A5036603201- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Photoreceptor and optogenetics research
- Glioma Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Synthesis and Reactions of Organic Compounds
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neural Engineering
- Synthesis and Biological Evaluation
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Endometrial and Cervical Cancer Treatments
- ATP Synthase and ATPases Research
Institute of Bioorganic Chemistry
2022-2024
Lomonosov Moscow State University
2023
TRAIL (TNF-related apoptosis-inducing ligand) and its derivatives are potentials for anticancer therapy due to the selective induction of apoptosis in tumor cells upon binding death receptors DR4 or DR5. Previously, we generated a DR5-selective mutant variant DR5-B overcoming receptor-dependent resistance TRAIL. In current study, improved antitumor activity by fusion with tumor-homing iRGD peptide, which is known enhance drug penetration into tissues. The obtained bispecific protein...
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. One of reasons for resistance GBM to treatment extreme heterogeneity tumor and, in particular, presence cancer stem cells (CSCs) population glioblastoma cells. In this work, we investigated effect conditions that reduce proportion CSCs cell on levels long noncoding RNAs (lincROR and MALAT1) involved formation phenotype We have shown culturing under cause a decrease stemness (when fetal bovine serum added culture...
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, with a poor prognosis. GBM cells, which develop in environment neural tissue, often exploit neurotransmitters and their receptors to promote own growth invasion. Nicotinic acetylcholine (nAChRs), play crucial role central nervous system signal transmission, are widely represented brain, cells express several subtypes nAChRs that suggested transmit signals from neurons, promoting tumor invasion growth. Analysis...
Objective. To study and determine the prognostic value of long non-coding RNA (lncRNA) expression (MALAT1 Linc-ROR)in reproductive-aged patients with endometrial hyperplasia (EH) adenocarcinoma. Patients methods. The included 120 patients. Depending on results histological examination, were distributed into groups (n = 58), adenocarcinoma 14), normal histology 48). Using molecular genetic testing, lncRNA levels determined by real-time reverse transcription polymerase chain reaction. Results....
Clinical and morphological features of rapidly growing myomatous nodes, as well their frequent combination with endometrial hyperplasia, endometriosis functional ovarian cysts suggest that development is due to disorders caused by sex steroids, realized through cell proliferation impaired apoptosis, which requires a comprehensive approach both in treatment the recovery period. Objective. To identify correlation between relative expression levels genes different subunits nicotinic...
ABSTRACT Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a poor prognosis. GBM cells, developing in environment neural tissue, often exploit neurotransmitters and their receptors to promote growth invasion. Nicotinic acetylcholine (nAChRs) play crucial role central nervous system signal transmission, are widely represented brain, cells expressing several subtypes nAChRs which suggested transmit signals from neurons, thus promoting tumor invasion growth....
Objective. To study and evaluate the expression patterns of different subunits nicotinic acetylcholine receptors (nAChRs) in reproductive-aged patients with ovarian endometriosis. Patients methods. This included 60 who were divided into two groups: group 1 – women endometriosis, 2 control group. During surgical treatment, all underwent biopsy followed by RNA isolation, reverse transcription, real-time polymerase chain reaction, obtaining primary endometriosis cell cultures further assessment...
ABSTRACT Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. One of reasons for resistance MGB to treatment extreme heterogeneity tumor and, in particular, presence cancer stem cells (CSCs) population glioblastoma cells. In this work, we investigated effect conditions that reduce proportion CSCs GBM cell on levels long noncoding RNAs (lincROR and MALAT1) involved formation phenotype We have shown culturing under cause a decrease stemness (when fetal calf serum added...