A5100749135- Reproductive Health and Technologies
- Animal Behavior and Welfare Studies
- Agriculture Sustainability and Environmental Impact
- Cervical Cancer and HPV Research
- Dialysis and Renal Disease Management
- Human-Animal Interaction Studies
- Multiple Myeloma Research and Treatments
- dental development and anomalies
- Reproductive Biology and Fertility
- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Oral Health Pathology and Treatment
- Personality Disorders and Psychopathology
- Bone and Dental Protein Studies
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Acute Kidney Injury Research
- Therapeutic Uses of Natural Elements
- Body Image and Dysmorphia Studies
- Thyroid and Parathyroid Surgery
- Cancer Cells and Metastasis
- Genetic Syndromes and Imprinting
Hospitais da Universidade de Coimbra
2012-2025
Centro Hospitalar de Vila Nova de Gaia
2023-2024
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2023
Real Hospital Português
2023
Universidade do Porto
2016-2022
Communities In Schools of Orange County
2022
New York Proton Center
2022
Manhattan Institute for Policy Research
2022
Oregon Medical Research Center
2022
Lindsay Unified School District
2022
Breast cancer is a heterogeneous malignant disease with varying prognosis and classified into four molecular subtypes. It remains one of the most prevalent cancers globally, tumor microenvironment playing critical role in progression patient outcomes. This study evaluated samples from 40 female patients luminal A B breast cancer, utilizing flow cytometry to phenotypically characterize immune cells present within tissue. The B-like exhibited increased infiltration CD4+ cells, regulatory T...
In 1986, European Directive 86/609/EEC, regulating the use of animals in research, was one first examples common legislation to set standards for animal protection across Member States former Economic Community, now Union, with aim securing a level playing field. Starting 2002, process revising experimentation undertaken, its key aims being ensure high welfare laboratory Europe. This resulted 2010/63/EU, which has regulated this activity Europe since 2013. Since is Union Directive,...
We compared two consensus primer PCR human papillomavirus (HPV) genotyping methods for the detection of individual HPV genotypes and carcinogenic as a group, using stratified sample enrollment cervical specimens from sexually active women participating in NCI/Costa Rica HPV16/18 Vaccine Efficacy Trial. For SPF(10) method, DNA was extracted 0.1% specimen by MagNA Pure LC instrument, 65-bp region L1 gene targeted amplification primers, 25 were detected reverse-line blot hybridization...
The objective of this analysis was to compare the performance characteristics two human papillomavirus (HPV) DNA detections assays, Hybrid Capture 2 assay (HC2) and SPF(10) assay, for detection carcinogenic HPV. Data are from enrollment visits women who participated in randomized, double-blind, placebo-controlled phase III HPV16/18 Vaccine Trial Guanacaste, Costa Rica. We compared results HC2 testing cervical specimens. Since line probe (LiPA) system does not distinguish between HPV type 68...
Background. Little is known about the epidemiology of oral human papillomavirus (HPV) in Latin America. Methods. Women (N = 5838) aged 22–29 control and vaccine arms an HPV-16/18 trial Costa Rica had oral, cervical, anal specimens collected. Samples were tested for alpha mucosal HPV types (SPF10/LiPA25 version 1); a subset samples (n 500) was cutaneous genera alpha, beta, gamma, mu, nu. Results. In arm 2926), 1.9% women detected, 1.3% carcinogenic HPV, 0.4% HPV-16; similar patterns non-16/18...
Amelogenesis imperfecta (AI) is a heterogeneous group of genetic conditions that result in defective dental enamel formation. Amelotin (AMTN) secreted protein thought to act as promoter matrix mineralization the final stage development, and strongly expressed, almost exclusively, maturation ameloblasts. Amtn overexpression knockout mouse models have with no other associated phenotypes, highlighting AMTN an excellent candidate gene for human AI. However, mutations yet been Using whole exome...
Introduction In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant cells disrupts normal homeostasis interactions between T cells, leading to immune dysregulation. CD20+ are a subpopulation that appear be involved in autoimmune diseases cancer. Methods Here, we quantified phenotypically characterized from MBL subjects CLL patients using flow cytometry correlated our findings with B-cell receptor mutational status other features disease....
<i>Background/Aim:</i> The determinants of baseline fast solute transport are still unclear. We prospectively investigated the relationship peritoneal with markers inflammation, angiogenesis, and membrane status, a focus on transporters. <i>Methods:</i> Seventy-one incident dialysis patients were assessed annual equilibration tests, using 3.86% glucose solution. Residual renal function including systemic intraperitoneal interleukin-6 (IL-6), effluent cancer antigen...
Abstract Head and neck squamous cell carcinomas (HNSCCs) associated with human papillomavirus (HPV) occur specifically in the tonsils tongue base, but reasons for this specificity remain unknown. We studied distribution of oral pharyngeal lesions HPV16‐transgenic mice where expression all HPV16 early genes is targeted to keratinising epithelia by cytokeratin 14 ( Krt14 ) gene promoter. At 30 weeks age, 100% developed low‐ high‐grade intraepithelial dysplasia at multiple sites. Twenty per...
Uremia has been implicated in increased oxidative stress (OS) and decreased monocyte HLA-DR expression chronic kidney disease (CKD) patients. Thus, one would expect normalization of these parameters after successful transplant (KTx). Our aim was to describe patterns OS KTx explore the effect renal function different immunosuppression regimens. 30 patients (20 male; 48 +/- 11 years) were enrolled compared with 20 healthy controls. We measured advanced oxidation protein products (AOPP)...
<i>Background/Aims:</i> Establishment of reference values for small solute transport, sodium sieving and effluent CA125 with 3.86% (4 h) peritoneal equilibration test (PET), comparison fast-fast PET regard to transport categories. <i>Methods:</i> Cross-sectional study; 69 prevalent patients. Sodium corrected diffusion a formula applicable the PET. appearance rate (AR) was measured. Expected observed 60 min D/P<sub>creatinine</sub> were compared by Bland...
A crescente evidência da possibilidade de desempenhos enganosos ou fraudulentos em contexto exame neuropsicológico forense, incluindo casos envolvendo adultos idosos (por exemplo, determinação incapacidade pedidos reforma antecipada), torna imperativa a inclusão medidas específicas simulação e esforço insuficiente nos protocolos avaliação. O Rey 15-Item Memory Test (15-IMT) é um dos testes mais utilizados neste âmbito. Contudo, apesar se reconhecer que o efeito tecto subjacente ao...
Vδ1+ T cells, a subset of γδ are responsible for innate-like immune responses. Recently, an anti-tumor function mediated by MHC-unrestricted recognition lipid and stress molecules, has also been described in these cells. This study aimed to quantify phenotypically characterize circulating cells B cell Chronic Lymphocytic Leukemia (CLL) Monoclonal lymphocytosis (MBL).This enrolled 58 individuals distributed five groups: Binet C CLL (n = 9), A 26), High count-MBL 10), Low 5), control group 8)....
A escassez de pessoal em instituições saúde é uma preocupação crescente, refletida na elevada percentagem dias sedentários entre adultos mais velhos. Conhecendo os benefícios da atividade física e cognitiva para a qualidade vida, plataforma Actif surge como solução inovadora enfrentar esse desafio. Assim, propusemos avaliar implementação ERPI ASAS TAP durante um mês, comparando-o com o mês anterior, analisando seus benefícios. análise comparativa dois períodos estudo revelou aumento 21% no...
Oxidative stress (OS) and monocyte HLA-DR expression are known to be predictive of mortality in sepsis; nevertheless, limited information exists regarding sepsis with acute kidney injury (AKI). The aim the study was correlate these markers outcome septic patients AKI requiring continuous renal replacement therapy (CRRT). Advanced oxidation protein products (AOPP) were measured 32 on days 1, 3, 7, 14, 21, 28. In 14 we assessed percentage monocytes expressing (%DR+) mean fluorescence intensity...
Objectives. Hungry bone syndrome (HBS) is a severe and underdiagnosed complication of parathyroidectomy in the treatment primary hyperparathyroidism (PHP) secondary hyper-parathyroidism to chronic kidney disease (SHP-CKD).Methods. A longitudinal study was conducted compare postoperative outcomes patients who developed HBS two different time frames: before after implementing protocol with an intensive electrolytic monitoring algorithm regarding supplementation.Results. Overall, 77...
Awareness of the discussion surrounding social and ethical challenges regarding gamete donation is crucial for good governance assisted reproduction techniques. In this article, we analyze topics that guided debate in Portuguese ethics organizations, discussing their connections with themes addressed internationally. To end, March 2018, systematically searched websites National Council Medically Assisted Procreation Ethics Life Sciences. We carried out a thematic content analysis 25...
Amelogenesis imperfecta (AI) describes a heterogeneous group of developmental enamel defects that typically have Mendelian inheritance. Exome sequencing 10 families with recessive hypomaturation AI revealed four novel and one known variants in the matrix metallopeptidase 20 (MMP20) gene were predicted to be pathogenic. MMP20 encodes protease cleaves developing extracellular is necessary for normal crystal growth during amelogenesis. New homozygous missense changes shared between Pakistani...
Drawing on the views of donors and recipients about anonymity in a country that is experiencing transition towards non-anonymous gamete donation mandated by Constitutional Court, we explore how intersection between rights-based approaches an empirical framework enhances recommendations for ethical policy healthcare. Between July 2017 April 2018, 69 147 recipients, recruited at Portuguese Public Bank Gametes, participated this cross-sectional study. Position was assessed through open-ended...
se ha reportado mediastinitis hasta en 4% de los pacientes que someten a revascularización miocárdica, con una mortalidad cercana al 25%. Es complicación potencialmente letal, etiología multifactorial, influye la calidad vida y el pronóstico del paciente, que, asimismo, genera un elevado costo derivado su atención. Hasta 25% informado infección safenectomía, morbilidad asociada elevada. determinar porcentaje tasas sitio operatorio superficial profundo después cirugía miocárdica operados...