A5101909372- Supramolecular Self-Assembly in Materials
- Mast cells and histamine
- Electrospun Nanofibers in Biomedical Applications
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Polymer Surface Interaction Studies
- Neurological Disease Mechanisms and Treatments
- Wound Healing and Treatments
- Chemical Synthesis and Analysis
- Plant Pathogens and Fungal Diseases
- Bone Tissue Engineering Materials
- Mycotoxins in Agriculture and Food
- Neurobiology and Insect Physiology Research
- Corneal Surgery and Treatments
- Asthma and respiratory diseases
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Biochemical effects in animals
- Antimicrobial Peptides and Activities
- Cellular transport and secretion
- Polydiacetylene-based materials and applications
- Ocular Surface and Contact Lens
- Advanced Fluorescence Microscopy Techniques
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
Wenzhou Medical University
2021-2025
Sichuan Agricultural University
2019-2024
North China University of Water Resources and Electric Power
2024
Lanzhou University
2024
Southwest Jiaotong University
2008-2023
University of Alberta
2016-2021
China Pharmaceutical University
2021
Air Force Medical University
2020
Xijing Hospital
2020
Chengdu University
2020
Hydrogel dressings not only have basic functions such as swelling, water retention, gas permeability, and good biocompatibility but also can be endowed with advanced antibacterial, antioxidant, adhesion, hemostasis, anti-inflammation, which make hydrogels great application potential in clinical trauma. However, the complexity of wound healing process makes development multifunctional a challenge. In this work, based on thiol–ene photoclickable PEG hydrogel, inclusion complex hydrophobic drug...
Biocompatible aggregation-induced emission (AIE) materials from natural resources are of great interest for a variety potential applications. Here, we report the unconventional AIE nature green tea polyphenol epigallocatechin gallate (EGCG), which is investigated by observing disappearance and reoccurrence fluorescence when EGCG dissolved recrystallized in aqueous solutions. The intermolecular through-space conjugation structural rigidification induced multiple H-bonds play critical roles...
Heavy rare earth elements (HREE) are strategic metals in China, primarily sourced from ion-adsorption type heavy deposits (iHREE). Granite constitutes an important parent rock for iHREE. Generally, (REE) undergo pre-concentration during the process of formation, which is crucial mineralization HREE. However, mechanisms migration and concentration HREE magmatic-hydrothermal (alteration) processes remain unclear. The typical iHREE Lincang, Yunnan Province, exhibits multiple episodes granite...
The local, intramyocardial injection of proteins into the infarcted heart is an attractive option to initiate cardiac regeneration after myocardial infarction (MI). Liraglutide, which was developed as a treatment for type 2 diabetes, has been implicated one most promising protein candidates in regeneration. A significant challenge therapeutic use this its short half-life vivo. In study, we evaluated effects and long-term retention liraglutide loaded poly(lactic-co-glycolic...
Abstract Real‐time imaging of cell‐surface‐associated proteolytic enzymes is critical to better understand their performances in both physiological and pathological processes. However, most current approaches are limited by complexity poor membrane‐anchoring properties. Herein, we have designed synthesized a unique small‐molecule fluorescent probe, which combines the principles passive exogenous membrane insertion Förster resonance energy transfer (FRET) image cell‐surface‐localized...
Self-assembling peptide based hydrogels have a wide range of applications in the field tissue repair and regeneration. Because its physicochemical properties, (RADA)4 has been studied as potential platform for 3D cell culture, drug delivery, engineering. Despite some small molecule protein release studies with this system, there is lack work investigating controlled hydrophobic compounds (i.e., anti-inflammatory, anticancer, antibacterial drugs, etc.) that are important many clinical...
Engineering biomaterials to manipulate the immune response elicit specific therapeutic outcomes is a burgeoning field of research. Mast cells play distinct and central role in innate response, are characterized by their rapid release myriad proinflammatory mediators stimulation. These protective actions such as wound healing, angiogenesis, host defense against pathogens animal venoms. Considering that mast widely distributed tissues interface with external environment, loaded large amounts...
Inflammation plays a critical role in the development of hypoxia-ischemia (HI) induced newborn brain damage. A localized, sustained delivery dexamethasone (Dex) through an intracerebral injection could reduce inflammatory response injured perinatal while avoiding unnecessary side effects. Herein, investigated using anionic sulfobutyl ether β-cyclodextrin (SBE-β-CD) to load Dex (RADA)4 nanofiber networks as means reducing HI injury is investigated. The ionic interaction between SBE-β-CD and...
Abstract Wound healing in diabetes is retarded by the dysfunctional local microenvironment. Although there are many studies using hydrogels as substitutes for natural extracellular matrices (ECMs), that can mimic both structure and functions of ECM remain a challenge. Self‐assembling peptide RADA16 nanofiber has distinct advantages to provide biomimetic matrix structure. However, it still lacks biological cues promote angiogenesis vital significance diabetic wound healing. With customized...
A simple method is developed to construct anticoagulant surfaces via passive adsorption of heparin onto the protonated plasma-polymerized allylamine (PPAam) films from phosphate-buffered saline (PBS). These PPAam are found have high affinity heparin. Importantly, heparin-functionalized (Hep-PPAam) show good retention after long-term immersion in PBS. The Hep-PPAam surface prolongs activated partial thromboplastin time for about 20 s as compared 316L stainless steel even though amount only...
The management of wounds remains a significant healthcare challenge, highlighting the need for effective wound healing strategies. To address this, it is crucial to explore molecular mechanisms underlying tissue repair as well potential therapeutic approaches. Trypsin, serine protease, has been clinically utilized decades; however, still lacks systemic investigation on its role and related mechanism. This study aimed investigate effects low-dose trypsin both in vitro vivo. While an...