A5040753808- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Diabetes and associated disorders
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Diabetes Treatment and Management
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Sexual Differentiation and Disorders
- Myasthenia Gravis and Thymoma
- Parathyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Lymphoma Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Pancreatic and Hepatic Oncology Research
- Eating Disorders and Behaviors
University of Coimbra
2018-2025
Hospital Braga
2013-2024
Hospitais da Universidade de Coimbra
2015-2024
University of Minho
2023
Diabetes Australia
2017
Addison's disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it even rarer. We report the case of 30-year-old pregnant patient with referred to Obstetrics-Endocrinology specialty consult at 14 weeks gestation. She had been emergency department her local hospital various times during first trimester presenting clinical scenario suggestive glucocorticoid under-replacement (nausea, persistent vomiting and hypotension),...
Objective: To evaluate glycemic control according to the number of daily basal rates (BRs) in type 1 diabetes patients using continuous subcutaneous insulin infusion (CSII). Subjects and methods: Cross-sectional study treated with an open-loop CSII for at least 6 months a flash glucose monitoring system. Patients were divided into 2 groups: group (G1) (G2), ≤4 >4 BRs/24h, respectively. The groups compared regarding HbA1c, time range (TIR), [...]
Summary Familial hypomagnesemia with secondary hypocalcemia (FHSH) is a rare autosomal recessive disorder (OMIM# 602014) characterized by profound associated hypocalcemia. It caused mutations in the gene encoding transient receptor potential cation channel member 6 (TRPM6). usually presents neurological symptoms first months of life. We report case neonate presenting recurrent seizures and severe hypomagnesemia. The genetic testing revealed novel variant TRPM6 gene. patient has been treated...
Although it is a rare entity, primary lymphoma of the adrenal gland should be considered in differential diagnosis bilateral nodular lesions, particularly when there evidence associated insufficiency. We describe case an 83-year-old woman admitted to emergency department due month's history asthenia, weight loss, anorexia and nausea. Abdominopelvic CT showed lesions glands stimulation test with tetracosactide was compatible CT-guided biopsy left performed, histopathological results were...
Summary Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders related to enzyme deficiencies in the steroidogenesis pathway leading impaired corticosteroid biosynthesis. Depending on extension defect, there may be variable severities CAH – classic and non-classic. We report case 37-year-old male patient with previously unknown diagnosis referred Endocrinology evaluation due class III obesity insulin resistance. A high diagnostic suspicion was raised at first...
Hyperreninemic hypoaldosteronism due to aldosterone synthase (AS) deficiency is a rare condition typically presenting as salt-wasting syndrome in the neonatal period. A one-month-old Portuguese boy born non-consanguineous parents was examined for feeding difficulties and poor weight gain. laboratory workup revealed severe hyponatremia, hyperkaliaemia high plasma renin with unappropriated normal levels, raising suspicion of AS deficiency. Genetic analysis showed double homozygous two...
Insulinomas are the most frequent cause of hyperinsulinaemic hypoglycaemia. Although surgical enucleation is standard treatment, a few other options available to high-risk patients who elderly or present with co-morbidities. We case report an 89-year-old female patient was admitted emergency department due recurrent hypoglycaemia, especially during fasting. Laboratory work-up raised suspicion and abdominal CT scan revealed 12 mm nodular hypervascular lesion pancreatic body suggestive...
Diagnosis of Cushing's syndrome remains a challenge in clinical endocrinology. Even though late-night salivary cortisol is used as screening tool, individualized cut-off levels for each population must be defined.Three groups subjects were studied: normal subjects, suspected and proven syndrome. Salivary was measured using an automated electrochemiluminescence assay. The functional sensitivity the assay 0.018 μg/dL. diagnostic level defined by Receiver Operating Characteristic curve Youden's...
We report a case of woman with diagnosis breast cancer who unintentionally started gaining weight, feeling tired, and constipated 44 weeks after the initiation trastuzumab. Hypothyroidism secondary to an autoimmune thyroiditis associated trastuzumab was diagnosed, first described in Portugal fourth worldwide. Our intention regarding publication this is alert clinicians treating people that they should ask patients about symptoms hypothyroidism screen thyroid function before, during,...
Hypoglycemia leading to hospitalization is associated with adverse economic outcomes, although the real burden unknown. The HIPOS-WARD (Hypoglycemia In Portugal Observational Study-Ward) aimed characterize ward admissions due hypoglycemia episodes in treated patients diabetes and assess their impact National Health System. Observational, cross-sectional study, conducted 16 Portuguese centers for 22 months. applied microcosting approach was based on healthcare resource data, collected from...
Abstract Background We intended to estimate the proportion hypoglycemic/hyperglycemic emergency episodes in treated diabetes mellitus (DM) patients admitted a hospital ward, and calculate prevalence of risk factors for hypoglycemia diabetic complications. Methods In this cross-sectional, multicentered study, observational data was collected by physicians from patient’s hospitalization discharge/death. Statistical tests were 2-tailed considering 5% significance level. Results There 646 ward...
Summary Hypoparathyroidism is characterized by low or inappropriately normal parathormone production, hypocalcemia and hyperphosphatemia. Autosomal dominant (ADH) type 1 one of the genetic etiologies hypoparathyroidism caused heterozygous activating mutations in calcium-sensing receptor ( CASR ) gene. Current treatments for ADH include supplementation with calcium active vitamin D. We report a case an adolescent affected syncope without prodrome. The testing revealed variant Due to standard...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
This study aimed to evaluate the association of detectable C-peptide levels with various continuous glucose monitoring (CGM) metrics and diabetes complications in patients type 1 mellitus (T1DM).
Cutaneous small vessel vasculitis is a severe neutrophilic vascular inflammation mediated by immune complexes that involves the dermal postcapillary venules. Neoplasms represent 2-5% of all causes secondary cutaneous vasculitis. We present case 52-year-old man who was admitted due to 10-day history respiratory symptoms and myalgia. From third day onwards, patient noticed appearance lesions in lower limbs with palpable purpura erythematous papules. Additionally, he reported asthenia, anorexia...