A5031121527- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Sexual Differentiation and Disorders
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Historical and Literary Studies
- Diabetes Management and Research
- Testicular diseases and treatments
- Pituitary Gland Disorders and Treatments
- Historical and Literary Analyses
- Genetics and Neurodevelopmental Disorders
- Folate and B Vitamins Research
- Infant Nutrition and Health
- Hypothalamic control of reproductive hormones
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Congenital Ear and Nasal Anomalies
- Digestive system and related health
- Cultural Insights and Digital Impacts
- Meningioma and schwannoma management
- Genomics and Rare Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Gestational Diabetes Research and Management
- Intestinal Malrotation and Obstruction Disorders
CHU Dinant Godinne UCL Namur
2016-2024
Rutgers, The State University of New Jersey
2024
Hospital General de Niños Ricardo Gutierrez
2024
Monash University
2024
Royal Manchester Children's Hospital
2024
University Hospital in Motol
2024
Bambino Gesù Children's Hospital
2024
IRCCS Materno Infantile Burlo Garofolo
2024
UCLouvain
2006-2023
KU Leuven
1998-2021
The onset of puberty is first detected as an increase in pulsatile secretion gonadotropin-releasing hormone (GnRH). Early activation the hypothalamic–pituitary–gonadal axis results central precocious puberty. timing pubertal development driven part by genetic factors, but only a few, rare molecular defects associated with have been identified.
Growth hormone (GH) is prescribed for an increasing range of indications, but there has been concern that it might raise cancer risk. Published data are limited. To examine risks in relation to GH treatment. Cohort study. Population-based. 23,984 patients treated with recombinant human (r-hGH) eight European countries since this treatment was first used 1984. Cancer expectations from country-specific national population statistics. incidence and mortality. Incidence mortality the cohort were...
Tpit is a T box transcription factor important for terminal differentiation of pituitary proopiomelanocortin-expressing cells. We demonstrated that human and mouse mutations the TPIT gene cause neonatal-onset form congenital isolated ACTH deficiency (IAD). In absence glucocorticoid replacement, IAD can lead to neonatal death by acute adrenal insufficiency. This clinical entity was not previously well characterized because small number published cases. Since identification first mutations, we...
Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder with different nutritional phases from suckling deficit failure to thrive early onset of obesity. Hyperghrelinemia has been described in PWS long before the development Ghrelin found both acylated (AG) and unacylated (UAG) forms circulation. In contrast AG, UAG shown inhibit food intake be elevated anorexia nervosa. The present project aiming determine underlying mechanisms driving PWS.Measurement at least 4 h-fasting...
Objective: Achieving good metabolic control in people with type 1 diabetes (T1D) remains a challenge, despite the evolutions technologies over past decade. Here we investigate evolution of T1D, where care is provided by specialized centers access to technology, education, and regular follow-up. Methods: Data were cross-sectionally collected between 2010 2018 from more than 100 Belgium. The time hemoglobin A1C (HbA1c), low-density lipoprotein (LDL) cholesterol, systolic blood pressure (SBP)...
Abstract Context Primary Ovarian insufficiency (POI) affects 1% of women aged <40 years and leads most often to definitive infertility with adverse health outcomes. Very recently, genes involved in deoxyribonucleic acid (DNA) repair have been shown cause POI. Objective To identify the a familial POI consanguineous Turkish family. Design Exome sequencing was performed proposita her mother. Chromosomal breaks were studied lymphoblastoid cell lines treated mitomycin (MMC). Setting...
<b><i>Background:</i></b> KBG syndrome is a rare disorder characterized by intellectual disability and associated with macrodontia of the upper central incisors, specific craniofacial findings, short stature skeletal anomalies. Genetic corroboration clinical diagnosis has been possible since 2011, upon identification heterozygous mutations in or deletion <i>ANKRD11</i> gene. <b><i>Methods:</i></b> We summarized height data 14 adults...
Abstract Context There has been concern that GH treatment of children might increase meningioma risk. Results published studies have inconsistent and limited. Objective To examine risks in relation to treatment. Design Cohort study with follow-up via cancer registries other registers. Setting Population-based. Patients A cohort 10,403 patients treated childhood recombinant five European countries since this was first used 1984. Expected rates from national registration statistics. Main...
Rhabdomyolysis is a potentially lethal disorder, characterized by elevated serum concentrations of creatine kinase (CK) due to skeletal muscle injury. In this paper patient with diabetic ketoacidosis (DKA) reported who developed rhabdomyolysis (maximum CK level, 37,700 U/L; normal, < 170 U/L), anemia (6.2 g/dL) and thrombocytopenia (16,000/microL). This combination has not yet been in DKA. The pathogenic mechanism leading DKA remains unsettled. From the literature it seems that those...
Children with Prader-Willi Syndrome (PWS) have been considered at risk for central adrenal insufficiency (CAI). Hypothalamic dysregulation has proposed as a common mechanism underlying both stress-induced CAI and respiratory dysfunction during sleep.To evaluate sleep-related breathing disorders in PWS children.Retrospective study of cortisol response following either insulin tolerance test (ITT) or glucagon (GT) 20 children, comparison 33 non- Growth Hormone deficient (GHD) controls....
Objectives The treatment of brain tumors in childhood is frequently complicated by growth retardation with a high proportion irradiation (Irr)-induced GH deficiency (GHD) resulting reduced adult final height (AFH) even after therapy (GHT). In order to optimize future GHT protocols, more information on the factors influencing response these children needed. This retrospective study evaluated AFH and auxological standardized daily biosynthetic survivors documented GHD Irr. Design methods From...
Boltzmann relations are widely used in semiconductor physics to express the charge-carrier densities as a function of Fermi level and temperature. However, these simple exponential only apply sharp band edges conduction valence bands. In this article, we present generalization accounting for tails. To end, required Fermi-Dirac integral is first recast Gauss hypergeometric function, followed by suitable transformation that special zeroth-order series expansion using series. This results...
A substantial proportion of SGA patients present with a syndrome underlying their growth restriction. Most cohorts comprise both syndromic and non-syndromic impeding delineation the recombinant human hormone (rhGH) response. We detailed characterization cohort analyze rhGH response based on adult height (AH).Clinical auxological data treated rhGH, who had reached AH, were retrieved from BELGROW, national database all held by BESPEED (BElgian Society for PEdiatric Endocrinology Diabetology)....
Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer deficient when retested after cessation therapy final height is achieved. These labelled as transient GHD. We hypothesized normalization secretion in GHD could occur earlier the course treatment, which allow treatment.In a retrospective study, was re-evaluated treatment at 43 diagnosed (10 multiple pituitary hormonal deficiencies (MPHD) and 33...
Objectives . Information on the efficacy of GH treatment in short SGA children starting their adolescence is limited. Therefore, adult height (AH), total gain, and pubertal gain were evaluated who started at onset. Patient Methods Growth data 47 adolescents (22 boys) onset (PUB group) compared with results from 27 patients (11 therapy least 1 year before (PrePUB group). Results The PUB group achieved a mean (±SD) 0.8 ± 0.7 SDS an AH −2.5 after 4.1 1.1 years dosage 41.8 8.4 μ g/kg/day. These...
Objective and design : Children born small for gestational age (SGA) are not only at risk short stature, but also neurodevelopmental behavioral problems. In this study, we analyzed the effects of high-dose GH therapy on cognitive development psychosocial functioning in 34 prepubertal (3–8 years) SGA children, equally randomized into a GH-treated group (TRG) an untreated (UTRG). Methods At start after 2 years, children underwent standardized tests measuring intellectual abilities (Wechsler...
Abstract Purpose In a significant proportion of children born small for gestational age (SGA) with failure catch-up growth, the etiology short stature remains unclear after routine diagnostic workup. We wanted to investigate if extensive analysis (epi)genome can unravel cause growth in portion these children. Patients and Methods Twenty SGA treated GH because were selected from BELGROW database Belgian Society Pediatric Endocrinology Diabetology exome sequencing, single-nucleotide...
<i>Background/Aims:</i> Few data are available about parental concerns and psychosocial functioning of young children born small for gestational age (SGA) treated with growth hormone (GH). The present study focused on the perception short stature expectations parents regarding GH treatment. <i>Methods:</i> Forty prepubertal SGA children, randomized into a GH-treated GH-untreated group, their were evaluated by questionnaire semi-structured interview at start after 2...