A5101771411- Inorganic and Organometallic Chemistry
- Analytical Chemistry and Chromatography
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advancements in Transdermal Drug Delivery
- Venous Thromboembolism Diagnosis and Management
- Drug Solubulity and Delivery Systems
- Process Optimization and Integration
- Statistical and Computational Modeling
- Advanced Drug Delivery Systems
- Chemical Synthesis and Reactions
- Biochemical effects in animals
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Methods in Pharmaceuticals
- Photodynamic Therapy Research Studies
- Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- Thermal and Kinetic Analysis
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Protein Interaction Studies and Fluorescence Analysis
- Biochemical Acid Research Studies
- Chemical synthesis and pharmacological studies
- Protein purification and stability
- Advanced Glycation End Products research
- Engineering Technology and Methodologies
MIREA - Russian Technological University
2019-2025
Moscow State University of Fine Chemical Technologies
2011-2019
Moscow State Technological University
2019
Skolkovo Institute of Science and Technology
2019
Moscow Institute of Thermal Technology
2017
Lomonosov Moscow State University
2013-2016
Pharmaceutical Biotechnology (Czechia)
2012-2014
Medical Technologies (Czechia)
2013
Introduction. Direct compression is one of the most preferred methods for production tablet dosage forms in terms efficiency, since it allows you to minimize technological process down level "mixing-tableting-filling and packaging". However, this method requires excipients that have appropriate flowability compressibility. One widely used examples such granulated lactose. In work, samples pure lactose were produced by fluid bed granulation high shear order compare properties product obtained...
The article discusses the development of algorithmic and software for an intellectual control system synthesis active pharmaceutical ingredients.Based on analysis scheme quality system, efficiency safety medical products, authors showed that only non-certified stage in life cycle production medicines is stage, which includes APIs GLF composition development.The advantage continuous ingredients over periodic scheme.The gave a systematic approach to proposed based implementation QbD...
The article considers the application of system approach for constructing informational support life cycle production medicinal products. principal difficulties creating a single entire are considered in this article. A brief analysis information and computer individual links is given. Particular attention paid to use systematic creation pharmaceutical development medicines. principle QbD - “Quality planned development” was taken as basis. For implementation on basis approach, it proposed...
The article describes the process of developing a technology for producing nanoparticles based on copolymer lactic and glycolic acids (PLGA) containing dipropoxybacteriopurpurinimide (DPBPI) photodynamic therapy malignant tumors various origins. Technological parameters optimizing method in order to obtain with specified characteristics are presented this paper. As result, sample an average particle diameter 222.6±2.8 nm; ξ-potential 26.3±4.61 mV; polydispersity index 0.144; total content...
The present work is devoted to study of the antimicrobial activity a new promising synthetic biocidal compound, branched oligohexamethylene guanidine hydrochloride. studies were carried out using optional anaerobic bacteria Staphylococcus aureus and Klebsiella pneumoniae, as well obligate Actinomyces pyogenes, odontolyticus, Peptostreptococcus micros, Finegoldia magna, Veillonella parvula, Prevotella disiens Fusobacterium nucleatum. It was shown that hydrochloride inhibits growth these...
Introduction. Dissolving polymeric microneedles are attractive drug delivery system especially for vaccine delivery. Still there a lot of obstacles in developing scalable manufacturing process them. Aim. To develop producing dissolving microneedles, which can enable keeping protein activity during process. Materials and methods. Microneedles were produced from aqua solution 20 % w.v. pullulan 3 polyvinyl alcohol by casting hollow negative polyethylene terephthalate mold. Human serum albumin...
Introduction. Polymeric dissolving microneedles are promising way for drug delivery especially vaccine delivery. It is an important task to create a scalable of manufacture polymeric microneedles. First step in this process easy and cheap producing negative master-molds Objective. To develop the laser production technology master-mold Material methods. Possibility using different polymer plates (polydimethylsiloxane, polycarbonate, polystyrene, polypropylene, polymethyl methacrylate...
Introduction. «Dissolution test» for drugs is one of the key studies control and, in many ways, designed to simulate bioavailability active substance under conditions use. However, there are several containing pharmaceutical substances that poorly soluble standard conditions. For this action local, so, they practically not absorbed human body, but showed necessary therapeutic effect. This work discusses development lipophilic-based suppositories natamycin, which an antifungal agent related...
Objectives. The introduction of digital tools for the development medicines, intelligent management systems, and quality control is stipulated not only by modern requirements chemical pharmaceutical industry but also strict regulatory manufactured products. This principle ensures release a product on first attempt. aim this study to develop information support system production active substances (APSs) medicines using fundamentally new technology: continuous synthesis in flow microreactors....
Disulfiram (DSF) was successfully used to treat cataract one of the most common eye disease. Unfortunately usage DSF in ophthalmology is limited due its low solubility water. The objective this article propose a new way product an inclusion complex with hydroxypropil-?-cyclodextrin (HP?CD) that allows enhancing drug's prepared by dissolving dry samples HP?CD and ethyl alcohol molar ratio 2:1. To confirm formation establish structure we differential scanning calorimetry, nuclear magnetic...