A5039024736- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Genital Health and Disease
- Cancer-related molecular mechanisms research
- Cleft Lip and Palate Research
- Urological Disorders and Treatments
- MicroRNA in disease regulation
- Spaceflight effects on biology
- Toxin Mechanisms and Immunotoxins
- GDF15 and Related Biomarkers
- Ovarian cancer diagnosis and treatment
- Nutrition and Health in Aging
- Circular RNAs in diseases
- Medical and Biological Ozone Research
- Air Quality and Health Impacts
University of Trás-os-Montes and Alto Douro
2018-2022
Abstract Head and neck squamous cell carcinomas (HNSCCs) associated with human papillomavirus (HPV) occur specifically in the tonsils tongue base, but reasons for this specificity remain unknown. We studied distribution of oral pharyngeal lesions HPV16‐transgenic mice where expression all HPV16 early genes is targeted to keratinising epithelia by cytokeratin 14 ( Krt14 ) gene promoter. At 30 weeks age, 100% developed low‐ high‐grade intraepithelial dysplasia at multiple sites. Twenty per...
Abstract Penile cancer is an under‐studied disease that occurs more commonly in developing countries and 30–50% of cases show high‐risk human papillomavirus (HPV) infection. Therapeutic advances are slow, largely due to the absence animal models for translational research. Here, we report first mouse model HPV‐related penile cancer. Ten‐week‐old mice expressing all HPV16 early genes under control cytokeratin 14 ( Krt14 ) gene promoter matched wild‐type controls were exposed topically...
Cancers induced by HPV remain a significant public health threat, fueling the study of new therapies.
Cancer cachexia is a multifactorial syndrome characterized by general inflammation, weight loss and muscle wasting, partly mediated ubiquitin ligases such as atrogin-1, encoded Fbxo32. Cancers induced high-risk human papillomavirus (HPV) include anogenital cancers some head-and-neck are often associated with cachexia. The aim of this study was to assess the presence cancer in HPV16-transgenic mice or without exposure chemical carcinogen 7,12-dimethylbenz(a)anthracene (DMBA). Male expressing...
To evaluate the expression of lincRNA-p21, H19, EMX2OS, SNHG12 and MALAT1 in a mouse model human papillomavirus 16 (HPV16)-induced carcinogenesis cachexia.Chest skin, ear, tongue, penis gastrocnemius muscle samples from wild-type mice (HPV-) K14-HPV16 male (HPV+) were collected to selected lncRNAs using real-time PCR (qPCR).In chest skin SNHG12, EMX2OS lincRNA-p21 down-regulated HPV+ versus HPV- mice. In tongue penile tissues, there was only down-regulation Additionally, tissue, decreased...
A growing proportion of oropharyngeal squamous cell carcinomas (OPSCC) are associated with infection by high-risk human papillomavirus (HPV). For reasons that remain largely unknown, HPV+OPSCC is significantly more common in men than women. This study aims to determine the incidence OPSCC male and female HPV16-transgenic mice explore role sex hormone receptors sexual predisposition for HPV+ OPSCC. The tongues 30-weeks-old (n = 80) 90) matched wild-type 10) FVB/n were screened histologically...