A5057058540- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Diabetes Treatment and Management
- Lung Cancer Diagnosis and Treatment
- Pancreatic function and diabetes
- Diabetes Management and Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Organophosphorus compounds synthesis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Esophageal and GI Pathology
- Cancer Research and Treatments
- Sulfur-Based Synthesis Techniques
- Gastric Cancer Management and Outcomes
- Analytical Chemistry and Sensors
- Bladder and Urothelial Cancer Treatments
- Organic and Inorganic Chemical Reactions
- Monoclonal and Polyclonal Antibodies Research
- Bone Tumor Diagnosis and Treatments
- Neuroendocrine Tumor Research Advances
- Transplantation: Methods and Outcomes
- Healthcare Systems and Public Health
- Metastasis and carcinoma case studies
- Receptor Mechanisms and Signaling
Health Decisions (United States)
2025
Institute of Numerical Mathematics
2024-2025
Russian Academy of Sciences
2024-2025
Sirius University of Science and Technology
2022-2024
St Petersburg University
1997-2023
Victor (Japan)
2023
P.A. Hertzen Moscow Oncology Research Institute
2003-2019
Research Institute of Emergency Care
2012-2019
InSysBio (Russia)
2013
Rostov State Medical University
2011
Background & AimsDisturbances of the enterohepatic circulation bile acids (BAs) are seen in a number clinically important conditions, including metabolic disorders, hepatic impairment, diarrhea, and gallstone disease. To facilitate exploration underlying pathogenic mechanisms, we developed mathematical model built on quantitative physiological observations across different organs.MethodsThe consists set kinetic equations describing syntheses cholic, chenodeoxycholic, deoxycholic acids, as...
Abstract Aim To develop a quantitative drug‐disease systems model to investigate the paradox that sodium‐glucose co‐transporter (SGLT)2 is responsible for >80% of proximal tubule glucose reabsorption, yet SGLT2 inhibitor treatment results in only 30% 50% less reabsorption patients with type 2 diabetes mellitus (T2DM). Materials and methods A physiologically based four‐compartment renal filtration, excretion via SGLT1 was developed as system ordinary differential equations using...
The aim of this research was to differentiate dapagliflozin, empagliflozin, and canagliflozin based on their capacity inhibit sodium‐glucose cotransporter (SGLT) 1 2 in patients with type diabetes using a previously developed quantitative systems pharmacology model renal glucose filtration, reabsorption, excretion. analysis pooled, mean study‐level data 24‐hour urinary excretion, average daily plasma glucose, estimated glomerular filtration rate collected from phase I II clinical trials...
A series of [Ir(
Abstract Background and Objectives Bile acids ( BA s) traversing the enterohepatic circulation EHC ) influence important metabolic pathways. By determining individual serum s in relation to markers of activity, we explored how diurnal variations their relate hepatic metabolism normal humans. Methods Serum s, fibroblast growth factor 19 FGF 19), lipoproteins, glucose/insulin cholesterol syntheses were monitored for 32 h 8 healthy males. Studies conducted at basal state during initiation...
Synthesis of biocompatible near infrared phosphorescent complexes and their application in bioimaging as triplet oxygen sensors live systems are still challenging areas organometallic chemistry. We have designed synthetized four novel iridium [Ir(N^C)2(N^N)]+ (N^C–benzothienyl-phenanthridine based cyclometalated ligand; N^N–pyridin-phenanthroimidazol diimine chelate), decorated with oligo(ethylene glycol) groups to impart these emitters’ solubility aqueous media, biocompatibility, shield...
In this work, we obtained three new phosphorescent iridium complexes (Ir1-Ir3) of general stoichiometry [Ir(N^C)2(N^N)]Cl decorated with oligo(ethylene glycol) fragments to make them water-soluble and biocompatible, as well protect from aggregation biomolecules such albumin. The major photophysical characteristics these are determined by the nature two cyclometallating ligands (N^C) based on 2-pyridine-benzothiophene, since quantum chemical calculations revealed that electronic transitions...
Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in treatment hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued drug development. The objective this research is to set stage for quantitative benchmarking two pharmacological modality classes, monoclonal antibodies (mAbs) and small interfering RNA (siRNA). To end, we developed integrative mathematical model lipoprotein homeostasis describing dynamic interplay...
AZD8233 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) antisense oligonucleotide under development for treatment of hypercholesterolaemia. A prespecified concentration-QT analysis was performed based on data from single ascending dose study that prospectively designed to act as TQT substitute.Subcutaneous doses ranging 4 120 mg were evaluated in 73 adult healthy male subjects. Time-matched 12-lead digital ECG and plasma concentrations (n = 15) measured at baseline up 48 hours...
Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to reduce BCAA levels and demonstrated positive effects on function a preclinical setting. The current study focused evaluating the impact systemic their metabolites as well activities catabolic enzymes using quantitative systems pharmacology model....
Cardio-ankle vascular index (CAVI) and its modified version (CAVI0) are promising non-invasive markers of arterial stiffness, extensively evaluated primarily in the Japanese population. In this work, we performed a model-based analysis association between different population characteristics CAVI or CAVI0 values healthy Russian subjects propose tool for calculating range reference both types indices.
Three novel luminescent Eu(III) complexes, Eu1-Eu3, have been synthesized and characterized with CHN analysis, mass-spectrometry 1H NMR spectroscopy. The complexes display strong emission in dichloromethane solution upon excitation at 405 800 nm a quantum yield from 18.3 to 31.6%, excited-state lifetimes the range of 243-1016 ms 20 °C, lifetime temperature sensitivity 0.9%/K (Eu1), 1.9%/K (Eu2), 1.7%/K (Eu3). chromophores were embedded into biocompatible latex nanoparticles (NPs_Eu1-NPs_Eu3)...
Photosensitizer Photosens is a mixture of sulphonated Al-phthalocyanines with different number substituents per phthalocyanine molecule. In the beginning 1994, this photosensitizer was approved for clinical trials. Since that time till May 1995, 45 patients 120 tumors were treated by PDT-Photosens. The main tumor localizations lung (5/6), head and neck (4/4), esophagus (8/8), stomach (2/2), vulva bladder (1/1), breast cancer (3/3), skin (basalioma, melanoma, sarcoma Kaposi, mts cancer) (20...
After experimental investigation clinical trials of photodynamic therapy (PDT) with the new photosensitizer Photosens -- (AL-sulphonated phthalocyanine) have been started. Four patients (with basal cell carcinoma, sarcoma Kaposi and early stage lung cancer) were treated by PDT. an intravenous injection drug in dose 2.0 mg/kg b.w. tumors exposed to frequency-doubled radiation Nd:yttrium aluminate laser (670 nm) power densities from 80 200 mW/sq cm total energies up 2144 J. Immunological...
Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people and caused by a reaction to the gluten protein found wheat, which leads intestinal villous atrophy. Currently there no drug for treatment of CD. The only known lifelong gluten-free diet. main aim this work develop mathematical model immune response CD patients predict efficacy transglutaminase-2 (TG-2) inhibitor as potential CD.A thorough analysis developed provided following results:1. TG-2...
The first clinical trials of photodynamic therapy (PDT) in Russia were started P. A. Hertzen Moscow Research Oncology Institute October 1992. Up to now, 61 patients with primary or recurrent malignant tumors the larynx (3), trachea (1), bronchus (11), nose mouth esophagus (12), vagina and uterine cervix bladder (2), skin (6), cutaneous subcutaneous metastases breast cancer melanomas (6) have been treated by PDT photosensitizer Photogem. At least partial tumor response was observed all cases,...
Fourier transform IR fiberoptic evanescent wave spectroscopy has been suggested as a powerful tool for clinical diagnostics of normal, precancerous, and cancerous breast tissue ex vivo in vitro the middle region spectrum. This method is suitable noninvasive direct measurements spectra normal pathological tissues vitro, vivo. For first time this used nondestructively, rapidly, fast remotely operating rooms clinics. The aim our studies express testing various tumor during surgery to optimize...