A5024327778- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Gut microbiota and health
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Probiotics and Fermented Foods
- Digestive system and related health
- Advanced Chemical Sensor Technologies
- Genomics and Phylogenetic Studies
- Nutrition and Health in Aging
- Phytoestrogen effects and research
- Diet, Metabolism, and Disease
- Stoma care and complications
- Odor and Emission Control Technologies
- Bioinformatics and Genomic Networks
- Muscle metabolism and nutrition
- Meat and Animal Product Quality
- Biochemical Analysis and Sensing Techniques
Agroscope
2017-2024
University of Bern
2022
SIB Swiss Institute of Bioinformatics
2022
Federal Department of Economic Affairs, Education and Research
2017-2020
University of Lausanne
2017-2018
Federal Office for Agriculture
2017-2018
University Hospital of Lausanne
2017
AgroParisTech
2013-2016
Université Paris-Saclay
2016
Universidade Estadual de Campinas (UNICAMP)
2012
Probiotic yogurt and milk supplemented with probiotics have been investigated for their role in 'low-grade' inflammation but evidence efficacy is inconclusive. This study explores the impact of probiotic on metabolic inflammatory biomarkers, a parallel gut microbiota dynamics. The randomised cross-over was conducted fourteen healthy, young men to test compared acidified 2 % d-(+)-glucono-δ-lactone during 2-week intervention (400 g/d). Fasting assessments, high-fat meal (HFM) analyses were...
The measurement of food intake biomarkers (FIBs) in biofluids represents an objective tool for dietary assessment. FIBs milk and cheese still need more investigation due to the absence candidate markers. Thus, acute intervention study has been performed sensitively specifically identify FIBs. Eleven healthy male female volunteers participated randomized, controlled crossover that tested a single as test products, soy-based drink control. Urine samples were collected at baseline up 24 h...
Fermentation is a widely used method of natural food preservation that has consequences on the nutritional value transformed food. Fermented dairy products are increasingly investigated in view their ability to exert health benefits beyond qualities. To explore mechanisms underpinning fermented intake, present study followed effects milk fermentation, from changes product metabolome human serum after its ingestion. A randomized crossover design was conducted 14 healthy men [mean age: 24.6 y;...
The identification and validation of food intake biomarkers (FIBs) in human biofluids is a key objective for the evaluation dietary intake. We report here analysis GC-MS 1H-NMR metabolomes serum samples from randomized cross-over study 11 healthy volunteers having consumed isocaloric amounts milk, cheese, soy drink as non-dairy alternative. Serum was collected at baseline, postprandially up to 6 h, 24 h after consumption. A multivariate untargeted metabolomes, combined with targeted...
The metabolic health benefits of fermented milks have already been investigated using clinical biomarkers but the development transcriptomic analytics in blood offers an alternative approach that may help to sensitively characterise such effects. We aimed assess effects probiotic yoghurt intake, compared non-fermented, acidified milk on and gene expression peripheral blood. To this end, a randomised, crossover study was conducted fourteen healthy, young men test two dairy products. For...
Abstract The absence of a dedicated transport for disaccharides in the intestine implicates that metabolic use dietary lactose relies on its prior hydrolysis at intestinal brush border. Consequently, blood or urine has mostly been associated with specific cases which gastrointestinal barrier is damaged. On other hand, appears lactating women and detected healthy men, indicating presence circulation subjects not incompatible normal physiology. In this cross-over study we have characterised...
The use of biomarkers food intake (BFIs) in blood and urine has shown great promise for assessing dietary complementing traditional assessment tools whose is prone to misreporting. Untargeted LC-MS metabolomics was applied identify candidate BFIs the milk cheese explore metabolic response ingestion these foods. A randomized controlled crossover study conducted healthy adults [5 women, 6 men; age: 23.6 ± 5.0 y; BMI (kg/m2): 22.1 1.7]. After a single isocaloric (600 mL), (100 g), or soy-based...
We tested the hypothesis that, for rats fed a high-fat diet (HFD), prioritization of maintaining protein intake may increase energy consumption and hence result in obesity, particularly individuals prone to obesity ("fat sensitive," FS, vs. "fat resistant," FR). Male Wistar (n = 80) first received 3 wk HFD (protein 15%, fat 42%, carbohydrate 42%), under which they were characterized as being FS 18) or FR 20) based on body weight gain. They then continued same but (100%) was available...
The novel concept of 'Nutritional Biomarkers Health' (NBH) is introduced in this paper. In analogy to glucose, metabolites blood that (i) respond postprandially the ingestion foods, (ii) differentiate healthy individuals from with metabolic diseases under fasting and/or postprandial conditions, and (iii) have plausible mechanisms associate them diseases, may qualify as NBHs. use metabolomics link food composition status a subject after offers unique approach for identification NBHs thus,...
Abstract Unraveling bacterial gene function drives progress in various areas, such as food production, pharmacology, and ecology. While omics technologies capture high-dimensional phenotypic data, linking them to genomic data is challenging, leaving 40–60% of genes undescribed. To address this bottleneck, we introduce Scoary2 , an ultra-fast microbial genome-wide association studies (mGWAS) software. With its exploration app improved performance, the first tool enable study large datasets...
To investigate dietary influences on the volatilome, volatile subcategory of metabolome, we performed a comparative untargeted volatilome analysis exhaled breath, ruminal fluid, serum, urine, and milk from lactating Holstein cows fed different diets. Thirty-two (79.4 ± 31.3 d in [DIM], 30.6 4.83 kg milk/d) were assigned to 4 The experiment lasted 16 weeks. Throughout experiment, half animals hay-based diet (HAY; n = 16), other silage-based (SIL; 16). In experimental wk 5 12, each group...
Combining different "omics" data types in a single, integrated analysis may better characterize the effects of diet on human health.The performance two integration tools, similarity network fusion tool (SNFtool) and Data Integration Analysis for Biomarker discovery using Latent variable approaches "Omics" (DIABLO; MixOmics), discriminating responses to metabolic phenotypes is investigated by combining transcriptomics metabolomics datasets from three intervention studies: postprandial...
Identification of food intake biomarkers (FIBs) for fermented foods could help improve their dietary assessment and clarify associations with cardiometabolic health. We aimed to identify novel FIBs in the plasma urine metabolomes 246 free-living Dutch adults using nontargeted LC-MS GC-MS. Furthermore, between identified metabolites several risk factors were explored. In total, 37 corresponding intakes coffee, wine, beer (none cocoa, bread, cheese, or yoghurt intake). While some these...
The identification of molecular biomarkers that can be used to quantitatively link dietary intake phenotypic traits in humans is a key theme modern nutritional research. Although dairy products (with and without fermentation) represent major food group, the markers their lags behind other groups. Here, we report results from an analysis metabolites postprandial serum urine samples randomized crossover study with 14 healthy men who ingested acidified milk, yogurt, non-dairy meal. Our confirms...
Aging and physical inactivity are 2 factors that favour the development of cardiovascular disease, metabolic syndrome, obesity, diabetes. In contrast, adopting a habitual moderate exercise routine may be nonpharmacological treatment alternative for neuroendocrine aging disorders. We aimed to assess effects training on profiles elderly people with sedentary lifestyles. Fourteen sedentary, healthy, male volunteers participated in regimen 60 min/day, 3 days/week 24 weeks at work rate equivalent...
Abstract Genomic screening of bacteria is common practice to select strains with desired properties. However, 40-60% all bacterial genes are still unknown, making capturing the phenotype an important part selection process. While omics-technologies collect high-dimensional phenotypic data, it remains challenging link this information genomic data elucidate impact specific on phenotype. To end, we present Scoary2, ultra-fast software for microbial genome-wide association studies (mGWAS),...
Dietary fat is among the factors often considered responsible for high prevalence of adiposity. Both genetic and epigenetic influence who in a population will develop adiposity it established that humans as well rodent models are not uniformly sensitive to gain under diets. In addition also recognized when placed on dietary self‐selection (DSS) conditions, most species generally able select an adequate diet growth maintenance. cases, caloric intake body weight suggest DSS closely related...
Biomarkers of food intake are currently intensively investigated in the frame European Project `Food Biomarker Alliance` (FoodBAll) for a wide range foods. In future, validated biomarkers will serve as tool dietary assessment enabling objective link between diet and disease outcomes epidemiological studies. The randomized, controlled crossover study presented here aimed to identify urinary serum two products public health relevance, milk cheese, addition soy-based control. Eleven healthy...
The dynamic, postprandial response of the human organism to acute ingestion food is a key element nutritional sciences as it directly associates with its impact on metabolism. study this can thus facilitate sensitive characterization metabolic foods that are similar but which differ in compositional or structural features. relevance analysis strategy be potentiated by (i) complementing classical biochemical analyses ‘omic` methods, such metabolomics and transcriptomics, using blood...