A5072881107- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Laser-Ablation Synthesis of Nanoparticles
- Chemical Reactions and Isotopes
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Surface Roughness and Optical Measurements
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Free Radicals and Antioxidants
- Water Quality Monitoring and Analysis
- Light effects on plants
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Nanoparticle-Based Drug Delivery
- Radiation Therapy and Dosimetry
- Ultrasound and Hyperthermia Applications
- bioluminescence and chemiluminescence research
- Advances in Oncology and Radiotherapy
P.A. Hertzen Moscow Oncology Research Institute
2014-2024
Ministry of Health of the Russian Federation
2016-2024
Medical Radiological Research Center
2021-2024
MIREA - Russian Technological University
2022-2024
Institute of Bioorganic Chemistry
2023
The combination of radiation treatment and chemotherapy is currently the standard for management cancer patients. However, safe doses do not often provide effective therapy, then pre-treated patients are forced to repeat with already increased tumor resistance drugs irradiation. One solutions we suggest improve primary course via enhancing radiosensitivity tumors by magnetic-guided iron oxide nanoparticles (magnetite). We obtained spherical heparinized (hIONPs, ∼20 nm), characterized it TEM,...
Prostate cancer is the second most common type of among men. Its main method treatment chemotherapy, which has a wide range side effects. One solutions to this challenge targeted delivery prostate cells. Here we synthesized novel small-molecule PSMA-targeted conjugate based on monomethyl auristatin E. structure and conformational properties were investigated by NMR spectroscopy. Cytotoxicity, intracellular reactive oxygen species induction, stability under liver microsomes P450-cytochrome...
Chemotherapy is among the main classical approaches to treatment of oncologic diseases. Its efficiency has been comprehensively proven by clinical examinations; however, low selectivity chemotherapeutic agents limits possibilities this method, making it necessary search for new therapy Photodynamic least invasive method and a very efficient alternative malignant tumors; its depends on depth light penetration into tissue degree oxygenation zone. In work, hitherto unknown conjugate natural...
Background: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery tumor sites, but highly variable between patients. Identifying PS peak personalized manner crucial therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity tracking dynamics using...
Novel hybrid molecule containing 2-mercaptoethylamine was synthesized starting from O-propyloxime-N-propoxy bacteriopurpurinimide (dipropoxy-BPI), which readily oxidized in oxygen atmosphere yielding the corresponding disulfide analogue (disulfide-BPI). Spectral, photophysical, photodynamic, and biological properties of compound were properly evaluated. Compounds bearing moiety can directly interact with glutathione (GSH), thereby reducing its intracellular concentration. Indeed, mice...
Bacteriochlorin derivatives were synthesized by reacting bacteriopheophorbide methyl ether with diaminoalkanes bearing alkyl groups of different chain length. Biotests demonstrated their high in vitro phototoxicity at nanomolar concentrations against types epithelial cells, as well dose-dependent vivo antitumor efficacy tumor laden mice. At the doses 2.5 and 5.0 mg/kg, tested photosensitizers (PS) provided 100% growth inhibition response rate over 120 day follow-up period after PDT due to...
Prostate cancer is the second most common among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen suitable for bimodal conjugates with diagnostic therapeutic agents. In vitro studies of affinity compounds to protein target have been carried out. Based on these ligands, a series combination different mitosis inhibitors antiandrogenic drugs were synthesized. The cytotoxicity obtained in was investigated three cell lines. efficacy two evaluated vivo...
A regioselective synthesis of glycoconjugates based on bacteriochlorophyll a and lactose derivatives has been carried out. The conjugation was achieved via 1,3-dipolar cycloaddition bacteriochlorins containing terminal triple bond azide derivative. conjugates obtained in this way had one or two disaccharide fragments attached to pyrrol A, the exocyclic imide ring tetrapyrrolyc macrocycle, both positions. Exhaustive NMR analysis by 1D 2D experiments ( 1 H- H COSY, TOCSY, ROESY, 13 C HSQC,...
TRAIL (TNF-related apoptosis-inducing ligand) and its derivatives are potentials for anticancer therapy due to the selective induction of apoptosis in tumor cells upon binding death receptors DR4 or DR5. Previously, we generated a DR5-selective mutant variant DR5-B overcoming receptor-dependent resistance TRAIL. In current study, improved antitumor activity by fusion with tumor-homing iRGD peptide, which is known enhance drug penetration into tissues. The obtained bispecific protein...
Photodynamic therapy (PDT) is currently regarded as a promising method for the treatment of oncological diseases. However, it involves number limitations related to specific features and characteristics photosensitizer molecules, including tumor hypoxia, small depth light penetration into tissue, low accumulation sensitivity. These drawbacks can be overcome by combining PDT with other methods, example, chemotherapy. In this work, we were first obtain agents that contain bacteriopurpurinimide...
Prostate cancer is an extremely common among older men. Conventional chemotherapy has proven to be not effective enough in battling it due its high systemic toxicity and low selectivity. An alternative method of treatment known as photodynamic therapy (PDT) been shown effective. It without faults either: one the issues it’s have insufficient selectivity photosensitizer accumulation tumor tissues. Recent studies, however, seem indicate that introducing a PSMA-targeted moiety into might prove...
Combined therapy is currently a popular method for increasing the efficiency of antitumor treatment. It involves use two different tumor treatment methods, namely, chemotherapy and PDT. Combining cytotoxic agent photosensitizer in single molecule results synergistic effect that overcomes multiple drug resistance reduces therapeutic doses. In this work, pyridine-containing natural chlorins were obtained by introducing pyridine group into 13 1 -[Formula: see text]-(4-aminobutyl)amide chlorin...
The development of sulfur-containing pharmaceutical compounds is important in the advancement medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation groups or individual sulfur atoms into their structure are not neglected, either. In this work, a synthesis derivatives natural chlorophyll using Lawesson's reagent was optimized. Thiocarbonyl chlorins were shown to have significant bathochromic shift absorption and fluorescence bands. feasibility...
Determination of the iron oxide nanoparticles (IONPs) local temperature during laser heating is important in aspect phototherapy. We have carried out theoretical modeling IONPs electromagnetic (EM) field enhancement and under action near individual ensembles with different sizes, shapes chemical phases. For experimental determination temperature, we used fluorescence thermometry rhodamine B (RhB) based on its lifetime. Depending shape their location space, a significant change spatial...
Introduction. Bacteriochlorins are the most promising photosensitizers absorbing in near-infrared spectral region. Their use can enhance efficiency of photodynamic therapy due to deeper penetration radiation into tumor. Objective conduct a preclinical study photoinduced antitumor activity and biodistribution Bacteriosens. Materials methods. Bacteriosens is preparation based on meso-tetra(3-pyridyl)bacteriochlorin at 747 nm. Photoinduced cytotoxicity was investigated vitro using human tumor...
This paper presents a primary screening of bacteriochlorin-type compounds with aminoamide, propyl and carbohydrate substituents aimed for development new generation photosensitizers (PS) photodynamic therapy malignant tumors. Absorption fluorescence spectral characteristics the compounds, their storage stability in solutions under dark conditions light exposure, photo-induced cytotoxicity against human HEp2 tumor cells have been studied. It has shown that dyes aminoamide an absorbtion...
The article describes the process of developing a technology for producing nanoparticles based on copolymer lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) photodynamic therapy malignant tumors various origins. Technological parameters optimizing method in order to obtain with specified characteristics are presented this paper. As result, sample an average particle diameter 222.6±2.8 nm; ξ-potential 26.3±4.61 mV; polydispersity index 0.144; total content...
Local determination of the iron oxide nanoparticles (IONPs) temperature during laser heating is important in aspect phototherapy. We have carried out theoretical modeling local EM field enhancement and under action near individual IONPs ensembles NPs with different sizes magnetic core content them. To experimental determine water colloids, we used fluorescence thermometry based on rhodamine B (RhB) lifetime. strongly depend shape distance between In case anisotropic NPs, a significant change...