A5052574241- Advanced MRI Techniques and Applications
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- Spectroscopy and Chemometric Analyses
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Ultrasound Imaging and Elastography
- Lanthanide and Transition Metal Complexes
- Fault Detection and Control Systems
- Elasticity and Material Modeling
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Disease and Adiposity
- Ultrasound and Hyperthermia Applications
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Sparse and Compressive Sensing Techniques
- Functional Brain Connectivity Studies
- Advanced Chemical Sensor Technologies
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2014-2025
Université Claude Bernard Lyon 1
2015-2025
Centre National de la Recherche Scientifique
2015-2025
Inserm
2015-2025
Chimie et Biologie des Membranes et des Nanoobjects
2015-2024
Institut National des Sciences Appliquées de Lyon
2008-2023
Université Jean Monnet
2018-2019
University of California, San Francisco
2007-2014
Laboratoire Traitement du Signal et de l'Image
2002-2010
Health First
2010
A novel and fast time-domain quantitation algorithm—quantitation based on semi-parametric quantum estimation (QUEST)—invoking optimal prior knowledge is proposed tested. This nonlinear least-squares algorithm fits a model function, made up from basis set of quantum-mechanically simulated whole-metabolite signals, to low-SNR in vivo data. vitro measured signals can be used too. The was created with the software package NMR-SCOPE which invoke various experimental protocols. Quantitation 1H...
Predicting disease evolution is becoming essential for optimizing treatment decision making in multiple sclerosis (MS). Multiple pathologic damage typically includes demyelination, neuro-axonal loss, and astrogliosis.To evaluate the potential of magnetic resonance markers central nervous system injury to predict brain-volume loss clinical disability sclerosis.Participants were selected from Sclerosis Center at University California-San Francisco. The preliminary data set included 59 patients...
Abstract Purpose To measure T 1 and 2 relaxation times of metabolites in glioma patients at 3T to investigate how these values influence the observed metabolite levels. Materials Methods A total 23 with gliomas 10 volunteers were studied single‐voxel two‐dimensional (2D) J‐resolved point‐resolved spectral selection (PRESS) using a MR scanner. Voxels chosen normal appearing white matter (WM) regions tumor. The choline containing compounds (Cho), creatine (Cr), N‐acetyl aspartate (NAA)...
Preterm birth represents a high risk of neurodevelopmental disabilities when associated with white-matter damage. Recent studies have reported cognitive deficits in children born preterm without brain injury on MRI at term-equivalent age. Understanding the microstructural and metabolic underpinnings these is essential for their early detection. Here, we used diffusion-weighted imaging single-voxel 1H magnetic resonance spectroscopy (MRS) to compare maturation age premature neonates no...
Background Overweight and obesity are major worldwide health concerns characterized by an abnormal accumulation of fat in adipose tissue (AT) liver. Purpose To evaluate the volume fatty acid (FA) composition subcutaneous (SAT) visceral (VAT) content liver from 3D chemical‐shift‐encoded (CSE)‐MRI acquisition, before after a 31‐day overfeeding protocol. Study Type Prospective longitudinal study. Subjects Twenty‐one nonobese healthy male volunteers. Field Strength/Sequence A spoiled‐gradient...
Background Diffusion‐weighted imaging (DWI) has been considered for chronic liver disease (CLD) characterization. Grading of fibrosis is important management. Purpose To investigate the relationship between DWI's parameters and CLD‐related features (particularly regarding assessment). Study Type Retrospective. Subjects Eighty‐five patients with CLD (age: 47.9 ± 15.5, 42.4% females). Field Strength/Sequence 3‐T, spin echo‐echo planar (SE‐EPI) 12 b ‐values (0–800 s/mm 2 ). Assessment Several...
Abstract High Resolution – Magic Angle Spinning (HR‐MAS) spectroscopy provides rich biochemical profiles that require accurate quantification to permit biomarker identification and understand the underlying pathological mechanisms. Meanwhile, of HR‐MAS data from prostate tissue samples is challenging due significant overlap between resonant peaks, presence short $T_{2}^{*} $ metabolites such as citrate or polyamines (T 2 25 100 msec) macromolecules, variations in chemical shifts s within a...
The assessment of liver lipid content and composition is needed in preclinical research to investigate steatosis steatosis-related disorders. purpose this study was quantify vivo hepatic fatty acid using a method based on short echo time proton magnetic resonance spectroscopy (MRS) at 7 Tesla. A mouse model glycogen storage disease type 1a with inducible liver-specific deletion the glucose-6-phosphatase gene (L-G6pc−/−) mice control were fed standard diet or high-fat/high-sucrose (HF/HS) for...
Introduction The composition of fatty acids in the body is gaining increasing interest, and can be followed up noninvasively by quantitative magnetic resonance spectroscopy (MRS). However, current MRS quantification methods have been shown to provide different results terms lipid signals, with possible varying outcomes for a given biological examination. Quantitative imaging using multigradient echo sequence (MGE‐MRI) has recently added approaches. In contrast, these fit undersampled...
Objectives: The aim of this study was to investigate the feasibility measuring effects 14-days low-calory-diet (<200cal) on multi-organs main interest (liver, visceral/subcutaneous/bone marrow fat, muscle) using non-invasive advanced spectroscopic moreover magnetic resonance imaging (MRI) methods. Methods: One subject participated in a 14-day fast under daily supervision nurses and specialized physicians, ingesting highly reduced intake: 180 Kcal/day coupled with active walking at least...
We apply innovative mathematical tools coming from optimal control theory to improve theoretical and experimental techniques in Magnetic Resonance Imaging (MRI). This approach allows us explore experimentally reach the physical limits of corresponding spin dynamics presence typical imperfections limitations. study this paper two important goals, namely optimization image contrast maximization signal noise per unit time. anticipate that proposed will find practical applications medical...
Object A novel method of estimating metabolite T1 relaxation times using MR spectroscopic imaging (MRSI) is proposed. As opposed to conventional single-voxel estimation methods, this investigates regional and gray matter (GM)/white (WM) differences in by taking advantage the spatial distribution information provided MRSI. Material methods The method, validated Monte Carlo studies, involves a voxel averaging preserve GM/WM distribution, non-linear least squares fit an its standard error...
Purpose This article proposes a rigorous optimal control framework for the design of preparation schemes that optimize MRI contrast based on relaxation time differences. Methods Compared to previous schemes, drastic reduction optimization parameter number is performed. The scheme defined as combination several block pulses whose flip angles, phase terms and inter‐pulse delays are optimized magnetization evolution. Results proposed approach reduces computation ‐robust around minute (whereas...
In this second part of a two-part paper, we intend to demonstrate the impact previously proposed advanced quality control pipeline. To understand its benefit and challenge methodology in real scenario, chose compare outcome when applying it analysis two patient populations with significant but highly different types fatigue: COVID-19 multiple sclerosis (MS). 31 P-MRS was performed on 3 T clinical MRI, 19 patients, 38 MS 40 matched healthy controls. Dynamic acquisitions using an MR-compatible...