patient underwent total thyroidectomy using fluorescence angiography indocyanine green, two pairs intact parathyroid glands were visualized typical localization....
Background . Combination therapy is the main method used for treatment of patients with locally advanced cancer oral floor and tongue. Radical surgery a key stage this therapy. These surgeries are inevitably associated extensive defects in cavity tongue and, therefore, loss necessary organism functions. Currently, there no optimal autotransplant reconstruction after total or subtotal removal muscles; it appears to be one most significant challenges modern reconstructive surgery. Materials...
Anaplastic thyroid cancer is one of the most aggressive and fatal human carcinomas. A significant experience in using various kinase inhibitors for anaplastic therapy has been accumulated worldwide. The encouraging results were obtained after a combination b-Raf MEK (vemurafenib/dabrafenib trametinib/cobimetinib, respectively) treatment unresectable BRAF V600E -positive cancer. This drug makes it possible to perform surgery followed by chemoradiotherapy other targeted therapies. Here we...
Objectives: present our experience tongue microsurgical reconstruction in patients with oral caner Т2-Т4аN+M0. Material and methods: prospective study of cases oropharyngeal zone defects after radical operations for cancer from 2015 to 2017 microsurgery department P. Hertsen Moscow Oncology Research Institute. Total 18 included study. We used flaps post-resection defects: small intestine flap (2), radial forearm (10), thoracodorsal (2) chimeric LDM+ serratus anterior muscle (4). Results:...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Thyrotoxicosis is a condition caused by an excess of thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3), in the body, leading to corresponding clinical manifestations. One main challenges differential diagnosis various forms thyrotoxicosis similarity presentation diseases. Therefore, tools for accurate verification wide spectrum nosologies are correct sequence laboratory instrumental investigations subsequent interpretation obtained results. Only accurately established...
Опухоли ГОЛОВЫ и ШЕИ HEAD and NECK tumors Том 6
Introduction. Anaplastic thyroid cancer (ATC) is a very rare malignant tumor of the comprising 1–2 % all cancers. In this pathology, response rate for standard systemic therapy less than 15 %, and long-term results remain unsatisfactory. Additionally, there are no data conclusively showing that cytotoxic chemotherapy improves survival or quality life in patients with ATC. Aim. To improve treatment ATC through evaluation effectiveness targeted cases BRAF V600E mutation. Materials methods. The...
OBJECTIVES . Diffuse and nodular goiter are the most common thyroid gland (thyroid) diseases in children adults living iodine-deficient regions. Thyroid hormone potentiates progressive hypertrophy hyperplasia of thyrocytes, with uneven proliferation cells leading to nodule formation. Iodine deficiency, which promotes replication follicular cells, also increases incidence TSH Receptor mutations, receptor activation autonomous functioning follicles. AIM To evaluate describe ultrasound...
Well differentiated thyroid cancer (WDTC) is referred to non-aggressive tumors with a relatively favorable course. However, in 10% of cases, distant metastases are recorded this pathology, them 5–15% cases develop refractoriness I131 therapy. Resistance radioactive iodine therapy patients WDTC significantly worsens the overall and disease-free survival. In 2014, targeted drug Sorafenib was registered our country, as first choice for treatment metastatic radio-refractory WDTC. The article...
Distant metastasis of thyroid cancer are founded in 10% all metastases. Bone metastases 23% distant metastasis. Complications associated with metastatic skeletal involvement often lead to a deterioration the overall condition and decrease quality life patients. Surgical treatment, chemotherapy less effective, provide higher injury rate toxicity. This is reason increasing cost treatment. Bisphosphonates class drugs that prevent loss bone mass, which can prolong time releasing complications:...
This article presents a clinical case demonsratinga high metastatic potential of clear cell renal carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence lesions the sinuses in various malignant tumors depending on their morphological forms is analyzed. authors present an analysis data published for last 30 years. optimal diagnostic algorithms detect progression evaluate effectiveness treatment are considered.
In recent years, the understanding of epidemiology, symptoms and strategies for managing patients with hyperparathyroidism has changed significantly. The most common cases in clinical practice are sporadic primary hyperparathyroidism, which today ranks third prevalence among endocrine diseases (the frequency occurrence adult population is, on average, 12%). solitary parathyroid adenoma is detected up to 85% all cases. only treatment radical surgical removal pathologically altered tissue....
Mutation BRAFV600E is highly specific for papillary thyroid carcinoma. It’s detected in 40-70% of all carcinoma cases. Moreover this mutation noticed anaplastic 40-50%.This fact gives a chance to select patients and provide targeted therapy with multi-kinase inhibitors cases unresectable The influence BRAF V600E response radioactive iodine requires more evidence-based research. Existing methods determining the have different accuracy, availability cost. Other methodological aspects are also...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
ЦЕЛЬ: разработка методов культивирования трехмерных органоподобных культур (органоидов) опу-
 холей эндокринных органов, включая редкие эндокринные опухоли. Создание первой в мире коллекции
 живых раковых органоидных линий опухолей органов человека.
 МАТЕРИАЛЫ И МЕТОДЫ: исходным материалом для органоидов были свежие образцы раковой
 ткани, полученные результате хирургического удаления первичных и метастазов. Органоиды
 размножали in vitro хранили замороженном виде с...
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