A5030213270- Yeasts and Rust Fungi Studies
- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Forest Insect Ecology and Management
- Diabetes Treatment and Management
- Plant-Microbe Interactions and Immunity
- Genetic diversity and population structure
- Helicobacter pylori-related gastroenterology studies
- Plant Parasitism and Resistance
- Botany and Plant Ecology Studies
- Forest Ecology and Biodiversity Studies
- Agriculture and Biological Studies
- Bioeconomy and Sustainability Development
- Cancer Genomics and Diagnostics
- Veterinary medicine and infectious diseases
- Peptidase Inhibition and Analysis
- Genomics and Phylogenetic Studies
- Pancreatic function and diabetes
- Plant and Fungal Interactions Research
- Breast Cancer Treatment Studies
- Antibiotic Resistance in Bacteria
- Fungal Biology and Applications
- Nanoplatforms for cancer theranostics
- Glutathione Transferases and Polymorphisms
- Galectins and Cancer Biology
National Academy of Sciences of Belarus
2010-2024
Klogene (United States)
2024
Department of Biological Sciences
2023-2024
Addgene
2024
Gomel State Medical University
2008-2021
Vitebsk State Medical University
2021
Diabeteszentrum Bad Lauterberg
2013-2016
Siberian Federal University
2016
Abiotic stress significantly limits plant growth and production. Drought, in particular, is a severe constraint that affects agricultural productivity on global scale. Water induces plants set of morpho-anatomical (modification root leaf structure), physiological, biochemical (relative water content, membrane stability, photosynthesis, hormonal balance, antioxidant systems, osmolyte accumulation) changes mainly employed to cope with the drought stress. These strategies allow overcome...
Current breast cancer classification methods, particularly immunohistochemistry and PAM50, face challenges in accurately characterizing the HER2-low subtype, a therapeutically relevant entity with distinct biological features. This notable gap can lead to misclassification, resulting inappropriate treatment decisions suboptimal patient outcomes. Leveraging RNA-seq machine-learning algorithms, we developed Breast Cancer Classifier (BCC), unique transcriptomic classifier for more precise...
To determine whether the addition of sitagliptin to pre-existing therapy with liraglutide changes glycaemic excursions after a mixed meal.A total 16 patients type 2 diabetes treated metformin and (1.2 mg/d for ≥2 weeks) were randomized (sealed envelopes), within cross-over design, be studied on two occasions, an overnight fast, (1) (100 mg orally) (2) placebo (patients care givers blinded) administered 60 minutes before meal, or vice versa. Glucose (incremental area under curve [AUC];...
Salinity stress is among the key challenges for sustainable food production. It continuously increasing against backdrop of constant climate change and anthropogenic practices leading to a huge drop in soil, water, cultivated crop quality productivity. Halotolerant plants represent hot spots endophytic bacteria which may have mechanisms overcome salt stress. This research initiative aims highlight possible exploitation bacterial endophytes as microbial biotechnology tool productive success...
Aim To compare directly the clinical effects of vildagliptin and sitagliptin in patients with type 2 diabetes, a special emphasis on incretin hormones L ‐cell feedback inhibition induced by dipeptidyl peptidase ( DPP ‐4) inhibition. Methods A total 24 (12 diet/exercise regimen, 12 metformin) were treated, randomized order, for 7‐9 days, either (50 mg twice daily = 100 mg/d), (100 once those diet, 50 metformin treatment mg/d) or placebo (twice daily). mixed‐meal test was performed. Results...
Abstract This study was conducted to determine the parent–offspring genetic structure of pedunculate oak ( Quercus robur L.), sessile Q. petraea [Matt.] Liebl.) and their hybrids. Forty half-sib families maternal trees originating from one tree stand in southern Lithuania were analyzed using SSR RAPD markers. Based on a preliminary leaf morphological traits, individuals separated into six groups. The studied also compared for allelic diversity, including group variations; genotypic...
The growing importance of forest plantations increases the demand for phytopathogen resistant trees. This study describes an effective method early detection and identification main fungal phytopathogens in planting material silver birch (Betula pendula) downy (B. pubescens), based on estimation size internal transcribed spacers (ITS1 ITS2) 18S-5.8S-28S rDNA gene cluster, which are species-specific most micromycetes. electrophoretic assay ITS1 ITS2 loci has allowed us to identify predominant...
Curly birch [Betula pendula var. carelica (Merckl.) Hämet-Ahti] is a relatively rare variety of silver (B. Roth) that occurs mainly in Northern Europe and northwest part Russia (Karelia). It famous for the beautiful decorative texture wood. Abnormal xylogenesis underlying this trait heritable, but its genetic mechanism has not yet been fully understood. The high number potentially informative markers can be identified through sequencing nuclear organelle genomes. Here, de novo assembly,...
Частота бактериальных коинфекций среди пациентов с COVID-19 невелика, поэтому избыточное назначение антибиотиков может способствовать селекции резистентных штаммов энтеробактерий и грамотрицательных неферментирующих бактерий.Цель исследования -оценка локальных особенностей генетических механизмов антибиотикорезистентности K. pneumoniae на фоне пандемии инфекции COVID-19.Материал методы.Отобрано 37 устойчивых к карбапенемам pneumoniae, выделенных в 2016, 2017 2020 гг.от госпитализированных...
The sequencing and annotation of the curly birch chloroplast genome were carried out. A high level similarity structural functional organization cpDNA among species Betulaceae family was revealed. set primers developed to assess expression EST markers by real time PCR method.
Different pines species are heavily infected with fungal pathogens all over the world, some of them alien for European region. The potential invasion into forests, forest nurseries, urban greeneries causes great concern among Belarusian phytopathologists. In this regard, in recent years local scientists have been monitoring phytosanitary state natural and managed plantations to identify species. aim investigation was monitor conifers botanical dendrological gardens, tree nurseries Republic...
1044 Background: The tumor microenvironment (TME) in invasive lobular carcinoma (ILC) has been shown to play a critical role progression and therapeutic response. However, dissecting the complexity heterogeneity of TME requires advanced profiling techniques that overcome limitations traditional histopathological methods. This study leverages single-cell spatial phenotyping using multiplex immunofluorescence (MxIF) integrated with RNA sequencing (RNA-seq) evaluate landscape ILC. Methods: MxIF...
<h3>Background</h3> Single-cell spatial phenotyping using multiplex immunofluorescence (MxIF) imaging has emerged as a promising method to evaluate the heterogeneity of tumor microenvironment (TME) for immunotherapy response prediction. Here, we use our MxIF pipeline, based on an enhanced cell segmentation tool and analysis, TME immune landscape from whole slide images (WSIs) various cancers. <h3>Methods</h3> An machine-learning algorithm was trained validated datasets containing 96,765...
Seven microsatellite markers were used in molecular genetic analysis of curly birch and silver trunk tissue fragments produced through whip grafting or bark ring transplantation. The showed that whichever method was used, each component steadily retained their genotype upon fusion. It is demonstrated aberrant cells may be formed at the point fusion after donor transplantation, when all ascending descending transport pathways along recipient’s axis have been severed around circumference. Even...
An analysis of scientific publications and information materials on the main areas academic biological school activity is presented (for National Academy Sciences Belarus). The principles, structure system fundamental applied research design in field biology shown. obtained results, their implementation significance for various economy sectors are discussed. Promising innovative development science based interdisciplinary interaction have been identified.
Abstract Introduction: Although recent studies have shown that invasive lobular carcinoma (ILC) is associated with worse long-term outcomes compared to breast cancer of no special type (NST), they are treated in a similar manner. Therefore, classification approaches help understand the molecular characteristics different BC subtypes needed personalize therapy. Here, we describe an integrated analytical approach comprehensively characterize ILC samples. Methods: We collected genomic and...
Abstract Breast cancers (BCs) are segregable into subtypes based on their intrinsic molecular features. When evaluating HER2 status, clinicians often rely IHC, which is plagued by reproducibility issues. The widely used PAM50 transcriptomic system also does not include the HER2-low subtype. Addressing these limitations particularly important given recent approval of targeted therapy for BCs. Here, we developed a unique classification that can identify Accurate identification BCs help...
e13168 Background: Almost two decades ago, invasive breast cancer was classified into five subgroups based on expression patterns, each with distinct biological and prognostic characteristics. Advances in single-cell RNA sequencing offers insights the profiles of normal luminal epithelial cells. Here, we investigate connection between (BC) classification profiles. Methods: We applied data from recent studies (Table) to compile gene signatures corresponding cell clusters tissue. Normalized...
Mycobiomes of roots 1–2-year-old Pinus sylvestris L. and Picea abies (L.) Karst. plants in forest nurseries natural woods were studied using molecular genetic methods. Biodiversity indicators established (species abundance, dominance index, Shannon diversity index) comparative characteristics the mycobiomes provided. It was revealed that main species complexes mycorrhizae juvenile pine spruce formed by a similar list fungal from genera Wilcoxina , Phialocephala Helotiaceae etc. At same time,...