A5087539779- Plant Toxicity and Pharmacological Properties
- Recycling and Waste Management Techniques
- MicroRNA in disease regulation
- Polymer composites and self-healing
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Essential Oils and Antimicrobial Activity
- NF-κB Signaling Pathways
- Insect Pest Control Strategies
- Sesquiterpenes and Asteraceae Studies
- Polysaccharides Composition and Applications
- Toxin Mechanisms and Immunotoxins
- Pesticide Residue Analysis and Safety
- Analytical chemistry methods development
- Molecular Biology Techniques and Applications
- Phytochemicals and Antioxidant Activities
- Lignin and Wood Chemistry
- Mycotoxins in Agriculture and Food
- Natural product bioactivities and synthesis
- Plant Surface Properties and Treatments
- Phytochemistry and Biological Activities
- Extraction and Separation Processes
- Insect and Pesticide Research
- Cytokine Signaling Pathways and Interactions
Universidade do Porto
2015-2024
João Pinheiro Foundation
2023
Faculty (United Kingdom)
2018-2021
Engineering (Italy)
2018-2021
Instituto Português de Oncologia Francisco Gentil
2019
IPO Porto
2019
Universidad de La Laguna
2001
Universidade de São Paulo
1991
Natural cork stopper manufacturing produces a significant amount of waste, which is granulated and combined with synthetic glues for use in wide range applications. There high demand using biosourced polymers these composite materials. In this study, xanthan gum (XG) chitosan (CS) were investigated as possible natural binders cork. Xanthan was oxidized at two different aldehyde contents strategy to improve its water resistance. This modification studied detail by 1H 13C nuclear magnetic...
O presente paper almeja proceder a uma releitura das teses dworkinianas à luz da obra de Menelick Carvalho Netto, modo melhor compreender exata dimensão transformações que Dworkin opera no campo teoria do direito (e, sobretudo, Constituição) e assim lançar as bases teoréticas para se possa apreciação crítica recepção Netto. Após breve introdução, divergência entre os autores ditos neopositivistas acerca discricionariedade judicial será utilizada mote apresentar particular leitura faz Netto...
Este paper registra comunicação oral proferida pelos autores durante o X Congresso da Associação Brasileira de Pesquisadores em Sociologia do Direito (ABraSD). Na ocasião, foi apresentado esboço inicial disciplina preparação a respeito surgimento ideia moderna Constituição. Em linhas gerais, almeja-se aferir que forma – e termos se deu recuperação conceito Constituição sua ressignificação ao longo experiência modernidade. A apresenta como aquisição evolutiva modernidade, nela encontrou um...
ABSTRACT: A new methodology to the quantification of ethyl carbamate (EC) has been developed. This method allows analysis by HPLC in samples wine, fortified and wine brandy, a pre‐column derivatization with 9‐xanthydrol, fluorescence detection. does not require previous sample extraction or concentration. The presents an average recovery 96% among studied, detection limit 4.2μg/L, intermediate precision 6.3%. comparison results obtained for EC on same brandy GC/MS are statistically...
Human Papillomavirus cause a number of diseases most notably cervical cancer. K14-HPV16 transgenic mice expressing the HPV16 early genes in squamous epithelial cells provide suitable experimental model for studying these diseases. MicroRNAs are small non-coding RNAs that play an important role regulating gene expression and have been suggested to cancer development. The miR-155 remains controversial there is limited evidence linking this miRNA HPV- associated We hypothesized modulates each...
Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on expression COX2 and tumor-associated inflammation human papillomavirus type 16 (HPV16)-transgenic mice. Materials Methods: Six-week-old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16<sup>−/−</sup> no treatment, n=12; HPV16<sup>+/−</sup> n=13; rutin, curcumin, n=13. HPV16-induced skin lesions their inflammatory infiltrates studied...
Abstract Head and neck squamous cell carcinomas (HNSCCs) associated with human papillomavirus (HPV) occur specifically in the tonsils tongue base, but reasons for this specificity remain unknown. We studied distribution of oral pharyngeal lesions HPV16‐transgenic mice where expression all HPV16 early genes is targeted to keratinising epithelia by cytokeratin 14 ( Krt14 ) gene promoter. At 30 weeks age, 100% developed low‐ high‐grade intraepithelial dysplasia at multiple sites. Twenty per...
Abstract Penile cancer is an under‐studied disease that occurs more commonly in developing countries and 30–50% of cases show high‐risk human papillomavirus (HPV) infection. Therapeutic advances are slow, largely due to the absence animal models for translational research. Here, we report first mouse model HPV‐related penile cancer. Ten‐week‐old mice expressing all HPV16 early genes under control cytokeratin 14 ( Krt14 ) gene promoter matched wild‐type controls were exposed topically...
Essential oils are natural compounds used by humans for scientific purposes due to their wide range of properties. Eugenol is mostly present in clove oil, while pulegone the main constituent pennyroyal oil. To guarantee safe use eugenol and both animals, this study addressed, first time, effects these compounds, at low doses (chronic toxicity) high (acute toxicity), laboratory animals. Thirty-five FVB/n female mice were randomly assigned seven groups (n = 5): group I (control, non-additive...
The indiscriminate use of biocides for general disinfection has contributed to the increased incidence antimicrobial tolerant microorganisms. This study aims assess potential seven phytochemicals (tyrosol, caffeic acid, ferulic cinnamaldehyde, coumaric cinnamic acid and eugenol) in control planktonic sessile cells Staphylococcus aureus Escherichia coli. Cinnamaldehyde eugenol showed properties, minimum inhibitory concentrations 3-5 5-12 mM bactericidal 10-12 10-14 against S. E. coli,...
Agricultural activity relays deeply on the usage of synthetic insecticides for pest control, however, extensive use or misuse these substances can have negative impacts environment, human health and even agricultural ecological subsystems. Essential oils (EOs) are secondary metabolites synthesized in plant secretory structures that less hazardous to environment safer handle, with known effectivity against arthropods, thus presenting a viable eco-friendly alternative typical insecticides....
A novel pathway of molinate mineralization promoted by a defined mixed culture composed five bacteria (named ON1 to ON5) was proposed previously. Evidence obtained metabolic association between Gulosibacter molinativorax ON4(T), capable breakdown, and the remaining bacteria. In present study, role each isolate in that further explored possible synergistic effect all bacterial isolates for stability is discussed. The cleavage thioester bond, whether occurring under aerobic or anaerobic...
This study presents a new technological approach to minimize the use of antimicrobial (AMB) agents and their deleterious effects, based on principle drug-delivery systems whereby AMB chemicals are transported microparticles. The efficacy microparticles carrying quaternary ammonium compound (QAC), benzyldimethyldodecyl chloride (BDMDAC), was assessed against Pseudomonas fluorescens in both planktonic biofilm state. were prepared using layer-by-layer (LBL) self-assembly technique. Oppositely...