A5002234927- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nigella sativa pharmacological applications
- Polymer Surface Interaction Studies
- Cell death mechanisms and regulation
- Advanced Biosensing Techniques and Applications
- Biopolymer Synthesis and Applications
- Advanced Fluorescence Microscopy Techniques
- Curcumin's Biomedical Applications
- Cellular Mechanics and Interactions
- Antioxidant Activity and Oxidative Stress
- biodegradable polymer synthesis and properties
- Nanoplatforms for cancer theranostics
- bioluminescence and chemiluminescence research
- Force Microscopy Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Dendrimers and Hyperbranched Polymers
- Chemical Synthesis and Analysis
- Advanced Polymer Synthesis and Characterization
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
Institute of Bioorganic Chemistry
2016-2024
Institute of Bioorganic Chemistry
2023-2024
D. Mendeleyev University of Chemical Technology of Russia
2024
Recently, biodegradable polyelectrolyte multilayer capsules (PMC) have been proposed for anticancer drug delivery. In many cases, microencapsulation allows to concentrate the substance locally and prolong its flow cells. To reduce systemic toxicity when delivering highly toxic drugs, such as doxorubicin (DOX), development of a combined delivery system is paramount importance. Many efforts made exploit DR5-dependent apoptosis induction cancer treatment. However, despite having high antitumor...
Nanoparticles based on the biocompatible amphiphilic poly(N-vinylpyrrolidone) (Amph-PVP) derivatives are promising for drug delivery. Amph-PVPs self-aggregate in aqueous solutions with formation of micellar nanoscaled structures. Amph-PVP nanoparticles able to immobilize therapeutic molecules under mild conditions. As is well known, many efforts have been made exploit DR5-dependent apoptosis induction cancer treatment. The aim study was fabricate Amph-PVP-based covalently conjugated...
Abstract The goal of the study was to estimate transfection efficacy and drug release in function PEG derivative cationic liposomes lipoplexes both 2D 3D vitro models as well a mouse model (in vivo). For this purpose, PEGylated nanocarriers based on OrnOrnGlu(C 16 H 33 ) 2 lipopeptides were fabricated characterized. loaded with DNA plasmid pGL3 or siRNA targeting 5′‐UTR region Hepatitis C virus, their efficacies studied by luciferase test PCR technique, respectively. pGL3‐lipoplexes...
Abstract Presently, most of anticancer drugs are high toxic for normal cells and, and as a result, they have severe side effects. Moreover, the formulations lipophilic poor selectivity. To overcome these limitations, various drug delivery systems could be proposed. The aim current study was to fabricate novel polysaccharide nanocontainers (NC) by one‐step ultrasonication technique evaluate their accumulation efficacy cytotoxicity in 2D (monolayer culture) 3D (tumor spheroids) vitro models....
TRAIL (TNF-related apoptosis-inducing ligand) and its derivatives are potentials for anticancer therapy due to the selective induction of apoptosis in tumor cells upon binding death receptors DR4 or DR5. Previously, we generated a DR5-selective mutant variant DR5-B overcoming receptor-dependent resistance TRAIL. In current study, improved antitumor activity by fusion with tumor-homing iRGD peptide, which is known enhance drug penetration into tissues. The obtained bispecific protein...
BACKGROUND: Nanocarriers based on biocompatible polymers are a promising delivery tool for biologically active substances and drugs, in particular antitumor agents. Curcumin, polyphenol, is known to possess pleiotropic therapeutic effects, including activity. The potential of curcumin has been shown various tumor types, ovarian adenocarcinoma. However, its lipophilic properties very low bioavailability limits use. Incorporating into nanocarriers enhances options expands as an agent. AIM: To...
Self-assembled nanoparticles based on amphiphilic poly(N-vinylpyrrolidone) (Amph-PVP) were proposed earlier as a new drug delivery system. In the current work, we study antitumor activity of Amph-PVP-based self-assembled polymeric micelles covalently conjugated with receptor-specific TRAIL variant DR5-B (P-DR5-B). The Amph-PVP polymer was synthesized by developed one-step technique (Kulikov et al., Polym. Sci. Ser. D, 2017). To stabilize associates, hydrophobic core loaded model substance...
The work is devoted to the preparation of a carbohydrate derivative lipotripeptide (N-lactitol-Gly)2-LysC16 irregular structure with two terminal residues D-galactose, branching link based on aliphatic L-lysine and its carbohydrate-free analog 1-pyrenbutanol as fluorescent label in hydrophobic fragment. developed synthesis scheme includes universal approaches peptide chemistry, well stages formation an acyclic lactose hydrophilic domain amphiphile. compounds are designed create compositions...
The development of technologies for effective targeted drug delivery oncotherapy requires the elaboration new methods to analyze features micro- and nanoscale distributions antitumor drugs in cells tissues. This paper presents a approach three-dimensional analysis intracellular distribution cytostatics using fluorescence scanning optical-probe nanotomography technology. Correlative nanostructure injected doxorubicin studied MCF-7 human breast adenocarcinoma made it possible reveal...
1. Trushina DB, Akasov RA, Khovankina AV, Borodina TN, Bukreeva TV, Markvicheva EA. Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro. Journal Molecular Liquids. 2019;284:215-224. doi:10.1016/j.molliq.2019.03.152 CrossRef Google Scholar