A5101974866- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Advanced Chemical Sensor Technologies
- Diet, Metabolism, and Disease
- Digestive system and related health
- Biochemical Analysis and Sensing Techniques
- Fatty Acid Research and Health
- Gut microbiota and health
- Consumer Attitudes and Food Labeling
- Analytical Chemistry and Chromatography
- Meat and Animal Product Quality
- Probiotics and Fermented Foods
- IL-33, ST2, and ILC Pathways
- Bioinformatics and Genomic Networks
- Natural Products and Biological Research
- Liver Disease Diagnosis and Treatment
- Protein Hydrolysis and Bioactive Peptides
- Infant Nutrition and Health
Agroscope
2018-2024
Federal Department of Economic Affairs, Education and Research
2018-2023
Wageningen University & Research
2022
Federal Office for Agriculture
2021-2022
University of Lausanne
2018-2022
Abstract On-line breath analysis using secondary electrospray ionization coupled to high-resolution mass spectrometry (SESI-HRMS) is a sensitive method for biomarker discovery. The strengths of this technology have already been demonstrated in the clinical environment. For first time, study demonstrates application SESI-HRMS field nutritional science standardized intervention, consisting high-energy shake (950 kcal, 8% protein, 35% sugar and 57% fat). Eleven subjects underwent intervention...
Abstract Background Whereas the dietary intake of industrial trans fatty acids (iTFA) has been specifically associated with inflammation, cardiovascular disease, and type 2 diabetes, understanding impact fats on human health remains challenging owing to their complex composition individual effects lipid components metabolism. The aim this study is profile blood, measured by acid (FAs) untargeted metabolome serum transcriptome blood cells, in order identify molecular signatures that...
Lactase is an enzyme that hydrolyzes lactose into glucose and galactose in the small intestine, where they are absorbed. Hypolactasia a common condition, primarily caused by genetic programming, leads to maldigestion and, certain cases, intolerance. Galactitol galactonate 2 products of hepatic metabolism candidate markers for intake lactose-containing foods.The primary objective study was explore changes serum urine metabolomes during postprandial dairy product tests through association...
The characterization of volatile compounds in biological fluids offers a distinct approach to study the metabolic imprint foods on human metabolome, particularly identify novel biomarkers food intake (BFIs) that are not captured by classic metabolomics. Using combination dynamic headspace vacuum transfer In Trap extraction and gas chromatography coupled with mass spectrometry, we measured (the "volatilome") plasma urine samples from randomized controlled crossover intervention which 11...
Identification of food intake biomarkers (FIBs) for fermented foods could help improve their dietary assessment and clarify associations with cardiometabolic health. We aimed to identify novel FIBs in the plasma urine metabolomes 246 free-living Dutch adults using nontargeted LC-MS GC-MS. Furthermore, between identified metabolites several risk factors were explored. In total, 37 corresponding intakes coffee, wine, beer (none cocoa, bread, cheese, or yoghurt intake). While some these...
Combining different "omics" data types in a single, integrated analysis may better characterize the effects of diet on human health.The performance two integration tools, similarity network fusion tool (SNFtool) and Data Integration Analysis for Biomarker discovery using Latent variable approaches "Omics" (DIABLO; MixOmics), discriminating responses to metabolic phenotypes is investigated by combining transcriptomics metabolomics datasets from three intervention studies: postprandial...
Milk-derived free fatty acids (FFAs) may act as both biomarkers of intake and metabolic effect. In this study we explored associations between different types dairy consumption, a selection milk-derived acids, cardiometabolic disease (CMD) risk factors.Sixty-seven FFAs were quantified in the plasma 131 free-living Dutch adults (median 60 years) using gas chromatography-flame ionization detector. Intakes foods groups assessed food frequency questionnaire. Twelve CMD factors analyzed. Multiple...
Studies examining associations between self-reported dairy intake and health are inconclusive, but biomarkers hold promise for elucidating such relationships by offering objective measures of dietary intake. Previous human intervention studies identified several foods in blood urine using non-targeted metabolomics. We evaluated the robustness these a free-living cohort Netherlands both single- multi-marker approaches. Plasma from 246 participants (54 ± 13 years) who completed food frequency...
The gut microbiota adapts to age-related changes in host physiology but is also affected by environmental stimuli, like diet. As a source of both pre- and probiotics, dairy fermented foods modulate the composition, which makes them interesting food groups use for investigation interactions between diet ageing. Here we present effects excluding products limiting consumption 19 days on composition circulating metabolites 28 healthy, young (YA) older (OA) adult men. intervention microbial...
The identification of molecular biomarkers that can be used to quantitatively link dietary intake phenotypic traits in humans is a key theme modern nutritional research. Although dairy products (with and without fermentation) represent major food group, the markers their lags behind other groups. Here, we report results from an analysis metabolites postprandial serum urine samples randomized crossover study with 14 healthy men who ingested acidified milk, yogurt, non-dairy meal. Our confirms...
Two randomized placebo-controlled double-blind paralleled trials (42 men in Lyon, 19 women Lausanne) were designed to test 2 g/day of a grape polyphenol extract during 31 days high calorie-high fructose overfeeding. Hyperinsulinemic-euglycemic clamps and meals with [1,1,1-13C3]-triolein performed before at the end intervention. Changes body composition assessed by dual-energy X-ray absorptiometry (DEXA). Fat volumes abdominal region liver fat content determined only, using 3D-magnetic...
ABSTRACT Indole derivatives are microbial metabolites of the tryptophan pathway involved in gut immune homeostasis. They bind to aryl hydrocarbon receptor (AhR), thereby modulating development intestinal group 3 innate lymphoid cells (ILC3) and subsequent interleukin-22 production. In mice, indole maternal microbiota can reach milk drive early postnatal ILC3 development. Apart from microbiota, lactic acid bacteria (LAB) also produce compounds during fermentation. Using germ-free aim our...
<sec> <title>BACKGROUND</title> Fermented foods vary significantly by food substrate and regional consumption patterns. While consumed worldwide, their potential health benefits remain understudied. Europe, in particular, lacks specific recommendations for most fermented foods. </sec> <title>OBJECTIVE</title> This project, which is under the framework of PIMENTO COST Action (CA20128), aims to develop a validated tool quantitatively estimate intake across European Regions....
Abstract Background: Dietary intake of industrial trans fatty acids (iTFA) is associated with inflammation, cardiovascular disease and type 2 diabetes but it unclear whether naturally occurring (TFA) exert these effects. Methods: In a parallel study, the molecular effects consuming dairy fat containing ruminant TFA (rTFA) or margarine iTFA were investigated. After run-in period without (wTFA), 42 healthy volunteers (45 to 69 y), randomly assigned diets enriched wTFA (control), iTFA, alpine...
All living creatures need to eat. Eating a variety of different healthy foods in moderate amounts is important. How do we know which are healthy? Researchers can compare the consumed by and unhealthy people asking what how much they Unfortunately, cannot always remember eat, makes it difficult figure out healthy. Recently, researchers discovered that group research tools called omics could help. When building blocks food broken down into small compounds metabolites. With laboratory...
Nutritional biomarkers of dairy intake can be affected by both food transformation and the metabolic status consumer. To assess these effects, this study investigated serum volatilome 14 young (YA) older (OA) adult men undergoing a 3 week restriction fermented foods followed randomized crossover acute milk yogurt. 3,5-Dimethyl-octan-2-one was identified as potential marker product its response after yogurt significantly increased during postprandial phase but decreased in fasting samples OA...