A5015493702- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Diabetes and associated disorders
- Diabetes Management and Research
- Thyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Growth Hormone and Insulin-like Growth Factors
- Thyroid and Parathyroid Surgery
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- BRCA gene mutations in cancer
- Oral microbiology and periodontitis research
- Glioma Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Head and Neck Anomalies
- Eating Disorders and Behaviors
- Myasthenia Gravis and Thymoma
Centro Universitário São Camilo
2024
Hospitais da Universidade de Coimbra
2008-2019
University of Coimbra
2008-2019
Diabetes Australia
2012-2019
Sociedade Portuguesa de Cardiologia
2006-2016
Society for Endocrinology
2013
Instituto Nacional de Saúde
2011
National Institute of Health Dr. Ricardo Jorge
2011
American Thyroid Association
2006
Centro Hospitalar Lisboa Norte
1993
Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent aggressive cancers. We aimed evaluate the frequency of TERT lesions investigate prognostic significance such a large cohort patients with differentiated (DTCs). This was retrospective observational study. studied 647 tumors tumor-like lesions. A total 469 FCDTC treated followed five university hospitals included. Mean follow-up (±SD) 7.8 ± 5.8...
Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with primary tumor genotype.To evaluate TERT promoter (TERTp), BRAF, NRAS metastatic carcinomas, analyzing tumors, lymph node (LNMs), distant metastases.Mutation analysis was performed 437 tissue samples from 204 patients, mainly papillary carcinomas (PTCs; n = 180), including 196 LNMs 56 metastases. All included corresponded to radioiodine-refractory tissue.We found following mutation...
Type 2 diabetes (T2DM) patients develop vascular complications and have increased risk for neurophysiological impairment. Vascular pathophysiology may alter the blood flow regulation in cerebral microvasculature, affecting neurovascular coupling. Reduced fMRI signal can result from decreased neuronal activation or disrupted The uncertainty about pathophysiological mechanisms (neurodegenerative, vascular, both) underlying brain function impairments remains. In this cross-sectional study, we...
Iodine is the key element for thyroid hormone synthesis, and its deficiency, even moderate, harmful in pregnancy, when needs are increased, because of potential deleterious effects on fetal brain development. In Portugal, no recent data iodine intake exists. The objective this countrywide study was to analyze status pregnant Portuguese women order propose adequate measures health authorities.Using a fast colorimetric method, urine concentration (UIC) evaluated 3631 followed 17 maternity...
Thyroglobulin (Tg) levels measured at the time of remnant ablation after thyroid hormone withdrawal (THW) were shown to have prognostic value in predicting disease-free status.Our objectives determine whether stimulated Tg levels, performed under recombinant human TSH (rhTSH) stimulation, has absence detectable disease 1 year radioiodine therapy and compare results obtained with this approach a cohort patients submitted THW.This was prospective observational study.The study included 293...
A vitamina D é única entre as vitaminas, pois funciona como uma hormona e pode ser sintetizada na pele a partir da exposição à luz solar. Além dos seus efeitos no metabolismo fosfocálcico, evidências recentes correlacionam níveis insuficientes de com um risco aumentado desenvolvimento outras patologias não ósseas. O nível sérico 25-hidroxivitamina (25(OH)D) o melhor indicador do conteúdo corporal ao refletir obtida ingestão alimentar solar, bem conversão depósitos adiposos fígado. Os 25(OH)D...
Objectives Since most of the studies evaluates diabetics on multiple daily injections therapy and continuous subcutaneous insulin infusion may help gain better metabolic control prevent complications, objective this study was to evaluate prevalence dental caries, unstimulated salivary flow rate total bacteria load, Streptococcus spp. levels Lactobacillus in saliva supragingival biofilm type 1 pump. Material Methods Sixty patients with diabetes pump 60 nondiabetic individuals were included....
Introdução: A diabetes mellitus é uma doença endócrina onde estão envolvidas as hormonas produzidas pelos ilhéus de Langerhans. pode afetar várias funções do sistema imunitário indivíduo, predispondo-o para a inflamação crónica, degradação progressiva dos tecidos e diminuição da reparação tecidular. Das alterações provocadas por esta ao nível cavidade oralpode-se destacar xerostomia, disgeusia, periodontais, aumento suscetibilidade à infeção tanto polpa dentária como nos...
Summary CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this is not strongly diabetes in Portuguese population.
Early diagnosis is crucial in Diabetic Retinopathy (DR), to avoid further complications. The disease can be classified into one of two stages (an early stage non-proliferative and a later proliferative diabetic retinopathy), diagnosed based on existence quantity characteristic set lesions, such as micro-aneurysms, hemorrhages or exudates, Eye Fundus Images (EFI). It therefore important segment adequately regions potential highlight classify the lesions degree DR. Density clustering methods...
Background Adrenal insufficiency (AI) is a life-threatening disease characterized by deficient production of glucocorticoids and/or mineralocorticoids. It caused primary or secondary/tertiary adrenal failure. Prompt diagnosis and management are essential may even be life-saving. Methods We retrospectively collected clinical, laboratory radiological data from AI patients observed over 34 years (1984-2017) in pediatric endocrinology department tertiary care hospital. Results Seventy were...
Addison's disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it even rarer. We report the case of 30-year-old pregnant patient with referred to Obstetrics-Endocrinology specialty consult at 14 weeks gestation. She had been emergency department her local hospital various times during first trimester presenting clinical scenario suggestive glucocorticoid under-replacement (nausea, persistent vomiting and hypotension),...
Addison's disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication syndrome. It caused by adrenal venous thrombosis and consequent hemorrhagic infarction or spontaneous (without thrombosis) hemorrhage, usually occurring after surgery anticoagulant therapy. We present clinical case 36-year-old female patient with previous diagnosis APS. She presented multiple thrombotic events, including abortions. During evaluation...
Summary Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis scarce. We present a clinical case of male patient 25 years with an intracranial germinoma and 16p11.2 microdeletion. His initial complaints were related to obesity, loss facial hair polydipsia. He also had history social-interaction difficulties during childhood. blood tests consistent hypogonadotropic hypogonadism secondary adrenal insufficiency, he been...
Xenobiotic-metabolizing enzymes are widely polymorphic and confer interindividual variation in the ability to detoxify carcinogens or activate pro-carcinogens. A common polymorphism of cytochrome P450 2D6 (CYP2D6) results lack enzyme activity has been associated with an altered susceptibility several cancers. The aim this study was investigate association between CYP2D6 poor metaboliser genotype risk papillary thyroid cancer (PTC).Retrospective case-control study.One hundred eighty-seven...