A5002755280- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Cytomegalovirus and herpesvirus research
- vaccines and immunoinformatics approaches
- Thyroid Disorders and Treatments
- Advanced Biosensing Techniques and Applications
- Influenza Virus Research Studies
- Cancer, Hypoxia, and Metabolism
- Ovarian cancer diagnosis and treatment
- T-cell and B-cell Immunology
- Carbohydrate Chemistry and Synthesis
- Genetic Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Lipid metabolism and disorders
- Cancer Research and Treatments
- Autoimmune Neurological Disorders and Treatments
- Nanofabrication and Lithography Techniques
- Histone Deacetylase Inhibitors Research
Endocrinology Research Center
2022-2024
Engelhardt Institute of Molecular Biology
2007-2022
Ministry of Health of the Russian Federation
2022
National Medical Research Center of Cardiology
2021
Novosibirsk State University
2017
Lomonosov Moscow State University
2005-2016
Moscow State University
2011-2016
Immatics Biotechnologies (Germany)
2013
German Rheumatism Research Centre
2013
Nonalcoholic fatty liver disease (NAFLD) is a group of obesity-associated pathological changes characterized by abnormal accumulation lipids in cells the parenchyma. NAFLD and associated conditions, namely insulin resistance type II diabetes mellitus (DM2), as well possible risks developing fibrosis cirrhosis with potential outcome hepatocellular carcinoma, represent primary health problems developed countries, gradually replacing importance similar pathologies caused regular use hepatotoxic...
We report a method for edge enhancement in the images of transparent samples using analog image processing coherent light. The experimental technique is based on adaptive spatial filtering with an acousto-optic tunable filter telecentric optical system. demonstrate microscopic unstained and stained histological sections human thyroid tumor improved contrast.
A mutation in the hydin gene has been recently described as one possible mechanism leading to lethal congenital hydrocephalus mice, and a similar defect is proposed be involved an autosomal recessive form of human. Here, we report for first time on cancer association immunogenicity two HYDIN variants humans. One previously sequence derived from chromosome 1 copy, that is, KIAA1864. The second encoded by novel alternative transcript originating 16, which identified immunoscreening...
Tumors of the thyroid gland are extremely common. The incidence malignant neoplasms has increased rapidly in recent decades, although it is unclear whether this a true increase or result widespread use screening ultrasound. standard diagnostic procedure for determining risk malignancy and indications surgical treatment fine-needle aspiration biopsy followed by cytologic examination cellular aspirate. Despite fact that majority cases possible to make differential diagnosis between cancer...
Abstract Antibodies to cancer antigens can often be detected in the sera of patients, although mechanism underlying humoral immune response is poorly understood. Using immunoscreening tumor‐derived cDNA expression libraries (SEREX), we identified human histone deacetylase 3 (HDAC3) as serologically defined antigen colon cancer. Closely related HDAC1 and HDAC2 do not elicit patients. We show that C‐terminal region HDAC3 protein lacking homology other Class I HDAC contains at least distinct...
Adrenocortical cancer (ACC) is a rare endocrine malignancy of the adrenal cortex, which has an unfavorable prognosis and extremely aggressive clinical behavior in most cases. Nevertheless, cases more favorable disease course with late metastasis slow progression have been described. In 2017, International Agency for Research on Cancer (IARC) World Health Organization (WHO) 4th edition Classification Tumors Endocrine Organs identified histological variants ACC, such as classical, oncocytic,...
We established a peculiar structure of the O-specific polysaccharide (O-antigen) psychrotrophic strain Acinetobacter lwoffii, EK30A, isolated from 1.6–1.8 million-year-old Siberian permafrost subsoil sediment sample. The was released by mild acid degradation lipopolysaccharide and studied using chemical analyses, Smith degradation, 1H 13C NMR spectroscopy mass spectrometry. It found to contain D-homoserine, which is N-linked 4-amino-4,6-dideoxy-D-glucose (Qui4N) N-acylated itself with acetyl...
CD133 is an extensively studied marker of the most malignant tumor cell population, designated as cancer stem cells (CSCs). However, function this glycoprotein and its involvement in regulatory cascades are still poorly understood. Here we show a positive correlation between level plasma membrane expression proliferative activity Caco-2, HT-29, HUH7 lines. Despite substantial difference activities populations with different levels expression, transcriptomic proteomic profiling revealed only...
Current methods of preoperative diagnostics frequently fail to discriminate between benign and malignant thyroid neoplasms. In encapsulated follicular-patterned tumors (EnFPT), this discrimination is challenging even using histopathological analysis. Autoantibody response against tumor-associated antigens a well-documented phenomenon with prominent diagnostic potential; however, autoantigenicity remains poorly explored.Objectives were exploration antigen repertoire identification candidate...
Assay on a biochip provides simple and accurate procedure for the differential quantitation of SCCA1 SCCA2.
Parathyroid cancer (PС) is a rare malignant neoplasm of the endocrine system, characterized by severe course due to development life-threatening hypercalcemia. Despite relatively high survival rate, recurrence occurs about half time. The aggressive PС associated with both local spread process and distant metastasis. With exception isolated cases, cytotoxic chemo- radiotherapy are inefficacious, treatment protocols have not been developed. Therefore only effective way surgical removal...
Currently the "gold standard" in diagnostics of thyroid tumors is a fine-needle aspiration cytology (FNAC). However, FNAC cannot discriminate between benign and malignant 15 to 30% observations. In order develop an additional tool for differential we evaluated diagnostic performance 3-antigen serum autoantibody signature groups ( n = 22) 26) using dot-blot ELISA-based analysis The sensitivity specificity resultant array were estimated be 55–60% 95–100%, respectively p < 0.001 according...