A5058630619- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Gut microbiota and health
- Protein Kinase Regulation and GTPase Signaling
- Digestive system and related health
- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
- Protein Structure and Dynamics
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Biochemical Analysis and Sensing Techniques
- Endoplasmic Reticulum Stress and Disease
- Proteins in Food Systems
- Enzyme Structure and Function
- Cellular Mechanics and Interactions
- Infant Nutrition and Health
- Advanced Chemical Sensor Technologies
- Fatty Acid Research and Health
- 3D Printing in Biomedical Research
- Neuroscience and Neuropharmacology Research
- Biotin and Related Studies
- Mass Spectrometry Techniques and Applications
- Consumer Attitudes and Food Labeling
Agroscope
2014-2024
Federal Office for Agriculture
2012-2022
Federal Department of Economic Affairs, Education and Research
2012-2022
Wageningen University & Research
2022
University of Bern
2022
SIB Swiss Institute of Bioinformatics
2022
Association Fribourgeoise des Psychologues
2005
University of Fribourg
2004
University of Basel
1995-2000
University of Calgary
2000
Within the active field of in vitro digestion food research, COST Action INFOGEST aimed to harmonize protocols simulating human on basis physiologically inferred conditions. A harmonized static (IVD) method was recently published as a primary output from this network. To validate protocol, inter-laboratory trials were conducted within first study performed using skim milk powder (SMP) model and served compare different in-house used among members. In second applying degree consistency...
The proteins of the MARCKS (myristoylated alanine-rich C kinase substrate) family were first identified as prominent substrates protein (PKC). Since then, these have been implicated in regulation brain development and postnatal survival, cellular migration adhesion, well endo-, exo- phago-cytosis, neurosecretion. effector domain is phosphorylated by PKC, binds to calmodulin contributes membrane binding. This multitude mutually exclusive interactions allows cross-talk between signal...
In the frame of COST action INFOGEST, a static in vitro digestion protocol has been elaborated aiming at improvement data comparability by harmonizing experimental conditions. The success harmonization was confirmed with inter-laboratory trials using skim milk powder as standardized model food. Moreover, physiological relevance gastric and intestinal endpoints demonstrated pig vivo trial, same samples collected from different sections digestive tract, well human study jejunal effluents....
Recently, a static in vitro digestion (IVD) protocol was published by Minekus and coworkers (Minekus et al., 2014) within the COST INFOGEST network. The protocol, concentrating on physiological enzyme activities had main goal to improve comparability of experimental data between labs. validated several inter-laboratory studies using skim milk powder (SMP) indeed demonstrated improved harmonization compared with previous experiments individual IVD protocols (Egger 2016). Although salt...
This focus article introduces the concept of NutriChip, an integrated microfluidic platform for investigating potential immuno-modulatory function dairy food. The core component NutriChip is a miniaturized artificial human gastrointestinal tract (GIT), which consists confluent layer epithelial cells separated from co-culture immune by permeable membrane. setting creates conditions mimicking GIT and allows studying processes that characterize passage nutrients though GIT, including activation...
Probiotic yogurt and milk supplemented with probiotics have been investigated for their role in 'low-grade' inflammation but evidence efficacy is inconclusive. This study explores the impact of probiotic on metabolic inflammatory biomarkers, a parallel gut microbiota dynamics. The randomised cross-over was conducted fourteen healthy, young men to test compared acidified 2 % d-(+)-glucono-δ-lactone during 2-week intervention (400 g/d). Fasting assessments, high-fat meal (HFM) analyses were...
The measurement of food intake biomarkers (FIBs) in biofluids represents an objective tool for dietary assessment. FIBs milk and cheese still need more investigation due to the absence candidate markers. Thus, acute intervention study has been performed sensitively specifically identify FIBs. Eleven healthy male female volunteers participated randomized, controlled crossover that tested a single as test products, soy-based drink control. Urine samples were collected at baseline up 24 h...
Endothelial cells express negligible amounts of tissue factor (TF) that can be induced by thrombin, which is important for acute coronary syndromes. Recent research suggests endothelial TF expression positively regulated RhoA and p38mapk, but negatively Akt/endothelial nitric oxide synthase (eNOS) pathway. High-density lipoprotein (HDL) atheroprotective exerts antiatherothrombotic effect. This study investigated the effect a reconstituted HDL (rHDL) on thrombin underlying mechanisms. In...
Fermentation is a widely used method of natural food preservation that has consequences on the nutritional value transformed food. Fermented dairy products are increasingly investigated in view their ability to exert health benefits beyond qualities. To explore mechanisms underpinning fermented intake, present study followed effects milk fermentation, from changes product metabolome human serum after its ingestion. A randomized crossover design was conducted 14 healthy men [mean age: 24.6 y;...
The identification and validation of food intake biomarkers (FIBs) in human biofluids is a key objective for the evaluation dietary intake. We report here analysis GC-MS 1H-NMR metabolomes serum samples from randomized cross-over study 11 healthy volunteers having consumed isocaloric amounts milk, cheese, soy drink as non-dairy alternative. Serum was collected at baseline, postprandially up to 6 h, 24 h after consumption. A multivariate untargeted metabolomes, combined with targeted...