A5020602048- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Immunotherapy and Immune Responses
- Scientific Research Methodologies and Applications
- Legal principles and applications
- Molecular Biology Techniques and Applications
- Healthcare Systems and Public Health
- Soil and Environmental Studies
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- Thyroid Disorders and Treatments
- Axon Guidance and Neuronal Signaling
- Law, Economics, and Judicial Systems
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Agriculture and Biological Studies
- Bladder and Urothelial Cancer Treatments
Repligen (United States)
2024
Addgene
2024
Endocrinology Research Center
2020-2023
Dnipro State Agrarian and Economic University
2023
P.A. Hertzen Moscow Oncology Research Institute
2021
Ministry of Health of the Russian Federation
2021
Faculdades Guarulhos
2018
Bukovinian State Medical University
2012
Currently, more than 2 billion people in the world suffer from thyroid dis eases, which develop as a result of iodine deficiency. The problem deficien cy remains relevant, both medical and social aspects since most residents Russian Federation live conditions Iodine deficiency has numerous negative consequences for development formation human body. In this regard, special attention should be paid to constant monitoring effectiveness preventive measures.
Adrenocortical cancer (ACC) is a rare endocrine malignancy of the adrenal cortex, which has an unfavorable prognosis and extremely aggressive clinical behavior in most cases. Nevertheless, cases more favorable disease course with late metastasis slow progression have been described. In 2017, International Agency for Research on Cancer (IARC) World Health Organization (WHO) 4th edition Classification Tumors Endocrine Organs identified histological variants ACC, such as classical, oncocytic,...
Abstract The paper considers one of the important problems water use – determination humidification conditions territory for hydromelioration needs. methodical approach to determining probability exceeding natural moisture by a group criteria is highlighted. Nowadays there no single, reliable and simple method this indicator. Assessing climatic conditions, considering their impact on crop productivity, it necessary take into account hydrometeorological factors that have decisive influence...
Adrenocortical cancer (ACC) is an orphan malignant tumor of the adrenal cortex with a predominantly poor prognosis and aggressive clinical course. Nowadays, mitotane non-alternative drug in treatment ACC. The search for prognostic parameters that determine sensitivity ACC to ongoing currently urgent task. Expression levels large subunit ribonucleotide reductase M1 (RRM1), cytochrome P450 2W1 (CYP2W1), sterol- O-acyltransferase-1 (SOAT1) are considered as potential predictors response...
Abstract Introduction: Sarcomatoid сlear cell renal carcinoma (ccRCC) represents a challenging and aggressive subset of kidney cancers with poor prognosis resistance to conventional treatments. Recent studies have shown the benefit checkpoint inhibitors (CPIs) for patients sarcomatoid components; therefore, precise objective evaluation differentiation is essential CPI selection. Here, we developed predictive model identify features in ccRCC. Methods: The machine learning-based transcriptomic...
1044 Background: The tumor microenvironment (TME) in invasive lobular carcinoma (ILC) has been shown to play a critical role progression and therapeutic response. However, dissecting the complexity heterogeneity of TME requires advanced profiling techniques that overcome limitations traditional histopathological methods. This study leverages single-cell spatial phenotyping using multiplex immunofluorescence (MxIF) integrated with RNA sequencing (RNA-seq) evaluate landscape ILC. Methods: MxIF...
2015 Background: Effective treatments for recurrent meningiomas following radiation therapy (RT) are limited. Inhibitors of the programmed-death-1 (PD-1) or programmed-death ligand-1 (PD-L1) pathway have shown modest activity these tumors in single-arm phase 2 studies. This study aims to evaluate immunological effects combining anti-PD-L1 (avelumab) with proton beam (PBT) radiation-relapsed meningiomas. Methods: Recurrent grade 1-3 that failed prior surgery and RT were treated neoadjuvant...
<h3>Background</h3> Single-cell spatial phenotyping using multiplex immunofluorescence (MxIF) imaging has emerged as a promising method to evaluate the heterogeneity of tumor microenvironment (TME) for immunotherapy response prediction. Here, we use our MxIF pipeline, based on an enhanced cell segmentation tool and analysis, TME immune landscape from whole slide images (WSIs) various cancers. <h3>Methods</h3> An machine-learning algorithm was trained validated datasets containing 96,765...
The analysis of the tumor microenvironment, especially tumor-infiltrated immune cells, is essential for predicting prognosis, clinical outcomes, and therapy strategies. Adrenocortical cancer a rare nonimmunogenic malignancy in which importance presence cells not well understood. In our study, we made first attempt to understand interplay between histology adrenocortical its landscape using cases from Cancer Genome Atlas database Endocrinology Research Centre collection (Moscow, Russia). We...
Despite the fact that pituitary adenomas are among most frequent brain tumours, TSH-secreting (thyrotropinomas) less than 1% of all adenomas. Due to increase in free fractions thyroid hormones at normal or elevated TSH levels, majority patients with these have a long anamnesis thyrotoxicosis which requires differential diagnosis pathology (Graves’ disease, toxic adenoma, autonomously functioning nodules). The thyrotropinoma is quite challenging for clinicians. This article describes case...
Thyroid disease, including autoimmune genesis, and diabetes mellitus are the two most common endocrine diseases in clinical practice. These pathologies have a mutual influence on each other. On one hand, thyroid hormones involved regulation of carbohydrate metabolism: excessive production is associated with hyperglycemia, while hypothyroidism has decreased level glucose by liver. other homeostasis disorder affects functional state gland: dystrophic, sclerotic atrophic processes developing...
Early and delayed consequences of ischemia-reperfusion the brain on state lipoperoxidation antioxidant protection in spleen control rats animals with diabetes mellitus were investigated. It has been shown that intensity decreases after 20 minutes ischemia following one hour reperfusion without diabetes, changes activity have not simple nature. Simultaneous activation occurs given period observation. On 12 th day enzymatic prevails over processes latter predominate diabetes.
The effect of incomplete global cerebral ischemia-reperfusion on the activity in pro-and anti-apoptotic processes thymocytes by intensity p53 and Bcl-2 protein expression was investigated. It has been shown that cortical zone rat thymus with four-month diabetes mellitus, as well control rats animals mellitus after ischemia-reperfusion, dominated. In medullary area gland diabetes, mechanisms either complicated or uncomplicated also predominated, but to a lesser extent than zone.
Acromegaly is a severe multifactorial neuroendocrine disease accompanied by increased secretion of growth hormone, which contributes to the active proliferation cells various tissues in body. Among complications disease, cardiovascular pathology predominates, and often cause mortality. Recently, however, with acromegaly, cases detection thyroid cancer are increasingly described. The causes increasing prevalence benign malignant neoplasms gland patients acromegaly much debate medical world....
Primary hyperparathyroidism (PHPT) is a significant endocrine disease caused by increased production of parathyroid hormone (PTH) altered glands and violation the mechanisms regulation serum calcium concentrations. These changes can lead to nephrolithiasis, osteoporosis, erosive ulcerative lesions gastrointestinal tract, number less specific symptoms (nausea, vomiting, weakness, fatigue, etc.). Etiologically, in more than 85% cases, PHPT consequence sporadic solitary adenoma or hyperplasia...
Solid pseudopapillary tumor of the pancreas is an extremely rare neoplasm exocrine portion this organ, which affects mostly young women and characterized by a low malignancy potential relatively benign clinical course. According to literature, even in disease progression as metastases, overall 5-year survival rate more than 95%. The paper describes case female patient with solid pancreatic regarded metastatic retroperitoneal space after surgical treatment previously performed 2001.Солидная...