A5009602779- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Ferrocene Chemistry and Applications
- Chemical Reactions and Isotopes
- Metal complexes synthesis and properties
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Retinoids in leukemia and cellular processes
- Laser-Ablation Synthesis of Nanoparticles
- Photochromic and Fluorescence Chemistry
- Blood Coagulation and Thrombosis Mechanisms
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Crystallography and molecular interactions
- Cardiovascular Issues in Pregnancy
- Mass Spectrometry Techniques and Applications
P.A. Hertzen Moscow Oncology Research Institute
2014-2025
Ministry of Health of the Russian Federation
2016-2025
Ministry of Health
2017-2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2019
Medical Radiological Research Center
2018
Karpov Institute of Physical Chemistry
2018
Weatherford College
2017
Institute of Gene Biology
2017
Moscow State University
2017
Medical Technologies (Czechia)
2012
Abstract The toxicity of ferrocenylethyl benzotriazole ( 1 ) and other ferrocene compounds including ferrocenylmethyl benzimidazoles 4,5,6,11 ), ferricenium salts 3,9,10 adenine 7 was studied. All complexes under investigation showed low or medium toxicities. On the basis an earlier model chemical carcinogenesis, antitumor activity ferrocenylalkyl azoles 1, 8 9, 10 studied in vivo so‐called sub‐capsular test on human tumors. This effectiveness compared with that cisplatin. A series were...
Abstract On the basis of an earlier model chemical carcinogenesis, antitumor activity mono‐, bi‐ and poly‐nuclear ferrocene derivatives ferricenium tri‐iodide (1), tetrachloroferrate (2), 1, 1′‐diethylferricenium triiodide: (3), N ‐(ferrocenylmethyl)hexamethylenetetramine tetrafluoroborate (4), bis(ferrocenylmethyl)benzotriazolium (5), bis(ferrocenyl‐α‐ethyl)benzotriazolium (6) bis(ferrocenylmethyl)‐2‐methylbenzimidazolium (7), oligomer (—Fc—CH 2 —Fc +˙ —CH —) 7–8 − (PF 6 ) (8) was studied...
Gamma-ray emitting 111In, which is extensively used for imaging, also a source of short-range Auger electrons (AE). While exhibiting negligible effect outside cells, these AE become highly toxic near DNA within the cell nucleus. Therefore, radionuclides can be as therapeutic anticancer agent if delivered precisely into nuclei tumor target cells. Modular nanotransporters (MNTs) designed to provide receptor-targeted delivery cargoes cells are perspective candidates specific intracellular...
The insufficient selectivity of existing local anesthetics can lead to serious adverse effects. Considering the widespread use this class drugs, development new that do not cause side effects is an important task. One approach address issue photopharmacology, which enables creation agents with light-controlled biological activity. Several examples azobenzene-based photoswitchable blockers voltage-gated sodium (Nav) channels have been described so far. These compounds be used as anesthetics,...
Purpose: Modular nanotransporters (MNTs) are a polyfunctional platform designed to achieve receptor-specific delivery of short-range therapeutics into the cell nucleus by receptor-mediated endocytosis, endosome escape, and targeted nuclear transport. This study evaluated potential utility MNT in tandem with Auger electron emitting 111 In for cancer therapy. Methods: Three MNTs developed target either melanocortin receptor-1 (MC1R), folate receptor (FR), or epidermal growth factor (EGFR) that...
The Photosensitizing and fluorescence imaging ability of a bacteriochlorin–naphthalimide conjugate is studied.
Bacteriochlorin derivatives were synthesized by reacting bacteriopheophorbide methyl ether with diaminoalkanes bearing alkyl groups of different chain length. Biotests demonstrated their high in vitro phototoxicity at nanomolar concentrations against types epithelial cells, as well dose-dependent vivo antitumor efficacy tumor laden mice. At the doses 2.5 and 5.0 mg/kg, tested photosensitizers (PS) provided 100% growth inhibition response rate over 120 day follow-up period after PDT due to...
Determination of the iron oxide nanoparticles (IONPs) local temperature during laser heating is important in aspect phototherapy. We have carried out theoretical modeling IONPs electromagnetic (EM) field enhancement and under action near individual ensembles with different sizes, shapes chemical phases. For experimental determination temperature, we used fluorescence thermometry rhodamine B (RhB) based on its lifetime. Depending shape their location space, a significant change spatial...
Introduction. Bacteriochlorins are the most promising photosensitizers absorbing in near-infrared spectral region. Their use can enhance efficiency of photodynamic therapy due to deeper penetration radiation into tumor. Objective conduct a preclinical study photoinduced antitumor activity and biodistribution Bacteriosens. Materials methods. Bacteriosens is preparation based on meso-tetra(3-pyridyl)bacteriochlorin at 747 nm. Photoinduced cytotoxicity was investigated vitro using human tumor...
The substituted phthalocyanine complex cholosens was in vivo investigated as a photosensitizer used photodynamic therapy (PDT) for malignancies. Cholosens immediately accumulates the tissues of murine tumors (Lewis lung carcinoma (LLC), colon adenocarcinoma 26 (C26), sarcoma 37 (S37), and melanoma B16) imaged by fluorescence to show contrast tumor compared adjacent tissue from 2 4 conventional units. maximum λ тах = 696.5 nm is recorded 5-30 minutes after injection. has high photo-induced...
The article describes the process of developing a technology for producing nanoparticles based on copolymer lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) photodynamic therapy malignant tumors various origins. Technological parameters optimizing method in order to obtain with specified characteristics are presented this paper. As result, sample an average particle diameter 222.6±2.8 nm; ξ-potential 26.3±4.61 mV; polydispersity index 0.144; total content...
This modern literature review covers the results of study tubulin inhibitors, mainly combretastatins A-4 and A-1 (CA-4 CA-1) or colhicinoids. The article presents data SAR (Structure Activity Relation) numerous CA-4 analogues as well mechanisms their action evaluated in vitro (using cultured tumor cells) vivo animals with transplanted murine tumors xenografts human various histogenesis). phosphate derivative (CA-4P) is characterized a vascular disrupting agent (VDAs). Approaches are...
Objective of the study. To evaluate pharmacological effects N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-glutamic acid (GMDP-A) as a modifier biological reactions, i. e. to study its modifying action in regard traditional cytostatic chemotherapy. Materials and methods. The used drug agents were GMDP-A, cisplatinum, gemcitabine, cyclophosphamide, 5-fluorouracil. transplanted murine tumors Р-388 lymphocytic leukemia S-37 sarcoma (solid ascites variants), B-16 melanoma, CC-5 squamous cell...