A5072663603- Reproductive Biology and Fertility
- Hepatitis C virus research
- Thyroid Disorders and Treatments
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Shoulder Injury and Treatment
- Vector-Borne Animal Diseases
- Gout, Hyperuricemia, Uric Acid
- Viral Infectious Diseases and Gene Expression in Insects
- Thyroid Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Rabies epidemiology and control
- Ovarian function and disorders
- Hip disorders and treatments
- Shoulder and Clavicle Injuries
- Hypertrophic osteoarthropathy and related conditions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- T-cell and B-cell Immunology
- Spondyloarthritis Studies and Treatments
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Renal and related cancers
- Migraine and Headache Studies
Assistance Publique – Hôpitaux de Paris
2020-2023
Pitié-Salpêtrière Hospital
2023
Sorbonne Université
2022-2023
Université Paris-Saclay
2014-2022
Bicêtre Hospital
2015-2022
Université Paris-Sud
2014-2022
Centre d'Immunologie et des Maladies Infectieuses
2022
Inserm
2022
Hôpitaux Universitaires Paris-Ouest
2020
Centre National de la Recherche Scientifique
2012-2014
The Hsp70 chaperone plays a central role in multiple processes within cells, including protein translation, folding, intracellular trafficking, and degradation. This is implicated the replication of numerous viruses. We have shown that rabies virus infection induced cellular expression Hsp70, which accumulated Negri body-like structures, where viral transcription take place. In addition, present both nucleocapsids purified from infected cells virions. has been to interact with nucleoprotein...
Primary Ovarian Insufficiency (POI) affects ~1% of women under forty. Exome sequencing two Finnish sisters with non-syndromic POI revealed a homozygous mutation in FANCM, leading to truncated protein (p.Gln1701*). FANCM is DNA-damage response gene whose heterozygous mutations predispose breast cancer. Compared the mother's cells, patients' lymphocytes displayed higher levels basal and mitomycin C (MMC)-induced chromosomal abnormalities. Their lymphoblasts were hypersensitive MMC MMC-induced...
ABSTRACT The rabies virus (RABV) phosphoprotein P is a multifunctional protein: it plays an essential role in viral transcription and replication, addition, RABV has been identified as interferon antagonist. Here, yeast two-hybrid screen revealed that interacts with the focal adhesion kinase (FAK). binding involved 106-to-131 domain, corresponding to dimerization domain of C-terminal FAK containing proline-rich domains PRR2 PRR3. P-FAK interaction was confirmed infected cells by...
Abstract Context Primary Ovarian insufficiency (POI) affects 1% of women aged <40 years and leads most often to definitive infertility with adverse health outcomes. Very recently, genes involved in deoxyribonucleic acid (DNA) repair have been shown cause POI. Objective To identify the a familial POI consanguineous Turkish family. Design Exome sequencing was performed proposita her mother. Chromosomal breaks were studied lymphoblastoid cell lines treated mitomycin (MMC). Setting...
The role of immune checkpoints (ICPs) in both anti-HIV T cell exhaustion and HIV reservoir persistence, has suggested that an cure therapeutic strategy could involve ICP blockade. We studied the impact anti-PD-1 therapy on reservoirs anti-viral responses people living with treated for cancer. At several timepoints, we monitored CD4 counts, plasma HIV-RNA, associated (CA) HIV-DNA, EBV, CMV, HBV, HCV, HHV-8 viral loads, activation markers, expression virus-specific cells. Thirty-two patients...
Premature ovarian insufficiency (POI) affects 1% to 2% of women under 40 years. Bone morphogenetic protein 15 (BMP15) variants have been described in POI. We studied a family with 2 sisters compound heterozygous for deletions the BMP15 gene on chromosome Xp11.22 yielding human "knockout-like" effect: c.151_152delGA deletion yielded p.Glu51IlefsTer27 mutation transmitted by hemizygous father and c.189_198delAGGGCATTCAinsTG deletion/insertion p.Glu64AlafsTer12 mother. Both resulted frameshifts...
Endometriosis, the hormone-dependent extrauterine dissemination of endometrial tissue outside uterus, affects 5-15% women reproductive age. Pathogenesis remains poorly understood as well estrogen production by endometriotic yielding autocrine growth. Estrogens (E2) are normally produced ovaries. We investigated whether aberrant "ovarian-like" differentiation occurred in endometriosis. 69 women, with (n = 38) and without 31) histologically proven endometriosis were recruited. Comparative...
The clinical course of Hepatitis C Virus (HCV) infection is highly variable between infected individual hosts: up to 80% acutely HCV patients develop a chronic while 20% clear spontaneously. Spontaneous clearance can be predicted by several factors, including symptomatic acute infection, favorable IFNL3 polymorphisms and gender. In our study, we explored the possibility that variants in cell entry factors might involved resistance infection. same case patient exposed but not HCV, previously...
Hepatitis C virus (HCV) causes persistent infection in 75% of cases and is a major public health problem worldwide. More than 92% intravenous drug users (IDU) infected by human immunodeficiency type 1 (HIV-1) are seropositive for HCV, it conceivable that some HIV-1-infected IDU who remain uninfected HCV may be genetically resistant.Here we conducted case-control study to identify mutations entry coreceptors HIV-infected remained HCV. We recruited 138 patients, comprising 22 HIV+ HCV- case...
Hepatitis C virus (HCV) seroprevalence is highly diverse among human immunodeficiency virus‐1 (HIV‐1) infected patients, ranging between 10% of HIV‐1 homo‐bisexuel men, to >92% in patients with who acquired through intravenous drug use. Thus, being HCV‐free while having via use a rare situation. Claudin‐1 protein involved intracellular tight‐junctions and has been identified as major cellular co‐receptor for HCV infection. Our objective was determine whether gene ( CLDN1 ) mutations might...