A5048153453- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Blood Coagulation and Thrombosis Mechanisms
- RNA modifications and cancer
- MicroRNA in disease regulation
- Kruppel-like factors research
- Systemic Lupus Erythematosus Research
- Venous Thromboembolism Diagnosis and Management
- Circular RNAs in diseases
- Bone health and treatments
- Metabolism and Genetic Disorders
- Chemical Reactions and Isotopes
- RNA Research and Splicing
- Antiplatelet Therapy and Cardiovascular Diseases
- Folate and B Vitamins Research
- Diagnosis and Treatment of Venous Diseases
- Pancreatitis Pathology and Treatment
- Healthcare Systems and Public Health
- Telomeres, Telomerase, and Senescence
- Heparin-Induced Thrombocytopenia and Thrombosis
- Eicosanoids and Hypertension Pharmacology
- Mesenchymal stem cell research
- Cerebrovascular and genetic disorders
- Atrial Fibrillation Management and Outcomes
- Sepsis Diagnosis and Treatment
Institute of Bioorganic Chemistry
2010-2025
Institute of Bioorganic Chemistry
2019
Russian Academy of Sciences
2006-2014
Abstract Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support GBM via paracrine signaling. Here we report that Endocan ( ESM1 ), an endothelial-secreted proteoglycan, confers enhanced proliferative, migratory, angiogenic properties regulates their spatial identity. Mechanistically, exerts at least part its functions direct binding activation the PDGFRA receptor. Subsequent...
The tumor suppressor PTEN controls multiple cellular functions, including cell cycle, apoptosis, senescence, transcription, and mRNA translation of numerous genes. In cells, is frequently inactivated by genetic mutations epimutations. aim this study was to investigate the methylation patterns gene its pseudogene PTENP1 as potential markers endometrial hyperplasia (EH) carcinoma (EC). Methylation 5'-terminal regions sequences studied using methyl-sensitive PCR genomic DNA isolated from 57...
The processed pseudogene PTENP1 is involved in the regulation of expression PTEN and acts as a tumor suppressor many types malignances. In our previous study we showed that methylation present not only tumor, but also normal endometrium tissues women over 45 years old. Here used methylation-specific PCR to analyze status CpG island located near promoter region malignant non-malignant collected from 236 different age groups. To confirm results, analyzed RNA sequencing microarray data 431 with...
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. One of reasons for resistance GBM to treatment extreme heterogeneity tumor and, in particular, presence cancer stem cells (CSCs) population glioblastoma cells. In this work, we investigated effect conditions that reduce proportion CSCs cell on levels long noncoding RNAs (lincROR and MALAT1) involved formation phenotype We have shown culturing under cause a decrease stemness (when fetal bovine serum added culture...
Aim. To develop a model for calculating the risk of venous thrombosis, taking into account presence known factors, comorbidity and congenital thrombophilia. Material methods . During study (2015 to 2017), 79 patients with thrombosis were examined (36 men 43 women, mean age — 56,76±15,570). The control group consisted 83 healthy volunteers without at moment in history (35 48 average 43,95±18,136). All individuals included analyzed G1691A mutations factor V gene, G20210A prothrombin C677T...
Among the many malignant neoplasms, glioblastoma (GBM) leads to one of worst prognosis for patients and has an almost 100% recurrence rate. The only chemotherapeutic drug that is widely used treating temozolomide, a DNA alkylating agent. Its impact, however, minor; it increases survival just by 12 14 months. Multiple highly selective compounds affect specific proteins have performed well in other types cancer proved ineffective against glioblastoma. Hence, there urgent need novel methods...
Glioblastoma (GBM) is considered one of the most aggressive human cancers. Earlier, our group have demonstrated that alternative RNA splicing plays an important role in regulation GBM phenotype. To continue this study, we analyzed type and expression levels spliceosomal genes a large number tumor tissue samples patient-derived sphere lines. We level factors allows dividing patients into groups with different survival prognosis also reflects phenotype tumor. In addition, identified events may...
ABSTRACT Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor. One of reasons for resistance MGB to treatment extreme heterogeneity tumor and, in particular, presence cancer stem cells (CSCs) population glioblastoma cells. In this work, we investigated effect conditions that reduce proportion CSCs GBM cell on levels long noncoding RNAs (lincROR and MALAT1) involved formation phenotype We have shown culturing under cause a decrease stemness (when fetal calf serum added...
Venous thromboembolism (VTE) is one of the common causes death in patients worldwide, but it can be prevented. The volume preventive measures depends on risks developing thrombosis. To assess this risk, there are many models VTE risk assessment (MRA). Not all include thrombophilia and concomitant diseases. We developed MRI, which takes into account factors for VTE, thrombophilia, estimated each specific disease, taking its duration. Our prognostic model allows us to improve a personalized...