A5051863901- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Ferrocene Chemistry and Applications
- Photochromic and Fluorescence Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Cancer Research and Treatments
- Radioactive element chemistry and processing
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Porphyrin Metabolism and Disorders
- Photosynthetic Processes and Mechanisms
- bioluminescence and chemiluminescence research
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Advanced ceramic materials synthesis
- Photoreceptor and optogenetics research
- Aluminum Alloys Composites Properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
MIREA - Russian Technological University
2004-2025
Moscow State University of Fine Chemical Technologies
2012-2023
Moscow Architectural Institute
2004-2023
Moscow State Technological University
2018
Applied BioPhysics (United States)
2016
Optica
2016
N. I. Lobachevsky State University of Nizhny Novgorod
2016
Institute of Bioorganic Chemistry
2016
Privolzhsky Research Medical University
2016
Laboratoire des Biomolécules
2016
The review discusses the latest advances in directed synthesis and application of macroheterocyclic compounds science, engineering technology, viz.as catalysts for various processes photo-and electrocatalysis, optical chemosensors metal cations, selective receptors organic compounds, inductors selectors, nonlinear optics, electronics, as magnets, photosensitizers PDT a number oncological diseases antimicrobial PDT, etc.
The synthesis of the acetonitrilium and propionitrilium derivatives closo-dodecaborate [B12H12]2- was discussed. nucleophilic addition reactions water, alcohols secondary amines to activated triple bond nitrilium yielded corresponding iminols, imidates amidines. obtained results were supported by X-ray diffraction studies DFT calculations.
The review summarizes the chemistry of third generation photosensitizers, namely, derivatives natural bacteriochlorophyll a, for photodynamic treatment cancer. compounds this class strongly absorb light at lambda=770-850 nm. This unique property opens new therapeutic opportunities due to deeper tissue penetration light, thereby increasing photodamage tumor eradication. Analyzed are modifications that improve physico-chemical characteristics and enhance accumulation in tumors. Focusing on...
The insufficient selectivity of existing local anesthetics can lead to serious adverse effects. Considering the widespread use this class drugs, development new that do not cause side effects is an important task. One approach address issue photopharmacology, which enables creation agents with light-controlled biological activity. Several examples azobenzene-based photoswitchable blockers voltage-gated sodium (Nav) channels have been described so far. These compounds be used as anesthetics,...
Abstract A major problem in the treatment of cancer is specific targeting drugs to these abnormal cells. Ideally, such a drug should act over short distances minimize damage healthy cells and target subcellular compartments that have highest sensitivity drug. We describe novel approach using modular recombinant transporters photosensitizers nucleus, where their action most pronounced, overexpressing ErbB1 receptors. produced new generation consisting (a) epidermal growth factor as...
Abstract Conjugates of chlorin e 6 with closo ‐dodecaborate and cobalt bis(dicarbollide) anions were synthesized for the first time in high yields using advanced ‘click’ methodology. In vitro study on A549 human lung adenocarcinoma cells revealed that boronated conjugates are able to penetrate accumulate cancer cells, but their intracellular concentration is not sufficient effective photodynamic boron neutron capture therapy cancer. Copyright © 2009 John Wiley & Sons, Ltd.
Theranostic upconversion nanoparticles (UCNPs) are ideal candidates for personalized medicine. We present a smart, easy-to-prepare nanohybrid (NH) suitable NIR-theragnosis and imaging tracking without triggering therapy simultaneously. The photophysical features of each component have been carefully selected in order to maximize the capabilities theragnosis, particular, emission photosensitizer absorption. In addition, NH presents fluorescent marker with one-photon absorption green...
A series of novel conjugates cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC 10702 not against Gram-negative microorganisms Candida albicans at the maximum studied concentration 1000 mg/L. The conjugate alkynyl-curcumin azide from tetrahydropyran derivative exhibited activity Gram-positive...
The Photosensitizing and fluorescence imaging ability of a bacteriochlorin–naphthalimide conjugate is studied.
Chemotherapy is among the main classical approaches to treatment of oncologic diseases. Its efficiency has been comprehensively proven by clinical examinations; however, low selectivity chemotherapeutic agents limits possibilities this method, making it necessary search for new therapy Photodynamic least invasive method and a very efficient alternative malignant tumors; its depends on depth light penetration into tissue degree oxygenation zone. In work, hitherto unknown conjugate natural...
Objectives. To synthesize Pt-containing derivatives of natural chlorins as potential agents for the combination therapy in oncology. Platinum compounds are known to occupy an important place chemotherapeutic treatment oncological diseases. However, Pt(II) complexes highly toxic body and not selectively accumulated tumor cells. If photodynamic chemotherapy methods combined a single drug, pigments responsible selectivity conjugate accumulation tumor, while agent based on is cytotoxic effect...
The nucleophilic addition of alcohols and thiols to 8-propionitrilium derivatives cobalt iron bis(dicarbollides) gives the corresponding imidates thioimidates.
The review summarizes the synthesis and study of properties bioconjugates chlorophyll a bacteriochlorophyll with carbohydrates, carboranes other moieties, focusing on synthetic methods obtaining conjugates preliminary biological testing thereof. Boronated chlorins bacteriochlorins can be used in both photodynamic boron neutron capture therapy.