A5017968948- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Protein purification and stability
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Polymer Synthesis and Characterization
- Medicinal plant effects and applications
- Neurological Disorders and Treatments
- Crystallization and Solubility Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Adsorption, diffusion, and thermodynamic properties of materials
- Biochemical effects in animals
- Chromatography in Natural Products
- 3D Printing in Biomedical Research
- Computational Drug Discovery Methods
- Medical and Biological Sciences
- Gas Dynamics and Kinetic Theory
- Biopolymer Synthesis and Applications
- Additive Manufacturing and 3D Printing Technologies
- Chemical Thermodynamics and Molecular Structure
- Chemical synthesis and pharmacological studies
- Nanoparticle-Based Drug Delivery
- Fluid Dynamics and Heat Transfer
- Advanced Scientific Research Methods
Russian Academy of Sciences
2009-2025
Institute of Pharmacology Russian Academy of Medical Sciences
2010-2024
Military Space Academy named after AF Mozhaisky
2012-2023
Institute of Pharmacology
2020-2022
Samara Medical Institute Reaviz
2017-2021
Pharmaceutical Biotechnology (Czechia)
2014
Academy of Medical Sciences
2009-2013
Federal State Budgetary Institution "Center for Expertise and Quality Control of Medical Care"
2010
Peoples' Friendship University of Russia
2004
Amorphous solid dispersion (ASD) technology is often used as a promising strategy to improve the solubility of active pharmaceutical ingredients (APIs). ASDs allow APIs be dispersed at molecular level in polymer carrier, destroying crystalline structure and, thanks polymer, providing long-term supersaturation solution. However, stability issues are an obstacle development new medications with ASD. In addition mobility elevated temperatures leading crystallization APIs, moisture affects...
Epiphytic lichens are integral to boreal forest ecosystems, yet their allelopathic interactions with host trees, particularly in cryolithozone regions, remain poorly understood. This study elucidates the physiological and biochemical impacts of epiphytic lichen Physcia alnophila on Larix gmelinii (Gmelin larch), a keystone species Siberian permafrost forests. By combining dendrochronology, GC–MS metabolomic analysis, HPLC–ESI–MS/MS we demonstrate that lichen’s primary metabolite, atranorin...
To this day, the proper production of medicines according to Good Manufacturing Practice (GMP) largely depends on professional training pharmaceutical staff. This article describes approaches selection and employees enterprises methods for evaluating staff knowledge.
This work aimed to develop and characterize a water-soluble, high-release active pharmaceutical ingredient (API) composite based on the practically water-insoluble API N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-3), substance with antidepressant anxiolytic action. allows ensure bioavailability of medicinal product combined Composites obtained by method creating amorphous solid dispersions, where polyvinylpyrrolidone (PVP) or Soluplus® was used as polymer, were studied...
Lyophilization of protein and peptide anticancer drugs is a promising method to create stable effective parenteral dosage forms. This article reviews the main problems encountered during lyophilization drugs, describes best practices for solving these problems. The ways optimization improvement freeze-drying are given. Temperatures improve properties prevent destruction cake lyophilizatiе suggested.
N-butyl-N-methyl-1-phenylpyrrole[1,2-a] pyrazine-3-carboxamide (GML-3) is a potential candidate for combination drug therapy due to its anxiolytic and antidepressant activity. The activity of GML-3 comparable diazepam. amitriptyline. an 18 kDa mitochondrial translocator protein (TSPO) ligand devoid most the side effects diazepam, which makes research on creation drugs based it promising. However, low water solubility tendency agglomerate prevented release. This aimed study effect dry...
Nearly 40% of novel chemical entities show evidence low solubility in water and bioavailability. Self-emulsifying formulations have showed the power to improve bioavailability hydrophobic drugs. belong lipid formulations, their size range from 100 nm case self-emulsifying drug delivery systems less than 50 self-microemulsifying systems. In general s represent isotropic mixtures oils, surfactants co-surfactants, which emulsify spontaneous aqueous media under conditions gentle stirring....