A5057444889- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Bone Tumor Diagnosis and Treatments
- Breast Implant and Reconstruction
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Soft tissue tumor case studies
- Esophageal and GI Pathology
- AI in cancer detection
- RNA modifications and cancer
P.A. Hertzen Moscow Oncology Research Institute
2016-2025
Ministry of Health of the Russian Federation
2015-2024
Medical Radiological Research Center
2024
Ministry of Health
2021-2023
Colorectal cancer (CRC) is a common worldwide. The main cause of death in CRC includes tumor progression and metastasis. At molecular level, these processes may be triggered by epithelial-mesenchymal transition (EMT) necessitates specific alterations cell metabolism. Although several EMT-related metabolic changes have been described CRC, the mechanism still poorly understood. Using CrossHub software, we analyzed RNA-Seq expression profile data derived from Cancer Genome Atlas (TCGA) project....
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. CRC molecular pathogenesis heterogeneous and may be followed by mutations in oncogenes tumor suppressor genes, chromosomal microsatellite instability, alternative splicing alterations, hypermethylation CpG islands, oxidative stress, impairment different signaling pathways energy metabolism. In present work, we have studied alterations patterns genes related to metabolism CRC. Using CrossHub software, analyzed The...
The switch from oxidative phosphorylation to glycolysis in proliferating cancer cells, even under aerobic conditions, has been shown first 1926 by Otto Warburg. Today this phenomenon is known as the “Warburg effect” and recognized a hallmark of cancer. metabolic shift associated with alterations signaling pathways involved energy metabolism, including glucose uptake fermentation, regulation mitochondrial functions. Hexokinases (HKs), which catalyze step glycolysis, have identified play role...
Aggressive soft tissue angiomyxoma in the pelvic region (AAM — angiomyxoma) is an extremely rare neoplasm that develops mainly women of reproductive age. AAM can occur at any age with a characteristic solid infiltrative growth type. described as benign neoplasms intermediate malignant potential, since development local recurrence possible. In three cases, distant metastasis has been described. Radical surgery main method treatment. Hormone therapy used before high risk performing highly...
Carotid body tumor (CBT) is a form of head and neck paragangliomas (HNPGLs) arising at the bifurcation carotid arteries. Paragangliomas are commonly associated with germline somatic mutations involving least one more than thirty causative genes. However, specific functionality number these genes involved in formation has not yet been fully investigated. Exome library preparation was carried out using Nextera® Rapid Capture Kit (Illumina, USA). Sequencing performed on NextSeq 500 System...
Older age is one of the main risk factors for cancer development. The incidence prostate cancer, as a multifactorial disease, also depends upon demographic factors, race, and genetic predisposition. Prostate most frequently occurs in men over 60 years age, indicating clear association between older disease onset. Carcinogenesis followed by deregulation many genes, some these changes could serve biomarkers diagnosis, prognosis, prediction drug therapy efficacy, well possible therapeutic...
Cell metabolic reprogramming is one of the cancer hallmarks. Glycolysis activation, along with suppression oxidative phosphorylation and, to a lower extent, TCA cycle, occurs in majority malignant tumors. A bioinformatics search for glucose metabolism genes that are differentially expressed colorectal (CC) was performed using data The Cancer Genome Atlas (TCGA) Project. OGDHL an oxoglutarate dehydrogenase complex subunit, which involved cycle and indirectly responsible induction apoptosis,...
CD133 (prominin-1) is the most commonly used molecular marker of cancer stem cells (CSCs) that maintain tumor progression and recurrence in colorectal cancer. However, proteome CSCs directly isolated from tumors based on expression has never been investigated.To reveal biomarkers CD133-positive CSCs.Thirty samples were collected patients undergoing bowel resection. CD133-negative by FACS. Comparative proteomic profiling was performed LC-MS/MS analysis combined with label-free quantification....
The NETO2 gene (neuropilin and tolloid-like 2) encodes a protein that acts as an accessory subunit of kainate receptors is predominantly expressed in the brain. Upregulation has been observed several tumors; however, its role tumorigenesis remains unclear. In this study, we investigated expression breast, prostate, colorectal cancer using quantitative PCR (qPCR), well effect shRNA-mediated silencing on transcriptome changes cells. tumors, both increased decreased mRNA levels, presenting no...
The determination of factors associated with progression cervical cancer is important, both for a recurrence risk assessment and determining optimal treatment tactics. Previously, we showed the prognostic value different types tumor microvessels (MVs) in gastric breast cancer. object this research was to study morphology clinical significance early A total 65 archived paraffin blocks patients I-IIA stages squamous were investigated. Samples stained Mayer hematoxylin immunohistochemically...
Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare tumor, associated with favorable prognosis and long-term survival in patients advanced disease. However, limited data exist on systemic therapy for such patients. Herein, we present a case young woman history SPN, who progressed after multiple surgical resections chemotherapy regimens. The immunohistochemistry (IHC) showed overexpression estrogen receptors (ER) progesterone (PR) tumor tissue. patient started to receive...
HER2/neu status of breast cancer is important for treatment strategy choice, but nowadays it evaluated manually by pathologist. The automation this procedure an urgent task, because will allow to free a pathologist from routine work. But the problem cells segmentation difficult classical methods computer vision due frequent presence erythrocytic background and non-cellular elements at specimen' image. In work we propose algorithm, based on deep convolutional neural networks. Is has been...
Optimization of diagnosis and treatment patients with solitary fibrous tumor pleura, analysis overall survival disease-free survival, predictors recurrence.There were 66 pleura (26 men 40 women) aged 57.6 years (range 26-80 years). Asymptomatic course was found in 29 (44%) patients, various symptoms - 37 (56%) patients. Thoracotomy applied 36 thoracoscopy 30 Immunohistochemical examination included definition Stat6 expression.Benign variant SFT diagnosed 50 (75.7%) malignant 16 (24.3%) STAT6...
The article tells about the evolution in development of endoscopic diagnostic methods for early central lung cancer, from rigid bronchoscopes to modern high-resolution video endoscopes. current multimodal are described, including recent data on use confocal laser endomicroscopy and endocytoscopy which allow detect lesions caused by intramucosal cancer tracheobronchial tree as well study cellular-level morphology vivo. Long-term clinical experience P.A. Herzen Moscow Oncology Research...
Purpose . Comparative analysis of the diagnostic value traditional cytology (TC) and liquid (LC) in identification cervical intraepithelial neoplasia (CIN) cancer (CC). Patients methots The study included 87 women aged 18 to 80 years. All were referred with suspicion CIN, or underwent a control cytological examination after treatment for CIN cancer. Smears taken separately from ecto-, endocervix mixed. Various tools used (trowel, brushes type D, F Cervex-Brush Combi). Each patient was...